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Protein
Submitted name:

Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)

Gene

HIF1A

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulationSAAS annotation

Enzyme and pathway databases

ReactomeiR-BTA-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-BTA-1234162 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
R-BTA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-BTA-5689880 Ub-specific processing proteases
R-BTA-8857538 PTK6 promotes HIF1A stabilization
R-BTA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Submitted name:
Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)Imported
Submitted name:
Hypoxia-inducible factor 1-alphaImported
Gene namesi
Name:HIF1AImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:29848 HIF1A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4024-hydroxyprolineUniRule annotation1
Modified residuei5644-hydroxyprolineUniRule annotation1
Modified residuei800(3S)-3-hydroxyasparagineUniRule annotation1

Proteomic databases

PRIDEiA0JND0

Expressioni

Gene expression databases

BgeeiENSBTAG00000020935

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiA0JND0, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 70BHLHInterPro annotationAdd BLAST54
Domaini93 – 158PASInterPro annotationAdd BLAST66
Domaini247 – 298PASInterPro annotationAdd BLAST52

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG3558 Eukaryota
ENOG410YK57 LUCA
GeneTreeiENSGT00760000118788
HOVERGENiHBG060456
KOiK08268
OMAiYCFDVDS
OrthoDBiEOG091G0486
TreeFamiTF317772

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR001321 HIF-1_alpha
IPR014887 HIF-1_TAD_C
IPR021537 HIF_alpha_subunit
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
PfamiView protein in Pfam
PF11413 HIF-1, 1 hit
PF08778 HIF-1a_CTAD, 1 hit
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
PRINTSiPR01080 HYPOXIAIF1A
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
TIGRFAMsiTIGR00229 sensory_box, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

Sequencei

Sequence statusi: Complete.

A0JND0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGAGGANDK KKISSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV
60 70 80 90 100
SSHLDKASVM RLTISYLRVR KLLDAGDLDI EDEMKAQMNC FYLKALDGFV
110 120 130 140 150
MVLTDDGDMI YISDNVNKYM GLTQFELTGH SVFDFTHPCD HEEMREMLTH
160 170 180 190 200
RNGLVKKGKE QNTQRSFFLR MKCTLTSRGR TMNIKSATWK VLHCTGHIHV
210 220 230 240 250
YDTNSNQSQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK TFLSRHSLDM
260 270 280 290 300
KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV
310 320 330 340 350
TTGQYRMLAK RGGYVWIETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL
360 370 380 390 400
IFSLQQTECV LKPVESSDMK MTQLFTKVES EDTSSLFDKL KKEPDALTLL
410 420 430 440 450
APAAGDTIIS LDFGSNDTET DDQQLEEVPL YNDVMLPSSN EKLQNINLAM
460 470 480 490 500
SPLPASETPK PLRSSADPAL NQEVALKLEP NPESLELSFT MPQIQDQPAS
510 520 530 540 550
PSDGSTRQSS PEPNSPSEYC FDVDSDMVNE FKLELVEKLF AEDTEAKNPF
560 570 580 590 600
STQDTDLDLE MLAPYIPMDD DFQLRSFDQL SPLENSSTSP QSASTNTVFQ
610 620 630 640 650
PTQMQEPPIA TVTTTATSDE LKTVTKDGME DIKILIAFPS PPHVPKEPPC
660 670 680 690 700
ATTSPYSDTG SRTASPNRAG KGVIEQTEKS HPRSPNVLSV ALSQRTTAPE
710 720 730 740 750
EELNPKILAL QNAQRKRKIE HDGSLFQAVG IGTLLQQPDD RATTTSLSWK
760 770 780 790 800
RVKGCKSSEQ NGMEQKTIIL IPSDLACRLL GQSMDESGLP QLTSYDCEVN
810 820
APIQGSRNLL QGEELLRALD QVN
Length:823
Mass (Da):92,129
Last modified:December 12, 2006 - v1
Checksum:iA6E388E4FEA15705
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02029320 Genomic DNA No translation available.
BC126622 mRNA Translation: AAI26623.1
RefSeqiNP_776764.2, NM_174339.3
UniGeneiBt.4184

Genome annotation databases

EnsembliENSBTAT00000027885; ENSBTAP00000027885; ENSBTAG00000020935
GeneIDi281814
KEGGibta:281814

Similar proteinsi

Entry informationi

Entry nameiA0JND0_BOVIN
AccessioniPrimary (citable) accession number: A0JND0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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