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A0JND9 (ENTP8_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ectonucleoside triphosphate diphosphohydrolase 8

Short name=E-NTPDase 8
Short name=NTPDase 8
Short name=NTPDase8
EC=3.6.1.5
Gene names
Name:ENTPD8
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP By similarity.

Catalytic activity

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactor

Ca2+ or Mg2+. Has lower efficiency with Mg2+ By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Domain

The transmembranous domains are involved in regulation of enzyme activity By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the GDA1/CD39 NTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Ectonucleoside triphosphate diphosphohydrolase 8
PRO_0000306881

Regions

Topological domain1 – 88Cytoplasmic Potential
Transmembrane9 – 2921Helical; Potential
Topological domain30 – 466437Extracellular Potential
Transmembrane467 – 48721Helical; Potential
Topological domain488 – 4958Cytoplasmic Potential

Sites

Active site1681Proton acceptor By similarity

Amino acid modifications

Glycosylation3031N-linked (GlcNAc...) Potential
Glycosylation3241N-linked (GlcNAc...) Potential
Disulfide bond78 ↔ 102 By similarity
Disulfide bond246 ↔ 292 By similarity
Disulfide bond328 ↔ 334 By similarity
Disulfide bond380 ↔ 403 By similarity

Sequences

Sequence LengthMass (Da)Tools
A0JND9 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 99082624BE7045F7

FASTA49553,240
        10         20         30         40         50         60 
MGLTWKQRVF TALLGAAAVS GLTALLLVLV GTMNVLLPPD TKFGIVFDAG SSHTSLFVYQ 

        70         80         90        100        110        120 
WPANKENDTG IVSQALACQA EGPGISSYAS NPARVGESLQ GCLEEALALI PKAKHHETPM 

       130        140        150        160        170        180 
FLGATAGMRL LSRKNRSQAE DVFAAVSRAL GQSPVDFRGA ELLTGQDEGA FGWITINYIL 

       190        200        210        220        230        240 
GLLVKYSFSG EWIRPLEETL VGALDMGGAS TQITFVPGGP ILDKTAQATF RLYGADHTVY 

       250        260        270        280        290        300 
THSYLCFGRD QALSRVLAEL VQASTGLLIR HPCYHSGYRG TLALASLYES PCAPAAPPDL 

       310        320        330        340        350        360 
SQNLTVEGTG NPGACVEALR KLFNFSSCDG REDCAFAGVY QPPVQGQFYA FSNFYYTFNF 

       370        380        390        400        410        420 
LNLTSKPSLS GANATIWEFC LRPWKLVEAS APPGQDRWLR DYCASGLYIL TLLVEGYGFS 

       430        440        450        460        470        480 
EETWGGIEFR QQAGGADIGW TLGYMLNLTN LIPAEAPAQG WAQSFGVWAA GVVFVVLTLA 

       490 
ATLGAVAVQV FWLQD 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC126637 mRNA. Translation: AAI26638.1.
RefSeqNP_001071395.1. NM_001077927.2.
UniGeneBt.42111.

3D structure databases

ProteinModelPortalA0JND9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000016080.

Proteomic databases

PRIDEA0JND9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID515532.
KEGGbta:515532.

Organism-specific databases

CTD377841.

Phylogenomic databases

eggNOGCOG5371.
HOGENOMHOG000059572.
HOVERGENHBG018982.
InParanoidA0JND9.
KOK01510.

Family and domain databases

InterProIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERPTHR11782. PTHR11782. 1 hit.
PfamPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20871868.

Entry information

Entry nameENTP8_BOVIN
AccessionPrimary (citable) accession number: A0JND9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families