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A0JNC1

- CDS2_BOVIN

UniProt

A0JNC1 - CDS2_BOVIN

Protein

Phosphatidate cytidylyltransferase 2

Gene

CDS2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.By similarity

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_206590. Synthesis of PG.
    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase 2 (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase 2
    CDP-DG synthase 2
    CDP-diacylglycerol synthase 2
    Short name:
    CDS 2
    CDP-diglyceride pyrophosphorylase 2
    CDP-diglyceride synthase 2
    CTP:phosphatidate cytidylyltransferase 2
    Gene namesi
    Name:CDS2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 13

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Phosphatidate cytidylyltransferase 2PRO_0000304876Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211Phosphoserine
    Modified residuei33 – 331PhosphoserineBy similarity
    Modified residuei35 – 351PhosphoserineBy similarity
    Modified residuei37 – 371PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiA0JNC1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000007970.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei340 – 36021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    GeneTreeiENSGT00390000016175.
    HOGENOMiHOG000209582.
    HOVERGENiHBG002485.
    InParanoidiA0JNC1.
    KOiK00981.
    OMAiRILTYFV.
    OrthoDBiEOG7M98G5.
    TreeFamiTF313464.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JNC1-1 [UniParc]FASTAAdd to Basket

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    MTELRQRVAR EPEAPPEDKE SESEAKADGE TASDSESRVE AVTQPPSADD    50
    TPEVLNRALS NLSSRWKNWW VRGILTLAMI AFFFIIIYLG PMVLMMIVMC 100
    VQIKCFHEII TIGYNVYHSY DLPWFRTLSW YFLLCVNYFF YGETVTDYFF 150
    TLVQREEPLR ILSKYHRFIS FTLYLTGFCM FVLSLVKKHY RLQFYMFGWT 200
    HVTLLIVVTQ SHLVIHNLFE GMIWFIVPIS CVICNDIMAY MFGFFFGRTP 250
    LIKLSPKKTW EGFIGGFFAT VVFGLLLSYV MSGYRCFVCP VEYNNDTNSF 300
    TVDCEPSGLF RLQEYNIPGV IQSIIGWKTV RMYPFQIHSI ALSTFASLIG 350
    PFGGFFASGF KRAFKIKDFA NTIPGHGGIM DRFDCQYLMA TFVNVYIASF 400
    IRGPNPSKLV QQFLTLRPDQ QLHIFNTLKS HLTDKGMLTA ATEDK 445
    Length:445
    Mass (Da):51,357
    Last modified:December 12, 2006 - v1
    Checksum:i788FC1B80D41902E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126607 mRNA. Translation: AAI26608.1.
    RefSeqiNP_001071514.1. NM_001078046.1.
    UniGeneiBt.2342.

    Genome annotation databases

    EnsembliENSBTAT00000007970; ENSBTAP00000007970; ENSBTAG00000006066.
    GeneIDi614834.
    KEGGibta:614834.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126607 mRNA. Translation: AAI26608.1 .
    RefSeqi NP_001071514.1. NM_001078046.1.
    UniGenei Bt.2342.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000007970.

    Proteomic databases

    PRIDEi A0JNC1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000007970 ; ENSBTAP00000007970 ; ENSBTAG00000006066 .
    GeneIDi 614834.
    KEGGi bta:614834.

    Organism-specific databases

    CTDi 8760.

    Phylogenomic databases

    eggNOGi COG0575.
    GeneTreei ENSGT00390000016175.
    HOGENOMi HOG000209582.
    HOVERGENi HBG002485.
    InParanoidi A0JNC1.
    KOi K00981.
    OMAi RILTYFV.
    OrthoDBi EOG7M98G5.
    TreeFami TF313464.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .
    Reactomei REACT_206590. Synthesis of PG.

    Miscellaneous databases

    NextBioi 20899310.

    Family and domain databases

    InterProi IPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiCDS2_BOVIN
    AccessioniPrimary (citable) accession number: A0JNC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3