A0JNM6 (LYZL1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme-like protein 1
EC=3.2.1.17

Gene names

Name:

LYZL1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer Probable.
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 148	129	Lysozyme-like protein 1		PRO_0000287123
Sites
	Active site	54	1	By similarity
	Active site	71	1	By similarity
Amino acid modifications
	Glycosylation	58	1	N-linked (GlcNAc...) Potential
	Disulfide bond	25 ↔ 145		By similarity
	Disulfide bond	49 ↔ 133		By similarity
	Disulfide bond	83 ↔ 98		By similarity
	Disulfide bond	94 ↔ 112		By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0JNM6 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 00DF85E11026F6D3	FASTA	148	16,779
	10 20 30 40 50 60 MKAAGILALM GCLVTVVEPK VYTRCKLAKI FSRASLDNYR GFSLGNWICM AYYESHYNTT 70 80 90 100 110 120 AQTQLEDGST DYGIFQINSD TWCRSTKLQE KNRCHVACSA LMTDDLTDAI ICAKKIVKET 130 140 DGMNYWQGWK KNCEGRDLSE WKKGCEVS

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC126794 mRNA. Translation: AAI26795.1.
IPI	IPI00696700.
RefSeq	NP_001071378.1. NM_001077910.1.
UniGene	Bt.54250.
3D structure databases
ProteinModelPortal	A0JNM6.
SMR	A0JNM6. Positions 20-147.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000013640.
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000013640; ENSBTAP00000013640; ENSBTAG00000010330.
GeneID	512087.
KEGG	bta:512087.
Organism-specific databases
CTD	84569.
Phylogenomic databases
eggNOG	NOG72851.
GeneTree	ENSGT00550000074398.
HOGENOM	HOG000037357.
HOVERGEN	HBG052297.
InParanoid	A0JNM6.
KO	K01185.
OMA	QKNHCHV.
OrthoDB	EOG46WZ9C.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. IPR023346. Lysozyme-like_dom. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20870244.

Entry information

Entry name

LYZL1_BOVIN

Accession

Primary (citable) accession number: A0JNM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	December 12, 2006
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program