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Protein

Serine racemase

Gene

SRR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity).By similarity

Catalytic activityi

L-serine = D-serine.
L-serine = pyruvate + NH3.
D-serine = pyruvate + NH3.

Cofactori

Enzyme regulationi

Allosterically activated by magnesium, and possibly also other divalent metal cations. Allosterically activated by ATP, ADP or GTP (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51ATPBy similarity1
Active sitei56Proton acceptorBy similarity1
Active sitei84Proton acceptorBy similarity1
Binding sitei121ATPBy similarity1
Binding sitei135SubstrateBy similarity1
Metal bindingi210MagnesiumBy similarity1
Metal bindingi214Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi216MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Isomerase, Lyase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Serine racemase (EC:4.3.1.17, EC:4.3.1.18, EC:5.1.1.18)
Alternative name(s):
D-serine ammonia-lyase
D-serine dehydratase
L-serine ammonia-lyase
L-serine dehydratase
Gene namesi
Name:SRR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:35292. SRR.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002861721 – 334Serine racemaseAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei113S-nitrosocysteineBy similarity1

Post-translational modificationi

S-nitrosylated, leading to decrease the enzyme activity.By similarity

Keywords - PTMi

S-nitrosylation

Proteomic databases

PaxDbiA0JNI4.
PRIDEiA0JNI4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004223.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005532.

Structurei

3D structure databases

ProteinModelPortaliA0JNI4.
SMRiA0JNI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni238 – 239Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1250. Eukaryota.
COG1171. LUCA.
GeneTreeiENSGT00550000075026.
HOGENOMiHOG000046974.
HOVERGENiHBG023167.
InParanoidiA0JNI4.
KOiK12235.
OMAiLIHPFDH.
OrthoDBiEOG091G0FSJ.
TreeFamiTF313346.

Family and domain databases

InterProiView protein in InterPro
IPR001926. PLP-dep.
IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR036052. Trypto_synt_PLP_dependent.
PfamiView protein in Pfam
PF00291. PALP. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
PROSITEiView protein in PROSITE
PS00165. DEHYDRATASE_SER_THR. 1 hit.

Sequencei

Sequence statusi: Complete.

A0JNI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDQYCISFA DVEKAHINIR DFIHLTPVLT SSILNQITGR NLFFKCELFQ
60 70 80 90 100
KTGSFKIRGA LNAIRGLISA HPEEKPRAVV AHSSGNHGQA LSFAARLEGI
110 120 130 140 150
PAYVIVPETA PNCKKLAIQA YGASIVYSEQ SEESRENITK RIAEETEGIM
160 170 180 190 200
VHPNQEPAVI AGQGTIAMEV LNQVPLVDAL VVPVGGGGML AGIAVTVKAL
210 220 230 240 250
RPSVKVYAAE PLNADDCYQS KLKGELTPNP YPPETIADGI KSSIGLNTWP
260 270 280 290 300
IIRDLVDDVF TVTEDEIKYA TQLVWERMKL LIEPTAGVGV AVVLSQHFRT
310 320 330
VPAEVKNICI VLSGGNVDLT SLTWVKKQDE KAAP
Length:334
Mass (Da):36,181
Last modified:December 12, 2006 - v1
Checksum:i63277FE33D8FA45F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126700 mRNA. Translation: AAI26701.1.
RefSeqiNP_001071433.1. NM_001077965.2.
XP_010814138.1. XM_010815836.2.
XP_010814140.1. XM_010815838.2.
UniGeneiBt.102336.

Genome annotation databases

EnsembliENSBTAT00000005532; ENSBTAP00000005532; ENSBTAG00000004223.
GeneIDi525340.
KEGGibta:525340.

Similar proteinsi

Entry informationi

Entry nameiSRR_BOVIN
AccessioniPrimary (citable) accession number: A0JNI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome