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A0JNB1

- ZN227_BOVIN

UniProt

A0JNB1 - ZN227_BOVIN

Protein

Zinc finger protein 227

Gene

ZNF227

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri243 – 27533C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri508 – 53023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri536 – 55823C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri564 – 58623C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri592 – 61423C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri620 – 64223C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri648 – 67023C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri676 – 69823C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri704 – 72623C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri732 – 75423C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri760 – 78223C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 227
    Gene namesi
    Name:ZNF227
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 787787Zinc finger protein 227PRO_0000284139Add
    BLAST

    Proteomic databases

    PRIDEiA0JNB1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000017798.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JNB1.
    SMRiA0JNB1. Positions 310-785.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 9472KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri243 – 27533C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri312 – 33423C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri508 – 53023C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri536 – 55823C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri564 – 58623C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri592 – 61423C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri620 – 64223C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri648 – 67023C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri676 – 69823C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri704 – 72623C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri732 – 75423C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri760 – 78223C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117393.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiA0JNB1.
    KOiK09228.
    OMAiRLTYHQK.

    Family and domain databases

    Gene3Di3.30.160.60. 18 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 18 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 17 hits.
    PS50157. ZINC_FINGER_C2H2_2. 17 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JNB1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSQDSDFPQ KEHEKMTEFQ EAVTFKDVAV VFTEEELGLL DSAQRKLYQD    50
    VMVENFRNLV SVGHVPFKAD MVSQLETEEK LWTMERETQR NGHSSEIHSA 100
    VTSGSKIPNE METLGKVMFK YLSCEELSCW QIWKHTTNDL TLQRKSSWFL 150
    HGDSLQVSED ENHIMNHKGD HFGCLENQEF LIPTAQASCG SRCLSESENP 200
    SRGKQMSVKN HLHVCEGFTK NSPLSDPGKT DAKQTPCKGE RPHPCRVCGE 250
    GFSHGAVLPV HQVDPGEKCS HLQTHQRIHP GGTVNKCPKS GDGFHQNSFH 300
    PHHSNPTGEK SYRCDSCGKA FGSSTGLIIH YRTHTGEKPY RCEACGKCFS 350
    QSSNFQCHQR VHTEEKPYKC EECGKGFGWS VNLRVHQRVH RGEKPYKCEE 400
    CGKGFTQAAH YHIHQRVHTG EKPYKCDVCG KGFSHNSPLI CHRRVHTGEK 450
    PYRCEACGKG FTRNTDLHIH FRVHTGEKPY TCKECGKGFS QASNLQVHQN 500
    VHTGEKRFKC ETCGKGFSQS SKLQTHQRVH TGEKPYRCDV CGKDFSYSSN 550
    LKLHQVIHTG EKPYTCEACG KGFSWRSNLH AHQRVHSGEK PYKCEACDKS 600
    FSQAIDFRVH QRVHTGEKPY KCGVCGKGFS QSSGLQSHQR VHTGEKPYKC 650
    DVCGKGFRYS SQFIYHQRGH TGEKPYKCEE CGKGFGRSLN LRHHQRVHTG 700
    EKPHKCEECG KAFSLPSNLR VHLSVHTREK LFKCEDCGKG FSQSSRLQAH 750
    QRVHTGEKPY KCNICGKDFS HRSRLTYHQK VHTGKNL 787
    Length:787
    Mass (Da):89,360
    Last modified:December 12, 2006 - v1
    Checksum:i2CDAA23D2ADD56FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126592 mRNA. Translation: AAI26593.1.
    RefSeqiNP_001071428.1. NM_001077960.1.
    UniGeneiBt.62016.

    Genome annotation databases

    EnsembliENSBTAT00000017798; ENSBTAP00000017798; ENSBTAG00000027431.
    GeneIDi524111.
    KEGGibta:524111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126592 mRNA. Translation: AAI26593.1 .
    RefSeqi NP_001071428.1. NM_001077960.1.
    UniGenei Bt.62016.

    3D structure databases

    ProteinModelPortali A0JNB1.
    SMRi A0JNB1. Positions 310-785.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000017798.

    Proteomic databases

    PRIDEi A0JNB1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000017798 ; ENSBTAP00000017798 ; ENSBTAG00000027431 .
    GeneIDi 524111.
    KEGGi bta:524111.

    Organism-specific databases

    CTDi 7770.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117393.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi A0JNB1.
    KOi K09228.
    OMAi RLTYHQK.

    Miscellaneous databases

    NextBioi 20873891.

    Family and domain databases

    Gene3Di 3.30.160.60. 18 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 18 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 17 hits.
    PS50157. ZINC_FINGER_C2H2_2. 17 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal cerebellum.

    Entry informationi

    Entry nameiZN227_BOVIN
    AccessioniPrimary (citable) accession number: A0JNB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3