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A0JNB1

- ZN227_BOVIN

UniProt

A0JNB1 - ZN227_BOVIN

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Protein

Zinc finger protein 227

Gene

ZNF227

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri243 – 27533C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri536 – 55823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri564 – 58623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri592 – 61423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri620 – 64223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri648 – 67023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri676 – 69823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri704 – 72623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri732 – 75423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri760 – 78223C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 227
Gene namesi
Name:ZNF227
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 787787Zinc finger protein 227PRO_0000284139Add
BLAST

Proteomic databases

PRIDEiA0JNB1.

Expressioni

Gene expression databases

ExpressionAtlasiA0JNB1. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017798.

Structurei

3D structure databases

ProteinModelPortaliA0JNB1.
SMRiA0JNB1. Positions 310-785.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 9472KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri243 – 27533C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri536 – 55823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri564 – 58623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri592 – 61423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri620 – 64223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri648 – 67023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri676 – 69823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri704 – 72623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri732 – 75423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri760 – 78223C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120469.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA0JNB1.
KOiK09228.
OMAiRLTYHQK.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JNB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSQDSDFPQ KEHEKMTEFQ EAVTFKDVAV VFTEEELGLL DSAQRKLYQD
60 70 80 90 100
VMVENFRNLV SVGHVPFKAD MVSQLETEEK LWTMERETQR NGHSSEIHSA
110 120 130 140 150
VTSGSKIPNE METLGKVMFK YLSCEELSCW QIWKHTTNDL TLQRKSSWFL
160 170 180 190 200
HGDSLQVSED ENHIMNHKGD HFGCLENQEF LIPTAQASCG SRCLSESENP
210 220 230 240 250
SRGKQMSVKN HLHVCEGFTK NSPLSDPGKT DAKQTPCKGE RPHPCRVCGE
260 270 280 290 300
GFSHGAVLPV HQVDPGEKCS HLQTHQRIHP GGTVNKCPKS GDGFHQNSFH
310 320 330 340 350
PHHSNPTGEK SYRCDSCGKA FGSSTGLIIH YRTHTGEKPY RCEACGKCFS
360 370 380 390 400
QSSNFQCHQR VHTEEKPYKC EECGKGFGWS VNLRVHQRVH RGEKPYKCEE
410 420 430 440 450
CGKGFTQAAH YHIHQRVHTG EKPYKCDVCG KGFSHNSPLI CHRRVHTGEK
460 470 480 490 500
PYRCEACGKG FTRNTDLHIH FRVHTGEKPY TCKECGKGFS QASNLQVHQN
510 520 530 540 550
VHTGEKRFKC ETCGKGFSQS SKLQTHQRVH TGEKPYRCDV CGKDFSYSSN
560 570 580 590 600
LKLHQVIHTG EKPYTCEACG KGFSWRSNLH AHQRVHSGEK PYKCEACDKS
610 620 630 640 650
FSQAIDFRVH QRVHTGEKPY KCGVCGKGFS QSSGLQSHQR VHTGEKPYKC
660 670 680 690 700
DVCGKGFRYS SQFIYHQRGH TGEKPYKCEE CGKGFGRSLN LRHHQRVHTG
710 720 730 740 750
EKPHKCEECG KAFSLPSNLR VHLSVHTREK LFKCEDCGKG FSQSSRLQAH
760 770 780
QRVHTGEKPY KCNICGKDFS HRSRLTYHQK VHTGKNL
Length:787
Mass (Da):89,360
Last modified:December 12, 2006 - v1
Checksum:i2CDAA23D2ADD56FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126592 mRNA. Translation: AAI26593.1.
RefSeqiNP_001071428.1. NM_001077960.1.
UniGeneiBt.62016.

Genome annotation databases

EnsembliENSBTAT00000017798; ENSBTAP00000017798; ENSBTAG00000027431.
GeneIDi524111.
KEGGibta:524111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126592 mRNA. Translation: AAI26593.1 .
RefSeqi NP_001071428.1. NM_001077960.1.
UniGenei Bt.62016.

3D structure databases

ProteinModelPortali A0JNB1.
SMRi A0JNB1. Positions 310-785.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000017798.

Proteomic databases

PRIDEi A0JNB1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000017798 ; ENSBTAP00000017798 ; ENSBTAG00000027431 .
GeneIDi 524111.
KEGGi bta:524111.

Organism-specific databases

CTDi 7770.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120469.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi A0JNB1.
KOi K09228.
OMAi RLTYHQK.

Miscellaneous databases

NextBioi 20873891.

Gene expression databases

ExpressionAtlasi A0JNB1. baseline.

Family and domain databases

Gene3Di 3.30.160.60. 18 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiZN227_BOVIN
AccessioniPrimary (citable) accession number: A0JNB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 12, 2006
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3