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A0JNC1 (CDS2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidate cytidylyltransferase 2
EC=2.7.7.41
Alternative name(s):
CDP-DAG synthase 2
CDP-DG synthase 2
CDP-diacylglycerol synthase 2
Short name=CDS 2
CDP-diglyceride pyrophosphorylase 2
CDP-diglyceride synthase 2
CTP:phosphatidate cytidylyltransferase 2
Gene names
Name:CDS2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin By similarity.

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side Potential.

Sequence similarities

Belongs to the CDS family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Phosphatidate cytidylyltransferase 2
PRO_0000304876

Regions

Transmembrane79 – 9921Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane166 – 18621Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane262 – 28221Helical; Potential
Transmembrane340 – 36021Helical; Potential

Amino acid modifications

Modified residue211Phosphoserine
Modified residue311Phosphothreonine By similarity
Modified residue331Phosphoserine By similarity
Modified residue351Phosphoserine By similarity
Modified residue371Phosphoserine By similarity
Modified residue471Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A0JNC1 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 788FC1B80D41902E

FASTA44551,357
        10         20         30         40         50         60 
MTELRQRVAR EPEAPPEDKE SESEAKADGE TASDSESRVE AVTQPPSADD TPEVLNRALS 

        70         80         90        100        110        120 
NLSSRWKNWW VRGILTLAMI AFFFIIIYLG PMVLMMIVMC VQIKCFHEII TIGYNVYHSY 

       130        140        150        160        170        180 
DLPWFRTLSW YFLLCVNYFF YGETVTDYFF TLVQREEPLR ILSKYHRFIS FTLYLTGFCM 

       190        200        210        220        230        240 
FVLSLVKKHY RLQFYMFGWT HVTLLIVVTQ SHLVIHNLFE GMIWFIVPIS CVICNDIMAY 

       250        260        270        280        290        300 
MFGFFFGRTP LIKLSPKKTW EGFIGGFFAT VVFGLLLSYV MSGYRCFVCP VEYNNDTNSF 

       310        320        330        340        350        360 
TVDCEPSGLF RLQEYNIPGV IQSIIGWKTV RMYPFQIHSI ALSTFASLIG PFGGFFASGF 

       370        380        390        400        410        420 
KRAFKIKDFA NTIPGHGGIM DRFDCQYLMA TFVNVYIASF IRGPNPSKLV QQFLTLRPDQ 

       430        440 
QLHIFNTLKS HLTDKGMLTA ATEDK

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hippocampus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC126607 mRNA. Translation: AAI26608.1.
IPIIPI00698778.
RefSeqNP_001071514.1. NM_001078046.1.
UniGeneBt.2342.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000007970.

Proteomic databases

PRIDEA0JNC1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000007970; ENSBTAP00000007970; ENSBTAG00000006066.
GeneID614834.
KEGGbta:614834.

Organism-specific databases

CTD8760.

Phylogenomic databases

eggNOGCOG0575.
GeneTreeENSGT00390000016175.
HOGENOMHOG000209582.
HOVERGENHBG002485.
InParanoidA0JNC1.
KOK00981.
OMAAMITFFF.
OrthoDBEOG4V437K.

Enzyme and pathway databases

UniPathwayUPA00557; UER00614.

Family and domain databases

InterProIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFPIRSF018269. PC_trans_euk. 1 hit.
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20899310.

Entry information

Entry nameCDS2_BOVIN
AccessionPrimary (citable) accession number: A0JNC1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 12, 2006
Last modified: April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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