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A0JNI8

- LHX9_BOVIN

UniProt

A0JNI8 - LHX9_BOVIN

Protein

LIM/homeobox protein Lhx9

Gene

LHX9

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Involved in gonadal development.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi267 – 32660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. transcription corepressor activity Source: UniProtKB
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell proliferation Source: Ensembl
    2. female gonad development Source: Ensembl
    3. gonad morphogenesis Source: Ensembl
    4. male gonad development Source: Ensembl
    5. motor neuron axon guidance Source: UniProtKB
    6. negative regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM/homeobox protein Lhx9
    Short name:
    LIM homeobox protein 9
    Gene namesi
    Name:LHX9
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 16

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397LIM/homeobox protein Lhx9PRO_0000278839Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with LDB1 and LDB2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA0JNI8.
    SMRiA0JNI8. Positions 268-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini69 – 13062LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini131 – 19363LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG240987.
    GeneTreeiENSGT00750000117279.
    HOGENOMiHOG000034022.
    HOVERGENiHBG006262.
    InParanoidiQ0V893.
    KOiK09373.
    OMAiSHDSGSP.
    OrthoDBiEOG7966GV.
    TreeFamiTF315442.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A0JNI8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEIVGCRAED SSCPFRPPAM LFHGISGGHI QGIMEEMERR SKSEARLAKG    50
    AQLNGRDAGM PPLSPEKPAL CAGCGGKIAD RYYLLAVDKQ WHLRCLKCCE 100
    CKLALESELT CFAKDGSIYC KEDYYRRFSV QRCARCHLGI SASEMVMRAR 150
    DSVYHLSCFT CSTCNKTLTT GDHFGMKDSL VYCRAHFETL LQGEYPPQLS 200
    YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV NYNSGCNENE 250
    ADHLDRDQQP YPPSQKTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL 300
    AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS 350
    GALSPPGTAT TLTDLTNPSI TVVTAVTSNM DSHESASPSQ TTLTNLF 397
    Length:397
    Mass (Da):43,889
    Last modified:March 3, 2009 - v2
    Checksum:iC7BBF0DE784C6FBD
    GO
    Isoform 2 (identifier: A0JNI8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: MEIVGCRAEDSSCPFRPP → MLNGTTLEA

    Show »
    Length:388
    Mass (Da):42,844
    Checksum:iBDE73FC8C9B69EF2
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1818MEIVG…PFRPP → MLNGTTLEA in isoform 2. 1 PublicationVSP_036427Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT026326 mRNA. Translation: ABG81482.1.
    BC126704 mRNA. Translation: AAI26705.1.
    RefSeqiXP_005217407.1. XM_005217350.1. [A0JNI8-2]
    UniGeneiBt.31799.

    Genome annotation databases

    EnsembliENSBTAT00000043591; ENSBTAP00000041150; ENSBTAG00000013499. [A0JNI8-1]
    ENSBTAT00000054943; ENSBTAP00000050628; ENSBTAG00000013499. [A0JNI8-2]
    GeneIDi515012.
    KEGGibta:515012.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT026326 mRNA. Translation: ABG81482.1 .
    BC126704 mRNA. Translation: AAI26705.1 .
    RefSeqi XP_005217407.1. XM_005217350.1. [A0JNI8-2 ]
    UniGenei Bt.31799.

    3D structure databases

    ProteinModelPortali A0JNI8.
    SMRi A0JNI8. Positions 268-334.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000043591 ; ENSBTAP00000041150 ; ENSBTAG00000013499 . [A0JNI8-1 ]
    ENSBTAT00000054943 ; ENSBTAP00000050628 ; ENSBTAG00000013499 . [A0JNI8-2 ]
    GeneIDi 515012.
    KEGGi bta:515012.

    Organism-specific databases

    CTDi 56956.

    Phylogenomic databases

    eggNOGi NOG240987.
    GeneTreei ENSGT00750000117279.
    HOGENOMi HOG000034022.
    HOVERGENi HBG006262.
    InParanoidi Q0V893.
    KOi K09373.
    OMAi SHDSGSP.
    OrthoDBi EOG7966GV.
    TreeFami TF315442.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiLHX9_BOVIN
    AccessioniPrimary (citable) accession number: A0JNI8
    Secondary accession number(s): Q0V893
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3