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A0JN76

- ZBT18_BOVIN

UniProt

A0JN76 - ZBT18_BOVIN

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Protein

Zinc finger and BTB domain-containing protein 18

Gene

ZBTB18

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri370 – 39223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48924C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  1. cerebellum development Source: Ensembl
  2. cerebral cortex development Source: Ensembl
  3. hippocampus development Source: Ensembl
  4. homeostasis of number of cells Source: Ensembl
  5. in utero embryonic development Source: Ensembl
  6. negative regulation of transcription, DNA-templated Source: UniProtKB
  7. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  8. neuron development Source: Ensembl
  9. regulation of cell division Source: Ensembl
  10. skeletal muscle tissue development Source: UniProtKB
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 18
Alternative name(s):
Zinc finger protein 238
Gene namesi
Name:ZBTB18
Synonyms:ZNF238
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 16

Subcellular locationi

Nucleus By similarity
Note: Associates with condensed chromatin.By similarity

GO - Cellular componenti

  1. intercellular bridge Source: Ensembl
  2. microtubule cytoskeleton Source: Ensembl
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Zinc finger and BTB domain-containing protein 18PRO_0000391924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei516 – 5161PhosphoserineBy similarity
Modified residuei517 – 5171PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with DNMT3A.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000497.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9168BTBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni310 – 427118Interaction with DNMT3ABy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri370 – 39223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri410 – 43223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48924C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118922.
HOGENOMiHOG000234147.
HOVERGENiHBG059113.
InParanoidiA0JN76.
OrthoDBiEOG73FQM8.
TreeFamiTF337437.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JN76-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFPDHSRHL LQCLSEQRHQ GFLCDCTVLV GDAQFRAHRA VLASCSMYFH
60 70 80 90 100
LFYKDQLDKR DIVHLNSDIV TAPAFALLLE FMYEGKLQFK DLPIEDVLAA
110 120 130 140 150
ASYLHMYDIV KVCKKKLKEK ATTEADSTKK EEDASSCSDK VESLSDGSSH
160 170 180 190 200
MAGDLPSDED EGEDEKLNIL PSKRDLAAEP GNMWMRLPSD SAGIPQAGGE
210 220 230 240 250
AEPHATAAGK TVASPCSSTE SLSQRSVTSV RDSADVDCVL DLSVKSSLSG
260 270 280 290 300
VENLNSSYFS SQDVLRSNLV QVKVEKEASC DESDVGTNDY DMEHSTVKES
310 320 330 340 350
VSTNNRVQYE PAHLAPLRED SVLRELERED KASDDEMMTP ESERVQVEGG
360 370 380 390 400
MESSLLPYVS NILSPAGQIF MCPLCNKVFP SPHILQIHLS THFREQDGLR
410 420 430 440 450
SKPAADVNVP TCSLCGKTFS CMYTLKRHER THSGEKPYTC TQCGKSFQYS
460 470 480 490 500
HNLSRHAVVH TREKPHACKW CERRFTQSGD LYRHIRKFHC ELVNSLSVKS
510 520
EALSLPAVRD WTLEDSSQEL WK
Length:522
Mass (Da):58,356
Last modified:March 2, 2010 - v2
Checksum:i1483EE21ACEAE14C
GO

Sequence cautioni

The sequence AAI26551.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126550 mRNA. Translation: AAI26551.1. Different initiation.
RefSeqiNP_001071484.1. NM_001078016.1.
UniGeneiBt.15860.

Genome annotation databases

EnsembliENSBTAT00000000497; ENSBTAP00000000497; ENSBTAG00000000385.
GeneIDi538793.
KEGGibta:538793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126550 mRNA. Translation: AAI26551.1 . Different initiation.
RefSeqi NP_001071484.1. NM_001078016.1.
UniGenei Bt.15860.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000000497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000000497 ; ENSBTAP00000000497 ; ENSBTAG00000000385 .
GeneIDi 538793.
KEGGi bta:538793.

Organism-specific databases

CTDi 10472.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118922.
HOGENOMi HOG000234147.
HOVERGENi HBG059113.
InParanoidi A0JN76.
OrthoDBi EOG73FQM8.
TreeFami TF337437.

Miscellaneous databases

NextBioi 20877584.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiZBT18_BOVIN
AccessioniPrimary (citable) accession number: A0JN76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: October 29, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3