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Protein

SH3 and cysteine-rich domain-containing protein

Gene

STAC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri108 – 160Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein
Alternative name(s):
Src homology 3 and cysteine-rich domain-containing protein
Gene namesi
Name:STAC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002744121 – 403SH3 and cysteine-rich domain-containing proteinAdd BLAST403

Proteomic databases

PaxDbiA0JNJ1
PRIDEiA0JNJ1

Interactioni

Subunit structurei

Interacts (via SH3 domains) with CACNA1S (By similarity). Interacts with CACNA1H. May interact with CACNA1C (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008854

Structurei

3D structure databases

ProteinModelPortaliA0JNJ1
SMRiA0JNJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 345SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini348 – 403SH3 2PROSITE-ProRule annotationAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi103 – 106Poly-Gly4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri108 – 160Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Repeat, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF5B Eukaryota
ENOG410XQKX LUCA
HOGENOMiHOG000230980
HOVERGENiHBG017859
InParanoidiA0JNJ1

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR002219 PE/DAG-bd
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035508 STAC1
PANTHERiPTHR15135:SF3 PTHR15135:SF3, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0JNJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPSGARED GVDGLPKETA SAEQPPSPAS TGSQESKLQK LKRSLSFKTK
60 70 80 90 100
SLRSKSADNF FQRTNSDVKL QADVLAGVSP GSSPLPAPGS LTCTPTRAGL
110 120 130 140 150
YPGGGGKAHA FQEHIFKKPT FCDVCNHMIV GTNAKHGLRC KACKMSIHHK
160 170 180 190 200
CMDGLAPQRC MGKLPKGFRR YYSSPLLIHE QFGCIKEVMP IACGNKVDPV
210 220 230 240 250
YETLRFGTSL AQRTKKSSSG SGSDSPHRTS TSDLVEVPEE ADGPGDGYDL
260 270 280 290 300
RKRSNSVFTY PENGTDDFRD QAKNINHQGP LSKDPLQMNT YVALYKFVPQ
310 320 330 340 350
ENEDLEMRPG DMITLLEDSN EDWWKGKIQD RIGFFPANFV QRVHQNEKIF
360 370 380 390 400
RCVRTFSGCK EQGQITLKEN QICVASEEEQ DGFIRVLSGK KRGLVPLDVL

ENI
Length:403
Mass (Da):44,487
Last modified:December 12, 2006 - v1
Checksum:iEA90A0E47DCBD9FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126707 mRNA Translation: AAI26708.1
RefSeqiNP_001071430.1, NM_001077962.2
UniGeneiBt.32379

Genome annotation databases

GeneIDi524215
KEGGibta:524215

Similar proteinsi

Entry informationi

Entry nameiSTAC_BOVIN
AccessioniPrimary (citable) accession number: A0JNJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 12, 2006
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health