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A0JNB1

- ZN227_BOVIN

UniProt

A0JNB1 - ZN227_BOVIN

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Protein
Zinc finger protein 227
Gene
ZNF227
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri243 – 27533C2H2-type 1
Add
BLAST
Zinc fingeri312 – 33423C2H2-type 2
Add
BLAST
Zinc fingeri340 – 36223C2H2-type 3
Add
BLAST
Zinc fingeri368 – 39023C2H2-type 4
Add
BLAST
Zinc fingeri396 – 41823C2H2-type 5
Add
BLAST
Zinc fingeri424 – 44623C2H2-type 6
Add
BLAST
Zinc fingeri452 – 47423C2H2-type 7
Add
BLAST
Zinc fingeri480 – 50223C2H2-type 8
Add
BLAST
Zinc fingeri508 – 53023C2H2-type 9
Add
BLAST
Zinc fingeri536 – 55823C2H2-type 10
Add
BLAST
Zinc fingeri564 – 58623C2H2-type 11
Add
BLAST
Zinc fingeri592 – 61423C2H2-type 12
Add
BLAST
Zinc fingeri620 – 64223C2H2-type 13
Add
BLAST
Zinc fingeri648 – 67023C2H2-type 14
Add
BLAST
Zinc fingeri676 – 69823C2H2-type 15
Add
BLAST
Zinc fingeri704 – 72623C2H2-type 16
Add
BLAST
Zinc fingeri732 – 75423C2H2-type 17
Add
BLAST
Zinc fingeri760 – 78223C2H2-type 18
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 227
Gene namesi
Name:ZNF227
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 787787Zinc finger protein 227
PRO_0000284139Add
BLAST

Proteomic databases

PRIDEiA0JNB1.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017798.

Structurei

3D structure databases

ProteinModelPortaliA0JNB1.
SMRiA0JNB1. Positions 310-785.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 9472KRAB
Add
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117393.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA0JNB1.
KOiK09228.
OMAiRLTYHQK.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JNB1-1 [UniParc]FASTAAdd to Basket

« Hide

MPSQDSDFPQ KEHEKMTEFQ EAVTFKDVAV VFTEEELGLL DSAQRKLYQD    50
VMVENFRNLV SVGHVPFKAD MVSQLETEEK LWTMERETQR NGHSSEIHSA 100
VTSGSKIPNE METLGKVMFK YLSCEELSCW QIWKHTTNDL TLQRKSSWFL 150
HGDSLQVSED ENHIMNHKGD HFGCLENQEF LIPTAQASCG SRCLSESENP 200
SRGKQMSVKN HLHVCEGFTK NSPLSDPGKT DAKQTPCKGE RPHPCRVCGE 250
GFSHGAVLPV HQVDPGEKCS HLQTHQRIHP GGTVNKCPKS GDGFHQNSFH 300
PHHSNPTGEK SYRCDSCGKA FGSSTGLIIH YRTHTGEKPY RCEACGKCFS 350
QSSNFQCHQR VHTEEKPYKC EECGKGFGWS VNLRVHQRVH RGEKPYKCEE 400
CGKGFTQAAH YHIHQRVHTG EKPYKCDVCG KGFSHNSPLI CHRRVHTGEK 450
PYRCEACGKG FTRNTDLHIH FRVHTGEKPY TCKECGKGFS QASNLQVHQN 500
VHTGEKRFKC ETCGKGFSQS SKLQTHQRVH TGEKPYRCDV CGKDFSYSSN 550
LKLHQVIHTG EKPYTCEACG KGFSWRSNLH AHQRVHSGEK PYKCEACDKS 600
FSQAIDFRVH QRVHTGEKPY KCGVCGKGFS QSSGLQSHQR VHTGEKPYKC 650
DVCGKGFRYS SQFIYHQRGH TGEKPYKCEE CGKGFGRSLN LRHHQRVHTG 700
EKPHKCEECG KAFSLPSNLR VHLSVHTREK LFKCEDCGKG FSQSSRLQAH 750
QRVHTGEKPY KCNICGKDFS HRSRLTYHQK VHTGKNL 787
Length:787
Mass (Da):89,360
Last modified:December 12, 2006 - v1
Checksum:i2CDAA23D2ADD56FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126592 mRNA. Translation: AAI26593.1.
RefSeqiNP_001071428.1. NM_001077960.1.
UniGeneiBt.62016.

Genome annotation databases

EnsembliENSBTAT00000017798; ENSBTAP00000017798; ENSBTAG00000027431.
GeneIDi524111.
KEGGibta:524111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126592 mRNA. Translation: AAI26593.1 .
RefSeqi NP_001071428.1. NM_001077960.1.
UniGenei Bt.62016.

3D structure databases

ProteinModelPortali A0JNB1.
SMRi A0JNB1. Positions 310-785.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000017798.

Proteomic databases

PRIDEi A0JNB1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000017798 ; ENSBTAP00000017798 ; ENSBTAG00000027431 .
GeneIDi 524111.
KEGGi bta:524111.

Organism-specific databases

CTDi 7770.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00750000117393.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi A0JNB1.
KOi K09228.
OMAi RLTYHQK.

Miscellaneous databases

NextBioi 20873891.

Family and domain databases

Gene3Di 3.30.160.60. 18 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiZN227_BOVIN
AccessioniPrimary (citable) accession number: A0JNB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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