Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type II cytoskeletal 80

Gene

KRT80

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei334Stutter1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-6805567. Keratinization.
R-BTA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 80
Alternative name(s):
Cytokeratin-80
Short name:
CK-80
Keratin-80
Short name:
K80
Type-II keratin Kb20
Gene namesi
Name:KRT80
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148951 – 422Keratin, type II cytoskeletal 80Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA0JND2.
PRIDEiA0JND2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007204.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Structurei

3D structure databases

ProteinModelPortaliA0JND2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 82HeadAdd BLAST82
Regioni83 – 390RodAdd BLAST308
Regioni83 – 118Coil 1AAdd BLAST36
Regioni119 – 135Linker 1Add BLAST17
Regioni136 – 227Coil 1BAdd BLAST92
Regioni228 – 251Linker 12Add BLAST24
Regioni252 – 390Coil 2Add BLAST139
Regioni391 – 422TailAdd BLAST32

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGH5. Eukaryota.
ENOG411183I. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA0JND2.
KOiK07605.
OMAiSCEVTPV.
OrthoDBiEOG091G0AOP.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JND2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACRSCVVGF SSLSSCEVTP AGSPRPATAG WSSCGPPEPG LSSHSLTGCW
60 70 80 90 100
TAGTVSKVTV NPSLLVPLDL KVDPAIQQQK NNEKEEMKVL NDKFASLIGK
110 120 130 140 150
VQALEQRNQL LETRWHFLQS QDSATFDLGH LYEEYQGRLQ EELRKVSKER
160 170 180 190 200
GQLEANLLQV LEKVEDFRIR YEDEISKRTD MEFTFVQLKK DLDAECLRRT
210 220 230 240 250
ELETKLKGLQ SFVELMKSIY EQELKDLAAQ LKDVSVTVGM DSRCHIDLSG
260 270 280 290 300
IVEEVKAQYD AVAARSLEEA EAYSRSQLEE RAACSAEFEN SLQSSRSEIA
310 320 330 340 350
DLNVRIQKLR SQILSIKSHC LKLEENIKVA EEQGELAFQD AKAKLAQLED
360 370 380 390 400
ALQQAKKDMA RQLREYQELM NTKLALDIEI ATYRKLMEGE ESRMDMPSAT
410 420
VVSAVQARCR TAPTLPHPLC SL
Length:422
Mass (Da):47,438
Last modified:December 12, 2006 - v1
Checksum:i180AF4D400CB8E03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126624 mRNA. Translation: AAI26625.1.
BC147909 mRNA. Translation: AAI47910.1.
RefSeqiNP_001071420.1. NM_001077952.1.
UniGeneiBt.54510.

Genome annotation databases

EnsembliENSBTAT00000007288; ENSBTAP00000007288; ENSBTAG00000007204.
GeneIDi522400.
KEGGibta:522400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126624 mRNA. Translation: AAI26625.1.
BC147909 mRNA. Translation: AAI47910.1.
RefSeqiNP_001071420.1. NM_001077952.1.
UniGeneiBt.54510.

3D structure databases

ProteinModelPortaliA0JND2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA0JND2.
PRIDEiA0JND2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007288; ENSBTAP00000007288; ENSBTAG00000007204.
GeneIDi522400.
KEGGibta:522400.

Organism-specific databases

CTDi144501.

Phylogenomic databases

eggNOGiENOG410IGH5. Eukaryota.
ENOG411183I. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiA0JND2.
KOiK07605.
OMAiSCEVTPV.
OrthoDBiEOG091G0AOP.
TreeFamiTF317854.

Enzyme and pathway databases

ReactomeiR-BTA-6805567. Keratinization.
R-BTA-6809371. Formation of the cornified envelope.

Gene expression databases

BgeeiENSBTAG00000007204.

Family and domain databases

InterProiIPR001664. IF.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C80_BOVIN
AccessioniPrimary (citable) accession number: A0JND2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: November 30, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.