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Protein

Keratin, type II cytoskeletal 80

Gene

KRT80

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei334 – 3341Stutter

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 80
Alternative name(s):
Cytokeratin-80
Short name:
CK-80
Keratin-80
Short name:
K80
Type-II keratin Kb20
Gene namesi
Name:KRT80
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Keratin, type II cytoskeletal 80PRO_0000314895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA0JND2.
PRIDEiA0JND2.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Structurei

3D structure databases

ProteinModelPortaliA0JND2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8282HeadAdd
BLAST
Regioni83 – 390308RodAdd
BLAST
Regioni83 – 11836Coil 1AAdd
BLAST
Regioni119 – 13517Linker 1Add
BLAST
Regioni136 – 22792Coil 1BAdd
BLAST
Regioni228 – 25124Linker 12Add
BLAST
Regioni252 – 390139Coil 2Add
BLAST
Regioni391 – 42232TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGH5. Eukaryota.
ENOG411183I. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA0JND2.
KOiK07605.
OMAiMACRSCV.
OrthoDBiEOG7FV3Q8.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JND2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACRSCVVGF SSLSSCEVTP AGSPRPATAG WSSCGPPEPG LSSHSLTGCW
60 70 80 90 100
TAGTVSKVTV NPSLLVPLDL KVDPAIQQQK NNEKEEMKVL NDKFASLIGK
110 120 130 140 150
VQALEQRNQL LETRWHFLQS QDSATFDLGH LYEEYQGRLQ EELRKVSKER
160 170 180 190 200
GQLEANLLQV LEKVEDFRIR YEDEISKRTD MEFTFVQLKK DLDAECLRRT
210 220 230 240 250
ELETKLKGLQ SFVELMKSIY EQELKDLAAQ LKDVSVTVGM DSRCHIDLSG
260 270 280 290 300
IVEEVKAQYD AVAARSLEEA EAYSRSQLEE RAACSAEFEN SLQSSRSEIA
310 320 330 340 350
DLNVRIQKLR SQILSIKSHC LKLEENIKVA EEQGELAFQD AKAKLAQLED
360 370 380 390 400
ALQQAKKDMA RQLREYQELM NTKLALDIEI ATYRKLMEGE ESRMDMPSAT
410 420
VVSAVQARCR TAPTLPHPLC SL
Length:422
Mass (Da):47,438
Last modified:December 12, 2006 - v1
Checksum:i180AF4D400CB8E03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126624 mRNA. Translation: AAI26625.1.
BC147909 mRNA. Translation: AAI47910.1.
RefSeqiNP_001071420.1. NM_001077952.1.
UniGeneiBt.54510.

Genome annotation databases

EnsembliENSBTAT00000007288; ENSBTAP00000007288; ENSBTAG00000007204.
GeneIDi522400.
KEGGibta:522400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126624 mRNA. Translation: AAI26625.1.
BC147909 mRNA. Translation: AAI47910.1.
RefSeqiNP_001071420.1. NM_001077952.1.
UniGeneiBt.54510.

3D structure databases

ProteinModelPortaliA0JND2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA0JND2.
PRIDEiA0JND2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007288; ENSBTAP00000007288; ENSBTAG00000007204.
GeneIDi522400.
KEGGibta:522400.

Organism-specific databases

CTDi144501.

Phylogenomic databases

eggNOGiENOG410IGH5. Eukaryota.
ENOG411183I. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA0JND2.
KOiK07605.
OMAiMACRSCV.
OrthoDBiEOG7FV3Q8.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiK2C80_BOVIN
AccessioniPrimary (citable) accession number: A0JND2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.