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Protein

Zinc finger protein 227

Gene

ZNF227

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri243 – 275C2H2-type 1PROSITE-ProRule annotationAdd BLAST33
Zinc fingeri312 – 334C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri648 – 670C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri676 – 698C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri704 – 726C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri732 – 754C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri760 – 782C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 227
Gene namesi
Name:ZNF227
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002841391 – 787Zinc finger protein 227Add BLAST787

Proteomic databases

PRIDEiA0JNB1

Expressioni

Gene expression databases

BgeeiENSBTAG00000027431
ExpressionAtlasiA0JNB1 baseline

Structurei

3D structure databases

ProteinModelPortaliA0JNB1
SMRiA0JNB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 94KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri243 – 275C2H2-type 1PROSITE-ProRule annotationAdd BLAST33
Zinc fingeri312 – 334C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri648 – 670C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri676 – 698C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri704 – 726C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri732 – 754C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri760 – 782C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA0JNB1
KOiK09228
OMAiAHFHIHQ

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

Sequencei

Sequence statusi: Complete.

A0JNB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQDSDFPQ KEHEKMTEFQ EAVTFKDVAV VFTEEELGLL DSAQRKLYQD
60 70 80 90 100
VMVENFRNLV SVGHVPFKAD MVSQLETEEK LWTMERETQR NGHSSEIHSA
110 120 130 140 150
VTSGSKIPNE METLGKVMFK YLSCEELSCW QIWKHTTNDL TLQRKSSWFL
160 170 180 190 200
HGDSLQVSED ENHIMNHKGD HFGCLENQEF LIPTAQASCG SRCLSESENP
210 220 230 240 250
SRGKQMSVKN HLHVCEGFTK NSPLSDPGKT DAKQTPCKGE RPHPCRVCGE
260 270 280 290 300
GFSHGAVLPV HQVDPGEKCS HLQTHQRIHP GGTVNKCPKS GDGFHQNSFH
310 320 330 340 350
PHHSNPTGEK SYRCDSCGKA FGSSTGLIIH YRTHTGEKPY RCEACGKCFS
360 370 380 390 400
QSSNFQCHQR VHTEEKPYKC EECGKGFGWS VNLRVHQRVH RGEKPYKCEE
410 420 430 440 450
CGKGFTQAAH YHIHQRVHTG EKPYKCDVCG KGFSHNSPLI CHRRVHTGEK
460 470 480 490 500
PYRCEACGKG FTRNTDLHIH FRVHTGEKPY TCKECGKGFS QASNLQVHQN
510 520 530 540 550
VHTGEKRFKC ETCGKGFSQS SKLQTHQRVH TGEKPYRCDV CGKDFSYSSN
560 570 580 590 600
LKLHQVIHTG EKPYTCEACG KGFSWRSNLH AHQRVHSGEK PYKCEACDKS
610 620 630 640 650
FSQAIDFRVH QRVHTGEKPY KCGVCGKGFS QSSGLQSHQR VHTGEKPYKC
660 670 680 690 700
DVCGKGFRYS SQFIYHQRGH TGEKPYKCEE CGKGFGRSLN LRHHQRVHTG
710 720 730 740 750
EKPHKCEECG KAFSLPSNLR VHLSVHTREK LFKCEDCGKG FSQSSRLQAH
760 770 780
QRVHTGEKPY KCNICGKDFS HRSRLTYHQK VHTGKNL
Length:787
Mass (Da):89,360
Last modified:December 12, 2006 - v1
Checksum:i2CDAA23D2ADD56FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126592 mRNA Translation: AAI26593.1
RefSeqiNP_001071428.1, NM_001077960.1
UniGeneiBt.62016

Genome annotation databases

EnsembliENSBTAT00000017798; ENSBTAP00000017798; ENSBTAG00000027431
GeneIDi524111
KEGGibta:524111

Similar proteinsi

Entry informationi

Entry nameiZN227_BOVIN
AccessioniPrimary (citable) accession number: A0JNB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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