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Protein

Keratin, type II cytoskeletal 80

Gene

KRT80

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei334Stutter1

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-BTA-6805567 Keratinization
R-BTA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 80
Alternative name(s):
Cytokeratin-80
Short name:
CK-80
Keratin-80
Short name:
K80
Type-II keratin Kb20
Gene namesi
Name:KRT80
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:30742 KRT80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148951 – 422Keratin, type II cytoskeletal 80Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA0JND2
PRIDEiA0JND2

Expressioni

Gene expression databases

BgeeiENSBTAG00000007204

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007288

Structurei

3D structure databases

ProteinModelPortaliA0JND2
SMRiA0JND2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 394IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 82HeadAdd BLAST82
Regioni83 – 118Coil 1AAdd BLAST36
Regioni119 – 135Linker 1Add BLAST17
Regioni136 – 227Coil 1BAdd BLAST92
Regioni228 – 251Linker 12Add BLAST24
Regioni252 – 390Coil 2Add BLAST139
Regioni391 – 422TailAdd BLAST32

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGH5 Eukaryota
ENOG411183I LUCA
GeneTreeiENSGT00910000144169
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiA0JND2
KOiK07605
OMAiMACRSCV
OrthoDBiEOG091G0AOP
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0JND2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACRSCVVGF SSLSSCEVTP AGSPRPATAG WSSCGPPEPG LSSHSLTGCW
60 70 80 90 100
TAGTVSKVTV NPSLLVPLDL KVDPAIQQQK NNEKEEMKVL NDKFASLIGK
110 120 130 140 150
VQALEQRNQL LETRWHFLQS QDSATFDLGH LYEEYQGRLQ EELRKVSKER
160 170 180 190 200
GQLEANLLQV LEKVEDFRIR YEDEISKRTD MEFTFVQLKK DLDAECLRRT
210 220 230 240 250
ELETKLKGLQ SFVELMKSIY EQELKDLAAQ LKDVSVTVGM DSRCHIDLSG
260 270 280 290 300
IVEEVKAQYD AVAARSLEEA EAYSRSQLEE RAACSAEFEN SLQSSRSEIA
310 320 330 340 350
DLNVRIQKLR SQILSIKSHC LKLEENIKVA EEQGELAFQD AKAKLAQLED
360 370 380 390 400
ALQQAKKDMA RQLREYQELM NTKLALDIEI ATYRKLMEGE ESRMDMPSAT
410 420
VVSAVQARCR TAPTLPHPLC SL
Length:422
Mass (Da):47,438
Last modified:December 12, 2006 - v1
Checksum:i180AF4D400CB8E03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126624 mRNA Translation: AAI26625.1
BC147909 mRNA Translation: AAI47910.1
RefSeqiNP_001071420.1, NM_001077952.1
UniGeneiBt.54510

Genome annotation databases

EnsembliENSBTAT00000007288; ENSBTAP00000007288; ENSBTAG00000007204
GeneIDi522400
KEGGibta:522400

Entry informationi

Entry nameiK2C80_BOVIN
AccessioniPrimary (citable) accession number: A0JND2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health