Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Colipase

Gene

CLPS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.PROSITE-ProRule annotation
Enterostatin has a biological activity as a satiety signal.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDigestion, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-BTA-192456. Digestion of dietary lipid.
R-BTA-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:CLPS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17By similarityAdd BLAST17
PropeptideiPRO_000031494618 – 22Enterostatin, activation peptideSequence analysis5
ChainiPRO_000031494723 – 112ColipaseAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 45PROSITE-ProRule annotation
Disulfide bondi40 ↔ 56PROSITE-ProRule annotation
Disulfide bondi44 ↔ 78PROSITE-ProRule annotation
Disulfide bondi66 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA0JNQ7.
PRIDEiA0JNQ7.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.PROSITE-ProRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022391.

Structurei

3D structure databases

ProteinModelPortaliA0JNQ7.
SMRiA0JNQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
GeneTreeiENSGT00390000012644.
HOGENOMiHOG000059253.
HOVERGENiHBG005373.
InParanoidiA0JNQ7.
KOiK14460.
OMAiCSAKTLY.
OrthoDBiEOG091G0Z2E.
TreeFamiTF336178.

Family and domain databases

CDDicd00039. COLIPASE. 1 hit.
InterProiView protein in InterPro
IPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiView protein in Pfam
PF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
PRINTSiPR00128. COLIPASE.
SMARTiView protein in SMART
SM00023. COLIPASE. 1 hit.
PROSITEiView protein in PROSITE
PS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0JNQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVLILLLV ALAVAYAVPD PRGIIINLDE GELCLNSAQC TSKCCHREDG
60 70 80 90 100
LSLARCAPKA SENSECSAFT LYGIYYKCPC ERGLTCNVDK TIVGSITNTN
110
FGVCLDLGRA TE
Length:112
Mass (Da):12,051
Last modified:December 12, 2006 - v1
Checksum:i949B4F9BB9250BC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126854 mRNA. Translation: AAI26855.1.
BC142041 mRNA. Translation: AAI42042.1.
RefSeqiNP_001071435.1. NM_001077967.2.
UniGeneiBt.74388.

Genome annotation databases

EnsembliENSBTAT00000022391; ENSBTAP00000022391; ENSBTAG00000016833.
GeneIDi525923.
KEGGibta:525923.

Similar proteinsi

Entry informationi

Entry nameiCOL_BOVIN
AccessioniPrimary (citable) accession number: A0JNQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: March 15, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families