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A0JNI8

- LHX9_BOVIN

UniProt

A0JNI8 - LHX9_BOVIN

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Protein

LIM/homeobox protein Lhx9

Gene

LHX9

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in gonadal development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi267 – 32660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. transcription corepressor activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. female gonad development Source: Ensembl
  3. gonad morphogenesis Source: Ensembl
  4. male gonad development Source: Ensembl
  5. motor neuron axon guidance Source: UniProtKB
  6. negative regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx9
Short name:
LIM homeobox protein 9
Gene namesi
Name:LHX9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 16

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397LIM/homeobox protein Lhx9PRO_0000278839Add
BLAST

Interactioni

Subunit structurei

Interacts with LDB1 and LDB2.By similarity

Structurei

3D structure databases

ProteinModelPortaliA0JNI8.
SMRiA0JNI8. Positions 268-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 13062LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini131 – 19363LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG240987.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000034022.
HOVERGENiHBG006262.
InParanoidiA0JNI8.
KOiK09373.
OMAiSHDSGSP.
OrthoDBiEOG7966GV.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A0JNI8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIVGCRAED SSCPFRPPAM LFHGISGGHI QGIMEEMERR SKSEARLAKG
60 70 80 90 100
AQLNGRDAGM PPLSPEKPAL CAGCGGKIAD RYYLLAVDKQ WHLRCLKCCE
110 120 130 140 150
CKLALESELT CFAKDGSIYC KEDYYRRFSV QRCARCHLGI SASEMVMRAR
160 170 180 190 200
DSVYHLSCFT CSTCNKTLTT GDHFGMKDSL VYCRAHFETL LQGEYPPQLS
210 220 230 240 250
YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV NYNSGCNENE
260 270 280 290 300
ADHLDRDQQP YPPSQKTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL
310 320 330 340 350
AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS
360 370 380 390
GALSPPGTAT TLTDLTNPSI TVVTAVTSNM DSHESASPSQ TTLTNLF
Length:397
Mass (Da):43,889
Last modified:March 3, 2009 - v2
Checksum:iC7BBF0DE784C6FBD
GO
Isoform 2 (identifier: A0JNI8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MEIVGCRAEDSSCPFRPP → MLNGTTLEA

Show »
Length:388
Mass (Da):42,844
Checksum:iBDE73FC8C9B69EF2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818MEIVG…PFRPP → MLNGTTLEA in isoform 2. 1 PublicationVSP_036427Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT026326 mRNA. Translation: ABG81482.1.
BC126704 mRNA. Translation: AAI26705.1.
RefSeqiXP_005217407.1. XM_005217350.1. [A0JNI8-2]
UniGeneiBt.31799.

Genome annotation databases

EnsembliENSBTAT00000043591; ENSBTAP00000041150; ENSBTAG00000013499. [A0JNI8-1]
ENSBTAT00000054943; ENSBTAP00000050628; ENSBTAG00000013499. [A0JNI8-2]
GeneIDi515012.
KEGGibta:515012.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT026326 mRNA. Translation: ABG81482.1 .
BC126704 mRNA. Translation: AAI26705.1 .
RefSeqi XP_005217407.1. XM_005217350.1. [A0JNI8-2 ]
UniGenei Bt.31799.

3D structure databases

ProteinModelPortali A0JNI8.
SMRi A0JNI8. Positions 268-334.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000043591 ; ENSBTAP00000041150 ; ENSBTAG00000013499 . [A0JNI8-1 ]
ENSBTAT00000054943 ; ENSBTAP00000050628 ; ENSBTAG00000013499 . [A0JNI8-2 ]
GeneIDi 515012.
KEGGi bta:515012.

Organism-specific databases

CTDi 56956.

Phylogenomic databases

eggNOGi NOG240987.
GeneTreei ENSGT00760000118921.
HOGENOMi HOG000034022.
HOVERGENi HBG006262.
InParanoidi A0JNI8.
KOi K09373.
OMAi SHDSGSP.
OrthoDBi EOG7966GV.
TreeFami TF315442.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiLHX9_BOVIN
AccessioniPrimary (citable) accession number: A0JNI8
Secondary accession number(s): Q0V893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3