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A0JNI8 (LHX9_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
LIM/homeobox protein Lhx9
Short name=LIM homeobox protein 9
Gene names
Name:LHX9
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in gonadal development By similarity.

Subunit structure

Interacts with LDB1 and LDB2 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Contains 2 LIM zinc-binding domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A0JNI8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A0JNI8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MEIVGCRAEDSSCPFRPP → MLNGTTLEA

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397LIM/homeobox protein Lhx9
PRO_0000278839

Regions

Domain69 – 13062LIM zinc-binding 1
Domain131 – 19363LIM zinc-binding 2
DNA binding267 – 32660Homeobox

Natural variations

Alternative sequence1 – 1818MEIVG…PFRPP → MLNGTTLEA in isoform 2.
VSP_036427

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: C7BBF0DE784C6FBD

FASTA39743,889
        10         20         30         40         50         60 
MEIVGCRAED SSCPFRPPAM LFHGISGGHI QGIMEEMERR SKSEARLAKG AQLNGRDAGM 

        70         80         90        100        110        120 
PPLSPEKPAL CAGCGGKIAD RYYLLAVDKQ WHLRCLKCCE CKLALESELT CFAKDGSIYC 

       130        140        150        160        170        180 
KEDYYRRFSV QRCARCHLGI SASEMVMRAR DSVYHLSCFT CSTCNKTLTT GDHFGMKDSL 

       190        200        210        220        230        240 
VYCRAHFETL LQGEYPPQLS YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV 

       250        260        270        280        290        300 
NYNSGCNENE ADHLDRDQQP YPPSQKTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL 

       310        320        330        340        350        360 
AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS GALSPPGTAT 

       370        380        390 
TLTDLTNPSI TVVTAVTSNM DSHESASPSQ TTLTNLF

« Hide

Isoform 2 [UniParc].

Checksum: BDE73FC8C9B69EF2
Show »

FASTA38842,844

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT026326 mRNA. Translation: ABG81482.1.
BC126704 mRNA. Translation: AAI26705.1.
IPIIPI00692674.
IPI00839239.
UniGeneBt.31799.

3D structure databases

ProteinModelPortalA0JNI8.
SMRA0JNI8. Positions 268-334.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000043591; ENSBTAP00000041150; ENSBTAG00000013499.
ENSBTAT00000054943; ENSBTAP00000050628; ENSBTAG00000013499.

Phylogenomic databases

eggNOGNOG240987.
GeneTreeENSGT00680000099670.
HOGENOMHOG000034022.
HOVERGENHBG006262.
InParanoidQ0V893.
OMAAAMLFHG.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLHX9_BOVIN
AccessionPrimary (citable) accession number: A0JNI8
Secondary accession number(s): Q0V893
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 3, 2009
Last modified: April 3, 2013
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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