Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LIM/homeobox protein Lhx9

Gene

LHX9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in gonadal development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi267 – 326HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx9
Short name:
LIM homeobox protein 9
Gene namesi
Name:LHX9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:30878 LHX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002788391 – 397LIM/homeobox protein Lhx9Add BLAST397

Proteomic databases

PaxDbiA0JNI8
PRIDEiA0JNI8

Expressioni

Gene expression databases

BgeeiENSBTAG00000013499
ExpressionAtlasiA0JNI8 baseline

Interactioni

Subunit structurei

Interacts with LDB1 and LDB2.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041150

Structurei

3D structure databases

ProteinModelPortaliA0JNI8
SMRiA0JNI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 130LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini131 – 193LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000034022
HOVERGENiHBG006262
InParanoidiA0JNI8
OMAiGCNENDT
OrthoDBiEOG091G13BH
TreeFamiTF315442

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0JNI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIVGCRAED SSCPFRPPAM LFHGISGGHI QGIMEEMERR SKSEARLAKG
60 70 80 90 100
AQLNGRDAGM PPLSPEKPAL CAGCGGKIAD RYYLLAVDKQ WHLRCLKCCE
110 120 130 140 150
CKLALESELT CFAKDGSIYC KEDYYRRFSV QRCARCHLGI SASEMVMRAR
160 170 180 190 200
DSVYHLSCFT CSTCNKTLTT GDHFGMKDSL VYCRAHFETL LQGEYPPQLS
210 220 230 240 250
YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV NYNSGCNENE
260 270 280 290 300
ADHLDRDQQP YPPSQKTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL
310 320 330 340 350
AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS
360 370 380 390
GALSPPGTAT TLTDLTNPSI TVVTAVTSNM DSHESASPSQ TTLTNLF
Length:397
Mass (Da):43,889
Last modified:March 3, 2009 - v2
Checksum:iC7BBF0DE784C6FBD
GO
Isoform 2 (identifier: A0JNI8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MEIVGCRAEDSSCPFRPP → MLNGTTLEA

Show »
Length:388
Mass (Da):42,844
Checksum:iBDE73FC8C9B69EF2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0364271 – 18MEIVG…PFRPP → MLNGTTLEA in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT026326 mRNA Translation: ABG81482.1
BC126704 mRNA Translation: AAI26705.1
RefSeqiXP_010811854.1, XM_010813552.2 [A0JNI8-1]
XP_015330757.1, XM_015475271.1 [A0JNI8-2]
UniGeneiBt.31799

Genome annotation databases

EnsembliENSBTAT00000043591; ENSBTAP00000041150; ENSBTAG00000013499 [A0JNI8-1]
ENSBTAT00000054943; ENSBTAP00000050628; ENSBTAG00000013499 [A0JNI8-2]
GeneIDi515012

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLHX9_BOVIN
AccessioniPrimary (citable) accession number: A0JNI8
Secondary accession number(s): Q0V893
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health