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A0JNB1 (ZN227_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Zinc finger protein 227
Gene names
Name:ZNF227
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length787 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 18 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 787787Zinc finger protein 227
PRO_0000284139

Regions

Domain23 – 9472KRAB
Zinc finger243 – 27533C2H2-type 1
Zinc finger312 – 33423C2H2-type 2
Zinc finger340 – 36223C2H2-type 3
Zinc finger368 – 39023C2H2-type 4
Zinc finger396 – 41823C2H2-type 5
Zinc finger424 – 44623C2H2-type 6
Zinc finger452 – 47423C2H2-type 7
Zinc finger480 – 50223C2H2-type 8
Zinc finger508 – 53023C2H2-type 9
Zinc finger536 – 55823C2H2-type 10
Zinc finger564 – 58623C2H2-type 11
Zinc finger592 – 61423C2H2-type 12
Zinc finger620 – 64223C2H2-type 13
Zinc finger648 – 67023C2H2-type 14
Zinc finger676 – 69823C2H2-type 15
Zinc finger704 – 72623C2H2-type 16
Zinc finger732 – 75423C2H2-type 17
Zinc finger760 – 78223C2H2-type 18

Sequences

Sequence LengthMass (Da)Tools
A0JNB1 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 2CDAA23D2ADD56FC

FASTA78789,360
        10         20         30         40         50         60 
MPSQDSDFPQ KEHEKMTEFQ EAVTFKDVAV VFTEEELGLL DSAQRKLYQD VMVENFRNLV 

        70         80         90        100        110        120 
SVGHVPFKAD MVSQLETEEK LWTMERETQR NGHSSEIHSA VTSGSKIPNE METLGKVMFK 

       130        140        150        160        170        180 
YLSCEELSCW QIWKHTTNDL TLQRKSSWFL HGDSLQVSED ENHIMNHKGD HFGCLENQEF 

       190        200        210        220        230        240 
LIPTAQASCG SRCLSESENP SRGKQMSVKN HLHVCEGFTK NSPLSDPGKT DAKQTPCKGE 

       250        260        270        280        290        300 
RPHPCRVCGE GFSHGAVLPV HQVDPGEKCS HLQTHQRIHP GGTVNKCPKS GDGFHQNSFH 

       310        320        330        340        350        360 
PHHSNPTGEK SYRCDSCGKA FGSSTGLIIH YRTHTGEKPY RCEACGKCFS QSSNFQCHQR 

       370        380        390        400        410        420 
VHTEEKPYKC EECGKGFGWS VNLRVHQRVH RGEKPYKCEE CGKGFTQAAH YHIHQRVHTG 

       430        440        450        460        470        480 
EKPYKCDVCG KGFSHNSPLI CHRRVHTGEK PYRCEACGKG FTRNTDLHIH FRVHTGEKPY 

       490        500        510        520        530        540 
TCKECGKGFS QASNLQVHQN VHTGEKRFKC ETCGKGFSQS SKLQTHQRVH TGEKPYRCDV 

       550        560        570        580        590        600 
CGKDFSYSSN LKLHQVIHTG EKPYTCEACG KGFSWRSNLH AHQRVHSGEK PYKCEACDKS 

       610        620        630        640        650        660 
FSQAIDFRVH QRVHTGEKPY KCGVCGKGFS QSSGLQSHQR VHTGEKPYKC DVCGKGFRYS 

       670        680        690        700        710        720 
SQFIYHQRGH TGEKPYKCEE CGKGFGRSLN LRHHQRVHTG EKPHKCEECG KAFSLPSNLR 

       730        740        750        760        770        780 
VHLSVHTREK LFKCEDCGKG FSQSSRLQAH QRVHTGEKPY KCNICGKDFS HRSRLTYHQK 


VHTGKNL

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal cerebellum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC126592 mRNA. Translation: AAI26593.1.
IPIIPI00826796.
RefSeqNP_001071428.1. NM_001077960.1.
UniGeneBt.62016.

3D structure databases

ProteinModelPortalA0JNB1.
SMRA0JNB1. Positions 310-785.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000017798.

Proteomic databases

PRIDEA0JNB1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000017798; ENSBTAP00000017798; ENSBTAG00000027431.
GeneID524111.
KEGGbta:524111.

Organism-specific databases

CTD7770.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00550000074243.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidA0JNB1.
KOK09228.
OMARLTYHQK.
OrthoDBEOG42V8FN.

Family and domain databases

Gene3D3.30.160.60. 18 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMSSF109640. Krueppel-associated_box. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20873891.

Entry information

Entry nameZN227_BOVIN
AccessionPrimary (citable) accession number: A0JNB1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 12, 2006
Last modified: April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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