Reviewed, UniProtKB/Swiss-Prot A0JNC1 (CDS2_BOVIN)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase 2
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase 2
    CDP-diglyceride synthetase 2
    CDP-diacylglycerol synthase 2
      Short name=CDS 2
    CTP:phosphatidate cytidylyltransferase 2
    CDP-DG synthetase 2
    CDP-DAG synthase 2

Gene names

Name:

CDS2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin By similarity.
Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side Potential.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Phosphatidate cytidylyltransferase 2		PRO_0000304876
Regions
	Transmembrane	79 – 99	21	Potential
	Transmembrane	132 – 152	21	Potential
	Transmembrane	166 – 186	21	Potential
	Transmembrane	213 – 233	21	Potential
	Transmembrane	262 – 282	21	Potential
	Transmembrane	340 – 360	21	Potential
Amino acid modifications
	Modified residue	21	1	Phosphoserine
	Modified residue	23	1	Phosphoserine By similarity
	Modified residue	31	1	Phosphothreonine By similarity
	Modified residue	33	1	Phosphoserine By similarity
	Modified residue	37	1	Phosphoserine By similarity
	Modified residue	47	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0JNC1-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 788FC1B80D41902E	FASTA	445	51,357
	10 20 30 40 50 60 MTELRQRVAR EPEAPPEDKE SESEAKADGE TASDSESRVE AVTQPPSADD TPEVLNRALS 70 80 90 100 110 120 NLSSRWKNWW VRGILTLAMI AFFFIIIYLG PMVLMMIVMC VQIKCFHEII TIGYNVYHSY 130 140 150 160 170 180 DLPWFRTLSW YFLLCVNYFF YGETVTDYFF TLVQREEPLR ILSKYHRFIS FTLYLTGFCM 190 200 210 220 230 240 FVLSLVKKHY RLQFYMFGWT HVTLLIVVTQ SHLVIHNLFE GMIWFIVPIS CVICNDIMAY 250 260 270 280 290 300 MFGFFFGRTP LIKLSPKKTW EGFIGGFFAT VVFGLLLSYV MSGYRCFVCP VEYNNDTNSF 310 320 330 340 350 360 TVDCEPSGLF RLQEYNIPGV IQSIIGWKTV RMYPFQIHSI ALSTFASLIG PFGGFFASGF 370 380 390 400 410 420 KRAFKIKDFA NTIPGHGGIM DRFDCQYLMA TFVNVYIASF IRGPNPSKLV QQFLTLRPDQ 430 440 QLHIFNTLKS HLTDKGMLTA ATEDK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hippocampus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC126607 mRNA. Translation: AAI26608.1.
IPI	IPI00698778.
RefSeq	NP_001071514.1.
UniGene	Bt.2342
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000007970; ENSBTAP00000007970; ENSBTAG00000006066; Bos taurus. [Genome view]
GeneID	614834.
KEGG	bta:614834.
Organism-specific databases
CTD	614834.
Phylogenomic databases
HOVERGEN	A0JNC1.
OMA	PDQQLHI.
Enzyme and pathway databases
BRENDA	2.7.7.41. 251.
Family and domain databases
InterPro	IPR000374. PC_trans. IPR016720. PC_Trfase_euk. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PIRSF	PIRSF018269. PC_trans_euk. 1 hit.
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDS2_BOVIN

Accession

Primary (citable) accession number: A0JNC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)