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A0JND3

- EOGT_BOVIN

UniProt

A0JND3 - EOGT_BOVIN

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Protein
EGF domain-specific O-linked N-acetylglucosamine transferase
Gene
EOGT, AER61
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains By similarity.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine.
UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine.

GO - Molecular functioni

  1. protein N-acetylglucosaminyltransferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. protein O-linked glycosylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT61. Glycosyltransferase Family 61.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF domain-specific O-linked N-acetylglucosamine transferase (EC:2.4.1.255)
Alternative name(s):
Extracellular O-linked N-acetylglucosamine transferase
Gene namesi
Name:EOGT
Synonyms:AER61
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 22

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 527510EGF domain-specific O-linked N-acetylglucosamine transferase
PRO_0000301969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi354 – 3541N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA0JND3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030725.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi295 – 2973Required for optimal activity By similarity
Motifi524 – 5274Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG320328.
GeneTreeiENSGT00750000117715.
HOGENOMiHOG000033829.
HOVERGENiHBG056678.
InParanoidiA0JND3.
KOiK18134.
OMAiDSKRVCF.
OrthoDBiEOG7D2FDQ.
TreeFamiTF313716.

Family and domain databases

InterProiIPR007657. Glycosyltransferase_AER61.
[Graphical view]
PfamiPF04577. DUF563. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0JND3-1 [UniParc]FASTAAdd to Basket

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MFMLLVFGAL LPEVPLSGQD KAPPQADGIS ATPLFNYASL RLPEEHIPFF    50
LHNNRHIATV CRKDSHCPYK KYLENLKYCW GYEKSCRPEF RFGYPVCTYV 100
DMGWTDTLES AQEIFWKQAD FGYAAERLEE LHVLCQPKEK NDSSLVCSRY 150
LQYCRATNIY LDLRNIKRNH DRFKEDFVQS GEIGGYCKLD IRSLMSQGQR 200
KSPLQSWFAE LQSYTELNFR PVEDAQCDIV IEKPTYFMKL DAGVNMYHHF 250
CDFINLYITQ HVNNSFSTDV YVVMWDTSSY GYGDLFSDTW KAFTDYDVIH 300
LKTYDAKRVC FKEAIFSLLP RMRYGLFYNT PLISGCQNTG LFRAFSQHVL 350
HRLNITQEGP KGGKIRVTIL ARSTEYRKIL NQNELVNALK TVSTFEVQIV 400
DYKYKELGFL DQLRITHNTD IFIGMHGAGL THLLFLPDWA AVFELYNCGD 450
ERCYLDLARL RGVHYITWRR QNKVFPQDKG HHPTLGEHPK FTNYSFDVEE 500
FMYLVLQAAD YVLQHPKWPF KKKHDEL 527
Length:527
Mass (Da):61,749
Last modified:December 12, 2006 - v1
Checksum:i1BDB2867FD8D13A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126625 mRNA. Translation: AAI26626.1.
RefSeqiNP_001071350.1. NM_001077882.1.
XP_005222695.1. XM_005222638.1.
XP_005222696.1. XM_005222639.1.
XP_005222697.1. XM_005222640.1.
XP_005222698.1. XM_005222641.1.
UniGeneiBt.21068.

Genome annotation databases

EnsembliENSBTAT00000030754; ENSBTAP00000030725; ENSBTAG00000022681.
GeneIDi508782.
KEGGibta:508782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126625 mRNA. Translation: AAI26626.1 .
RefSeqi NP_001071350.1. NM_001077882.1.
XP_005222695.1. XM_005222638.1.
XP_005222696.1. XM_005222639.1.
XP_005222697.1. XM_005222640.1.
XP_005222698.1. XM_005222641.1.
UniGenei Bt.21068.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000030725.

Protein family/group databases

CAZyi GT61. Glycosyltransferase Family 61.

Proteomic databases

PRIDEi A0JND3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000030754 ; ENSBTAP00000030725 ; ENSBTAG00000022681 .
GeneIDi 508782.
KEGGi bta:508782.

Organism-specific databases

CTDi 285203.

Phylogenomic databases

eggNOGi NOG320328.
GeneTreei ENSGT00750000117715.
HOGENOMi HOG000033829.
HOVERGENi HBG056678.
InParanoidi A0JND3.
KOi K18134.
OMAi DSKRVCF.
OrthoDBi EOG7D2FDQ.
TreeFami TF313716.

Miscellaneous databases

NextBioi 20868679.

Family and domain databases

InterProi IPR007657. Glycosyltransferase_AER61.
[Graphical view ]
Pfami PF04577. DUF563. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiEOGT_BOVIN
AccessioniPrimary (citable) accession number: A0JND3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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