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A0JND3

- EOGT_BOVIN

UniProt

A0JND3 - EOGT_BOVIN

Protein

EGF domain-specific O-linked N-acetylglucosamine transferase

Gene

EOGT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains By similarity.By similarity

    Catalytic activityi

    UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine.
    UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine.

    GO - Molecular functioni

    1. protein N-acetylglucosaminyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. protein O-linked glycosylation Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT61. Glycosyltransferase Family 61.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EGF domain-specific O-linked N-acetylglucosamine transferase (EC:2.4.1.255)
    Alternative name(s):
    Extracellular O-linked N-acetylglucosamine transferase
    Gene namesi
    Name:EOGT
    Synonyms:AER61
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 22

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 527510EGF domain-specific O-linked N-acetylglucosamine transferasePRO_0000301969Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiA0JND3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000030725.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi295 – 2973Required for optimal activityBy similarity
    Motifi524 – 5274Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the glycosyltransferase 61 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG320328.
    GeneTreeiENSGT00750000117715.
    HOGENOMiHOG000033829.
    HOVERGENiHBG056678.
    InParanoidiA0JND3.
    KOiK18134.
    OMAiDSKRVCF.
    OrthoDBiEOG7D2FDQ.
    TreeFamiTF313716.

    Family and domain databases

    InterProiIPR007657. Glycosyltransferase_AER61.
    [Graphical view]
    PfamiPF04577. DUF563. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A0JND3-1 [UniParc]FASTAAdd to Basket

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    MFMLLVFGAL LPEVPLSGQD KAPPQADGIS ATPLFNYASL RLPEEHIPFF    50
    LHNNRHIATV CRKDSHCPYK KYLENLKYCW GYEKSCRPEF RFGYPVCTYV 100
    DMGWTDTLES AQEIFWKQAD FGYAAERLEE LHVLCQPKEK NDSSLVCSRY 150
    LQYCRATNIY LDLRNIKRNH DRFKEDFVQS GEIGGYCKLD IRSLMSQGQR 200
    KSPLQSWFAE LQSYTELNFR PVEDAQCDIV IEKPTYFMKL DAGVNMYHHF 250
    CDFINLYITQ HVNNSFSTDV YVVMWDTSSY GYGDLFSDTW KAFTDYDVIH 300
    LKTYDAKRVC FKEAIFSLLP RMRYGLFYNT PLISGCQNTG LFRAFSQHVL 350
    HRLNITQEGP KGGKIRVTIL ARSTEYRKIL NQNELVNALK TVSTFEVQIV 400
    DYKYKELGFL DQLRITHNTD IFIGMHGAGL THLLFLPDWA AVFELYNCGD 450
    ERCYLDLARL RGVHYITWRR QNKVFPQDKG HHPTLGEHPK FTNYSFDVEE 500
    FMYLVLQAAD YVLQHPKWPF KKKHDEL 527
    Length:527
    Mass (Da):61,749
    Last modified:December 12, 2006 - v1
    Checksum:i1BDB2867FD8D13A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126625 mRNA. Translation: AAI26626.1.
    RefSeqiNP_001071350.1. NM_001077882.1.
    XP_005222695.1. XM_005222638.1.
    XP_005222696.1. XM_005222639.1.
    XP_005222697.1. XM_005222640.1.
    XP_005222698.1. XM_005222641.1.
    UniGeneiBt.21068.

    Genome annotation databases

    EnsembliENSBTAT00000030754; ENSBTAP00000030725; ENSBTAG00000022681.
    GeneIDi508782.
    KEGGibta:508782.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126625 mRNA. Translation: AAI26626.1 .
    RefSeqi NP_001071350.1. NM_001077882.1.
    XP_005222695.1. XM_005222638.1.
    XP_005222696.1. XM_005222639.1.
    XP_005222697.1. XM_005222640.1.
    XP_005222698.1. XM_005222641.1.
    UniGenei Bt.21068.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000030725.

    Protein family/group databases

    CAZyi GT61. Glycosyltransferase Family 61.

    Proteomic databases

    PRIDEi A0JND3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000030754 ; ENSBTAP00000030725 ; ENSBTAG00000022681 .
    GeneIDi 508782.
    KEGGi bta:508782.

    Organism-specific databases

    CTDi 285203.

    Phylogenomic databases

    eggNOGi NOG320328.
    GeneTreei ENSGT00750000117715.
    HOGENOMi HOG000033829.
    HOVERGENi HBG056678.
    InParanoidi A0JND3.
    KOi K18134.
    OMAi DSKRVCF.
    OrthoDBi EOG7D2FDQ.
    TreeFami TF313716.

    Miscellaneous databases

    NextBioi 20868679.

    Family and domain databases

    InterProi IPR007657. Glycosyltransferase_AER61.
    [Graphical view ]
    Pfami PF04577. DUF563. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal skin.

    Entry informationi

    Entry nameiEOGT_BOVIN
    AccessioniPrimary (citable) accession number: A0JND3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3