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Protein

SH3 and cysteine-rich domain-containing protein

Gene

STAC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in a neuron-specific signal transduction.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri108 – 160Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein
Alternative name(s):
Src homology 3 and cysteine-rich domain-containing protein
Gene namesi
Name:STAC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002744121 – 403SH3 and cysteine-rich domain-containing proteinAdd BLAST403

Proteomic databases

PaxDbiA0JNJ1.
PRIDEiA0JNJ1.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008854.

Structurei

3D structure databases

ProteinModelPortaliA0JNJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 345SH3PROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi103 – 106Poly-Gly4

Sequence similaritiesi

Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri108 – 160Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF5B. Eukaryota.
ENOG410XQKX. LUCA.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiA0JNJ1.

Family and domain databases

CDDicd00029. C1. 1 hit.
InterProiIPR002219. PE/DAG-bd.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JNJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPSGARED GVDGLPKETA SAEQPPSPAS TGSQESKLQK LKRSLSFKTK
60 70 80 90 100
SLRSKSADNF FQRTNSDVKL QADVLAGVSP GSSPLPAPGS LTCTPTRAGL
110 120 130 140 150
YPGGGGKAHA FQEHIFKKPT FCDVCNHMIV GTNAKHGLRC KACKMSIHHK
160 170 180 190 200
CMDGLAPQRC MGKLPKGFRR YYSSPLLIHE QFGCIKEVMP IACGNKVDPV
210 220 230 240 250
YETLRFGTSL AQRTKKSSSG SGSDSPHRTS TSDLVEVPEE ADGPGDGYDL
260 270 280 290 300
RKRSNSVFTY PENGTDDFRD QAKNINHQGP LSKDPLQMNT YVALYKFVPQ
310 320 330 340 350
ENEDLEMRPG DMITLLEDSN EDWWKGKIQD RIGFFPANFV QRVHQNEKIF
360 370 380 390 400
RCVRTFSGCK EQGQITLKEN QICVASEEEQ DGFIRVLSGK KRGLVPLDVL

ENI
Length:403
Mass (Da):44,487
Last modified:December 12, 2006 - v1
Checksum:iEA90A0E47DCBD9FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126707 mRNA. Translation: AAI26708.1.
RefSeqiNP_001071430.1. NM_001077962.2.
UniGeneiBt.32379.

Genome annotation databases

GeneIDi524215.
KEGGibta:524215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126707 mRNA. Translation: AAI26708.1.
RefSeqiNP_001071430.1. NM_001077962.2.
UniGeneiBt.32379.

3D structure databases

ProteinModelPortaliA0JNJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008854.

Proteomic databases

PaxDbiA0JNJ1.
PRIDEiA0JNJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi524215.
KEGGibta:524215.

Organism-specific databases

CTDi6769.

Phylogenomic databases

eggNOGiENOG410IF5B. Eukaryota.
ENOG410XQKX. LUCA.
HOGENOMiHOG000230980.
HOVERGENiHBG017859.
InParanoidiA0JNJ1.

Family and domain databases

CDDicd00029. C1. 1 hit.
InterProiIPR002219. PE/DAG-bd.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00109. C1. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAC_BOVIN
AccessioniPrimary (citable) accession number: A0JNJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 12, 2006
Last modified: November 30, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.