Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)

Gene

HIF1A

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Enzyme and pathway databases

ReactomeiR-BTA-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
R-BTA-1234162. Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha.
R-BTA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.

Names & Taxonomyi

Protein namesi
Submitted name:
Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)Imported
Submitted name:
Hypoxia-inducible factor 1-alphaImported
Gene namesi
Name:HIF1AImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027885.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 7054BHLH (basic helix-loop-helix)InterPro annotationAdd
BLAST
Domaini93 – 15866PAS (PER-ARNT-SIM)InterPro annotationAdd
BLAST
Domaini247 – 29852PAS (PER-ARNT-SIM)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation
Contains PAS (PER-ARNT-SIM) domains.SAAS annotation
Contains bHLH (basic helix-loop-helix) domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
HOVERGENiHBG060456.
KOiK08268.
OMAiYCFDVDS.
OrthoDBiEOG7JDQX8.
TreeFamiTF317772.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR001321. HIF-1_alpha.
IPR014887. HIF-1_TAD_C.
IPR021537. HIF_alpha_subunit.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF11413. HIF-1. 1 hit.
PF08778. HIF-1a_CTAD. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
PRINTSiPR01080. HYPOXIAIF1A.
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JND0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGAGGANDK KKISSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV
60 70 80 90 100
SSHLDKASVM RLTISYLRVR KLLDAGDLDI EDEMKAQMNC FYLKALDGFV
110 120 130 140 150
MVLTDDGDMI YISDNVNKYM GLTQFELTGH SVFDFTHPCD HEEMREMLTH
160 170 180 190 200
RNGLVKKGKE QNTQRSFFLR MKCTLTSRGR TMNIKSATWK VLHCTGHIHV
210 220 230 240 250
YDTNSNQSQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK TFLSRHSLDM
260 270 280 290 300
KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV
310 320 330 340 350
TTGQYRMLAK RGGYVWIETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL
360 370 380 390 400
IFSLQQTECV LKPVESSDMK MTQLFTKVES EDTSSLFDKL KKEPDALTLL
410 420 430 440 450
APAAGDTIIS LDFGSNDTET DDQQLEEVPL YNDVMLPSSN EKLQNINLAM
460 470 480 490 500
SPLPASETPK PLRSSADPAL NQEVALKLEP NPESLELSFT MPQIQDQPAS
510 520 530 540 550
PSDGSTRQSS PEPNSPSEYC FDVDSDMVNE FKLELVEKLF AEDTEAKNPF
560 570 580 590 600
STQDTDLDLE MLAPYIPMDD DFQLRSFDQL SPLENSSTSP QSASTNTVFQ
610 620 630 640 650
PTQMQEPPIA TVTTTATSDE LKTVTKDGME DIKILIAFPS PPHVPKEPPC
660 670 680 690 700
ATTSPYSDTG SRTASPNRAG KGVIEQTEKS HPRSPNVLSV ALSQRTTAPE
710 720 730 740 750
EELNPKILAL QNAQRKRKIE HDGSLFQAVG IGTLLQQPDD RATTTSLSWK
760 770 780 790 800
RVKGCKSSEQ NGMEQKTIIL IPSDLACRLL GQSMDESGLP QLTSYDCEVN
810 820
APIQGSRNLL QGEELLRALD QVN
Length:823
Mass (Da):92,129
Last modified:December 12, 2006 - v1
Checksum:iA6E388E4FEA15705
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02029320 Genomic DNA. No translation available.
BC126622 mRNA. Translation: AAI26623.1.
RefSeqiNP_776764.2. NM_174339.3.
UniGeneiBt.4184.

Genome annotation databases

EnsembliENSBTAT00000027885; ENSBTAP00000027885; ENSBTAG00000020935.
GeneIDi281814.
KEGGibta:281814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02029320 Genomic DNA. No translation available.
BC126622 mRNA. Translation: AAI26623.1.
RefSeqiNP_776764.2. NM_174339.3.
UniGeneiBt.4184.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027885; ENSBTAP00000027885; ENSBTAG00000020935.
GeneIDi281814.
KEGGibta:281814.

Organism-specific databases

CTDi3091.

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
HOVERGENiHBG060456.
KOiK08268.
OMAiYCFDVDS.
OrthoDBiEOG7JDQX8.
TreeFamiTF317772.

Enzyme and pathway databases

ReactomeiR-BTA-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
R-BTA-1234162. Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha.
R-BTA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.

Miscellaneous databases

NextBioi20805726.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR001321. HIF-1_alpha.
IPR014887. HIF-1_TAD_C.
IPR021537. HIF_alpha_subunit.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF11413. HIF-1. 1 hit.
PF08778. HIF-1a_CTAD. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
PRINTSiPR01080. HYPOXIAIF1A.
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 2 hits.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: L1 HerefordImported.
    Tissue: Fetal muscleImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. Ensembl
    Submitted (MAR-2016) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiA0JND0_BOVIN
AccessioniPrimary (citable) accession number: A0JND0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.