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Protein

LIM/homeobox protein Lhx9

Gene

LHX9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in gonadal development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi267 – 32660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx9
Short name:
LIM homeobox protein 9
Gene namesi
Name:LHX9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 16

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397LIM/homeobox protein Lhx9PRO_0000278839Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiA0JNI8. baseline.

Interactioni

Subunit structurei

Interacts with LDB1 and LDB2.By similarity

Structurei

3D structure databases

ProteinModelPortaliA0JNI8.
SMRiA0JNI8. Positions 268-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 13062LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini131 – 19363LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG240987.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000034022.
HOVERGENiHBG006262.
InParanoidiA0JNI8.
KOiK09373.
OMAiAVERAWH.
OrthoDBiEOG7966GV.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0JNI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIVGCRAED SSCPFRPPAM LFHGISGGHI QGIMEEMERR SKSEARLAKG
60 70 80 90 100
AQLNGRDAGM PPLSPEKPAL CAGCGGKIAD RYYLLAVDKQ WHLRCLKCCE
110 120 130 140 150
CKLALESELT CFAKDGSIYC KEDYYRRFSV QRCARCHLGI SASEMVMRAR
160 170 180 190 200
DSVYHLSCFT CSTCNKTLTT GDHFGMKDSL VYCRAHFETL LQGEYPPQLS
210 220 230 240 250
YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV NYNSGCNENE
260 270 280 290 300
ADHLDRDQQP YPPSQKTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL
310 320 330 340 350
AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS
360 370 380 390
GALSPPGTAT TLTDLTNPSI TVVTAVTSNM DSHESASPSQ TTLTNLF
Length:397
Mass (Da):43,889
Last modified:March 3, 2009 - v2
Checksum:iC7BBF0DE784C6FBD
GO
Isoform 2 (identifier: A0JNI8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MEIVGCRAEDSSCPFRPP → MLNGTTLEA

Show »
Length:388
Mass (Da):42,844
Checksum:iBDE73FC8C9B69EF2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818MEIVG…PFRPP → MLNGTTLEA in isoform 2. 1 PublicationVSP_036427Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT026326 mRNA. Translation: ABG81482.1.
BC126704 mRNA. Translation: AAI26705.1.
RefSeqiXP_005217407.1. XM_005217350.2. [A0JNI8-2]
XP_010811854.1. XM_010813552.1. [A0JNI8-1]
UniGeneiBt.31799.

Genome annotation databases

EnsembliENSBTAT00000043591; ENSBTAP00000041150; ENSBTAG00000013499. [A0JNI8-1]
ENSBTAT00000054943; ENSBTAP00000050628; ENSBTAG00000013499. [A0JNI8-2]
GeneIDi515012.
KEGGibta:515012.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT026326 mRNA. Translation: ABG81482.1.
BC126704 mRNA. Translation: AAI26705.1.
RefSeqiXP_005217407.1. XM_005217350.2. [A0JNI8-2]
XP_010811854.1. XM_010813552.1. [A0JNI8-1]
UniGeneiBt.31799.

3D structure databases

ProteinModelPortaliA0JNI8.
SMRiA0JNI8. Positions 268-334.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000043591; ENSBTAP00000041150; ENSBTAG00000013499. [A0JNI8-1]
ENSBTAT00000054943; ENSBTAP00000050628; ENSBTAG00000013499. [A0JNI8-2]
GeneIDi515012.
KEGGibta:515012.

Organism-specific databases

CTDi56956.

Phylogenomic databases

eggNOGiNOG240987.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000034022.
HOVERGENiHBG006262.
InParanoidiA0JNI8.
KOiK09373.
OMAiAVERAWH.
OrthoDBiEOG7966GV.
TreeFamiTF315442.

Gene expression databases

ExpressionAtlasiA0JNI8. baseline.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiLHX9_BOVIN
AccessioniPrimary (citable) accession number: A0JNI8
Secondary accession number(s): Q0V893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 3, 2009
Last modified: April 1, 2015
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.