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A0JND9

- ENTP8_BOVIN

UniProt

A0JND9 - ENTP8_BOVIN

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Protein
Ectonucleoside triphosphate diphosphohydrolase 8
Gene
ENTPD8
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP By similarity.

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactori

Ca2+ or Mg2+. Has lower efficiency with Mg2+ By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681Proton acceptor By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydrolase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ectonucleoside triphosphate diphosphohydrolase 8 (EC:3.6.1.5)
Short name:
E-NTPDase 8
Short name:
NTPDase 8
Short name:
NTPDase8
Gene namesi
Name:ENTPD8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Cytoplasmic Reviewed prediction
Transmembranei9 – 2921Helical; Reviewed prediction
Add
BLAST
Topological domaini30 – 466437Extracellular Reviewed prediction
Add
BLAST
Transmembranei467 – 48721Helical; Reviewed prediction
Add
BLAST
Topological domaini488 – 4958Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Ectonucleoside triphosphate diphosphohydrolase 8
PRO_0000306881Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 102 By similarity
Disulfide bondi246 ↔ 292 By similarity
Glycosylationi303 – 3031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi324 – 3241N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi328 ↔ 334 By similarity
Disulfide bondi380 ↔ 403 By similarity

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA0JND9.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016080.

Structurei

3D structure databases

ProteinModelPortaliA0JND9.

Family & Domainsi

Domaini

The transmembranous domains are involved in regulation of enzyme activity By similarity.

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5371.
HOGENOMiHOG000059572.
HOVERGENiHBG018982.
InParanoidiA0JND9.
KOiK01510.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 1 hit.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JND9-1 [UniParc]FASTAAdd to Basket

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MGLTWKQRVF TALLGAAAVS GLTALLLVLV GTMNVLLPPD TKFGIVFDAG    50
SSHTSLFVYQ WPANKENDTG IVSQALACQA EGPGISSYAS NPARVGESLQ 100
GCLEEALALI PKAKHHETPM FLGATAGMRL LSRKNRSQAE DVFAAVSRAL 150
GQSPVDFRGA ELLTGQDEGA FGWITINYIL GLLVKYSFSG EWIRPLEETL 200
VGALDMGGAS TQITFVPGGP ILDKTAQATF RLYGADHTVY THSYLCFGRD 250
QALSRVLAEL VQASTGLLIR HPCYHSGYRG TLALASLYES PCAPAAPPDL 300
SQNLTVEGTG NPGACVEALR KLFNFSSCDG REDCAFAGVY QPPVQGQFYA 350
FSNFYYTFNF LNLTSKPSLS GANATIWEFC LRPWKLVEAS APPGQDRWLR 400
DYCASGLYIL TLLVEGYGFS EETWGGIEFR QQAGGADIGW TLGYMLNLTN 450
LIPAEAPAQG WAQSFGVWAA GVVFVVLTLA ATLGAVAVQV FWLQD 495
Length:495
Mass (Da):53,240
Last modified:December 12, 2006 - v1
Checksum:i99082624BE7045F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126637 mRNA. Translation: AAI26638.1.
RefSeqiNP_001071395.1. NM_001077927.2.
UniGeneiBt.42111.

Genome annotation databases

GeneIDi515532.
KEGGibta:515532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126637 mRNA. Translation: AAI26638.1 .
RefSeqi NP_001071395.1. NM_001077927.2.
UniGenei Bt.42111.

3D structure databases

ProteinModelPortali A0JND9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000016080.

Proteomic databases

PRIDEi A0JND9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 515532.
KEGGi bta:515532.

Organism-specific databases

CTDi 377841.

Phylogenomic databases

eggNOGi COG5371.
HOGENOMi HOG000059572.
HOVERGENi HBG018982.
InParanoidi A0JND9.
KOi K01510.

Miscellaneous databases

NextBioi 20871868.

Family and domain databases

InterProi IPR000407. GDA1_CD39_NTPase.
[Graphical view ]
PANTHERi PTHR11782. PTHR11782. 1 hit.
Pfami PF01150. GDA1_CD39. 1 hit.
[Graphical view ]
PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiENTP8_BOVIN
AccessioniPrimary (citable) accession number: A0JND9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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