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Protein

Myosin light chain 1/3, skeletal muscle isoform

Gene

MYL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-BTA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 1/3, skeletal muscle isoform
Short name:
MLC1/MLC3
Short name:
MLC1F/MLC3F
Alternative name(s):
Myosin light chain alkali 1/2
Short name:
Myosin light chain A1/A2
Gene namesi
Name:MYL1Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 192191Myosin light chain 1/3, skeletal muscle isoformPRO_0000283742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N,N,N-trimethylalanineBy similarity
Modified residuei69 – 691PhosphothreonineBy similarity
Modified residuei71 – 711PhosphoserineBy similarity
Modified residuei85 – 851PhosphothreonineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiA0JNJ5.
PRIDEiA0JNJ5.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049636.

Structurei

3D structure databases

ProteinModelPortaliA0JNJ5.
SMRiA0JNJ5. Positions 45-191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 8336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini125 – 16036EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini160 – 19233EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiA0JNJ5.
KOiK05738.
OMAiTNAEINK.
OrthoDBiEOG7HQN9N.
TreeFamiTF351553.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0JNJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKDVKKP AAAAAPAPAP APAPAPAPAP PKEEKIDLSA IKIEFSKQQQ
60 70 80 90 100
DEFKEAFLLF DRTGECKITL SQVGDVLRAL GTNPTNAEVK KVLGNPSNEE
110 120 130 140 150
MNAKKIEFEQ FLPMLQAISN NKDQGTYEDF VEGLRVFDKE GNGTVMGAEL
160 170 180 190
RHVLATLGEK MKEEEVEALM AGQEDSNGCI NYEAFVKHIM SN
Length:192
Mass (Da):20,932
Last modified:December 12, 2006 - v1
Checksum:iEF12E3D0BC90BACC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101Q → E in AAA86910 (PubMed:7762638).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126716 mRNA. Translation: AAI26717.1.
U45430 mRNA. Translation: AAA86910.1.
RefSeqiNP_001073046.1. NM_001079578.1.
XP_005202773.1. XM_005202716.2.
UniGeneiBt.109731.

Genome annotation databases

EnsembliENSBTAT00000054271; ENSBTAP00000049636; ENSBTAG00000009707.
GeneIDi317657.
KEGGibta:317657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126716 mRNA. Translation: AAI26717.1.
U45430 mRNA. Translation: AAA86910.1.
RefSeqiNP_001073046.1. NM_001079578.1.
XP_005202773.1. XM_005202716.2.
UniGeneiBt.109731.

3D structure databases

ProteinModelPortaliA0JNJ5.
SMRiA0JNJ5. Positions 45-191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049636.

Proteomic databases

PaxDbiA0JNJ5.
PRIDEiA0JNJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000054271; ENSBTAP00000049636; ENSBTAG00000009707.
GeneIDi317657.
KEGGibta:317657.

Organism-specific databases

CTDi4632.

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiA0JNJ5.
KOiK05738.
OMAiTNAEINK.
OrthoDBiEOG7HQN9N.
TreeFamiTF351553.

Enzyme and pathway databases

ReactomeiR-BTA-390522. Striated Muscle Contraction.

Miscellaneous databases

NextBioi20807133.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: HerefordImported.
    Tissue: Fetal muscleImported.
  2. "Bovine fast-twitch myosin light chain 1: cloning and mRNA amount in muscle of cattle treated with clenbuterol."
    Smith S.B., Davis S.K., Wilson J.J., Stone R.T., Wu F.Y., Garcia D.K., Lunt D.K., Schiavetta A.M.
    Am. J. Physiol. 268:E858-E865(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-192.
    Tissue: Longissimus dorsi muscleImported.

Entry informationi

Entry nameiMYL1_BOVIN
AccessioniPrimary (citable) accession number: A0JNJ5
Secondary accession number(s): Q29436
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 12, 2006
Last modified: December 9, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.