Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A0JND9

- ENTP8_BOVIN

UniProt

A0JND9 - ENTP8_BOVIN

Protein

Ectonucleoside triphosphate diphosphohydrolase 8

Gene

ENTPD8

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP By similarity.By similarity

    Catalytic activityi

    A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

    Cofactori

    Ca2+ or Mg2+. Has lower efficiency with Mg2+ By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei168 – 1681Proton acceptorBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydrolase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 8 (EC:3.6.1.5)
    Short name:
    E-NTPDase 8
    Short name:
    NTPDase 8
    Short name:
    NTPDase8
    Gene namesi
    Name:ENTPD8
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495Ectonucleoside triphosphate diphosphohydrolase 8PRO_0000306881Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi78 ↔ 102By similarity
    Disulfide bondi246 ↔ 292By similarity
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi328 ↔ 334By similarity
    Disulfide bondi380 ↔ 403By similarity

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiA0JND9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000016080.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JND9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini30 – 466437ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini488 – 4958CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei467 – 48721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The transmembranous domains are involved in regulation of enzyme activity.By similarity

    Sequence similaritiesi

    Belongs to the GDA1/CD39 NTPase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5371.
    HOGENOMiHOG000059572.
    HOVERGENiHBG018982.
    InParanoidiA0JND9.
    KOiK01510.

    Family and domain databases

    InterProiIPR000407. GDA1_CD39_NTPase.
    [Graphical view]
    PANTHERiPTHR11782. PTHR11782. 1 hit.
    PfamiPF01150. GDA1_CD39. 1 hit.
    [Graphical view]
    PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JND9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLTWKQRVF TALLGAAAVS GLTALLLVLV GTMNVLLPPD TKFGIVFDAG    50
    SSHTSLFVYQ WPANKENDTG IVSQALACQA EGPGISSYAS NPARVGESLQ 100
    GCLEEALALI PKAKHHETPM FLGATAGMRL LSRKNRSQAE DVFAAVSRAL 150
    GQSPVDFRGA ELLTGQDEGA FGWITINYIL GLLVKYSFSG EWIRPLEETL 200
    VGALDMGGAS TQITFVPGGP ILDKTAQATF RLYGADHTVY THSYLCFGRD 250
    QALSRVLAEL VQASTGLLIR HPCYHSGYRG TLALASLYES PCAPAAPPDL 300
    SQNLTVEGTG NPGACVEALR KLFNFSSCDG REDCAFAGVY QPPVQGQFYA 350
    FSNFYYTFNF LNLTSKPSLS GANATIWEFC LRPWKLVEAS APPGQDRWLR 400
    DYCASGLYIL TLLVEGYGFS EETWGGIEFR QQAGGADIGW TLGYMLNLTN 450
    LIPAEAPAQG WAQSFGVWAA GVVFVVLTLA ATLGAVAVQV FWLQD 495
    Length:495
    Mass (Da):53,240
    Last modified:December 12, 2006 - v1
    Checksum:i99082624BE7045F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126637 mRNA. Translation: AAI26638.1.
    RefSeqiNP_001071395.1. NM_001077927.2.
    UniGeneiBt.42111.

    Genome annotation databases

    GeneIDi515532.
    KEGGibta:515532.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126637 mRNA. Translation: AAI26638.1 .
    RefSeqi NP_001071395.1. NM_001077927.2.
    UniGenei Bt.42111.

    3D structure databases

    ProteinModelPortali A0JND9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000016080.

    Proteomic databases

    PRIDEi A0JND9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 515532.
    KEGGi bta:515532.

    Organism-specific databases

    CTDi 377841.

    Phylogenomic databases

    eggNOGi COG5371.
    HOGENOMi HOG000059572.
    HOVERGENi HBG018982.
    InParanoidi A0JND9.
    KOi K01510.

    Miscellaneous databases

    NextBioi 20871868.

    Family and domain databases

    InterProi IPR000407. GDA1_CD39_NTPase.
    [Graphical view ]
    PANTHERi PTHR11782. PTHR11782. 1 hit.
    Pfami PF01150. GDA1_CD39. 1 hit.
    [Graphical view ]
    PROSITEi PS01238. GDA1_CD39_NTPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiENTP8_BOVIN
    AccessioniPrimary (citable) accession number: A0JND9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3