A0JN76 (ZBT18_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 18

Alternative name(s):
Zinc finger protein 238

Gene names

Name:	ZBTB18
Synonyms:	ZNF238

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus By similarity.
Subunit structure	Interacts with DNMT3A By similarity.
Subcellular location	Nucleus By similarity. Note: Associates with condensed chromatin By similarity.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily. Contains 1 BTB (POZ) domain. Contains 4 C2H2-type zinc fingers.
Sequence caution	The sequence AAI26551.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cerebellum development Inferred from electronic annotation. Source: Compara cerebral cortex development Inferred from electronic annotation. Source: Compara hippocampus development Inferred from electronic annotation. Source: Compara homeostasis of number of cells Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB neuron development Inferred from electronic annotation. Source: Compara regulation of cell division Inferred from electronic annotation. Source: Compara skeletal muscle tissue development Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 522	522	Zinc finger and BTB domain-containing protein 18		PRO_0000391924
Regions
	Domain	24 – 91	68	BTB
	Zinc finger	370 – 392	23	C2H2-type 1
	Zinc finger	410 – 432	23	C2H2-type 2
	Zinc finger	438 – 460	23	C2H2-type 3
	Zinc finger	466 – 489	24	C2H2-type 4
	Region	310 – 427	118	Interaction with DNMT3A By similarity
Amino acid modifications
	Modified residue	516	1	Phosphoserine By similarity
	Modified residue	517	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0JN76 [UniParc]. Last modified March 2, 2010. Version 2. Checksum: 1483EE21ACEAE14C	FASTA	522	58,356
	10 20 30 40 50 60 MEFPDHSRHL LQCLSEQRHQ GFLCDCTVLV GDAQFRAHRA VLASCSMYFH LFYKDQLDKR 70 80 90 100 110 120 DIVHLNSDIV TAPAFALLLE FMYEGKLQFK DLPIEDVLAA ASYLHMYDIV KVCKKKLKEK 130 140 150 160 170 180 ATTEADSTKK EEDASSCSDK VESLSDGSSH MAGDLPSDED EGEDEKLNIL PSKRDLAAEP 190 200 210 220 230 240 GNMWMRLPSD SAGIPQAGGE AEPHATAAGK TVASPCSSTE SLSQRSVTSV RDSADVDCVL 250 260 270 280 290 300 DLSVKSSLSG VENLNSSYFS SQDVLRSNLV QVKVEKEASC DESDVGTNDY DMEHSTVKES 310 320 330 340 350 360 VSTNNRVQYE PAHLAPLRED SVLRELERED KASDDEMMTP ESERVQVEGG MESSLLPYVS 370 380 390 400 410 420 NILSPAGQIF MCPLCNKVFP SPHILQIHLS THFREQDGLR SKPAADVNVP TCSLCGKTFS 430 440 450 460 470 480 CMYTLKRHER THSGEKPYTC TQCGKSFQYS HNLSRHAVVH TREKPHACKW CERRFTQSGD 490 500 510 520 LYRHIRKFHC ELVNSLSVKS EALSLPAVRD WTLEDSSQEL WK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal cerebellum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC126550 mRNA. Translation: AAI26551.1. Different initiation.
IPI	IPI00824921.
RefSeq	NP_001071484.1. NM_001078016.1.
UniGene	Bt.15860.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000000497; ENSBTAP00000000497; ENSBTAG00000000385.
GeneID	538793.
KEGG	bta:538793.
Organism-specific databases
CTD	428580.
Phylogenomic databases
eggNOG	COG5048.
GeneTree	ENSGT00680000099682.
HOGENOM	HOG000234147.
HOVERGEN	HBG059113.
InParanoid	A0JN76.
OrthoDB	EOG47SSDG.
Family and domain databases
Gene3D	3.30.160.60. 3 hits. 3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 4 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	20877584.

Entry information

Entry name

ZBT18_BOVIN

Accession

Primary (citable) accession number: A0JN76

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 2, 2010
Last sequence update:	March 2, 2010
Last modified:	May 1, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program