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A0JN76 (ZBT18_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and BTB domain-containing protein 18
Alternative name(s):
Zinc finger protein 238
Gene names
Name:ZBTB18
Synonyms:ZNF238
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus By similarity.

Subunit structure

Interacts with DNMT3A By similarity.

Subcellular location

Nucleus By similarity. Note: Associates with condensed chromatin By similarity.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.

Contains 1 BTB (POZ) domain.

Contains 4 C2H2-type zinc fingers.

Sequence caution

The sequence AAI26551.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionDevelopmental protein
Repressor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcerebellum development

Inferred from electronic annotation. Source: Ensembl

cerebral cortex development

Inferred from electronic annotation. Source: Ensembl

hippocampus development

Inferred from electronic annotation. Source: Ensembl

homeostasis of number of cells

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

neuron development

Inferred from electronic annotation. Source: Ensembl

regulation of cell division

Inferred from electronic annotation. Source: Ensembl

skeletal muscle tissue development

Inferred from sequence or structural similarity. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Zinc finger and BTB domain-containing protein 18
PRO_0000391924

Regions

Domain24 – 9168BTB
Zinc finger370 – 39223C2H2-type 1
Zinc finger410 – 43223C2H2-type 2
Zinc finger438 – 46023C2H2-type 3
Zinc finger466 – 48924C2H2-type 4
Region310 – 427118Interaction with DNMT3A By similarity

Amino acid modifications

Modified residue5161Phosphoserine By similarity
Modified residue5171Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A0JN76 [UniParc].

Last modified March 2, 2010. Version 2.
Checksum: 1483EE21ACEAE14C

FASTA52258,356
        10         20         30         40         50         60 
MEFPDHSRHL LQCLSEQRHQ GFLCDCTVLV GDAQFRAHRA VLASCSMYFH LFYKDQLDKR 

        70         80         90        100        110        120 
DIVHLNSDIV TAPAFALLLE FMYEGKLQFK DLPIEDVLAA ASYLHMYDIV KVCKKKLKEK 

       130        140        150        160        170        180 
ATTEADSTKK EEDASSCSDK VESLSDGSSH MAGDLPSDED EGEDEKLNIL PSKRDLAAEP 

       190        200        210        220        230        240 
GNMWMRLPSD SAGIPQAGGE AEPHATAAGK TVASPCSSTE SLSQRSVTSV RDSADVDCVL 

       250        260        270        280        290        300 
DLSVKSSLSG VENLNSSYFS SQDVLRSNLV QVKVEKEASC DESDVGTNDY DMEHSTVKES 

       310        320        330        340        350        360 
VSTNNRVQYE PAHLAPLRED SVLRELERED KASDDEMMTP ESERVQVEGG MESSLLPYVS 

       370        380        390        400        410        420 
NILSPAGQIF MCPLCNKVFP SPHILQIHLS THFREQDGLR SKPAADVNVP TCSLCGKTFS 

       430        440        450        460        470        480 
CMYTLKRHER THSGEKPYTC TQCGKSFQYS HNLSRHAVVH TREKPHACKW CERRFTQSGD 

       490        500        510        520 
LYRHIRKFHC ELVNSLSVKS EALSLPAVRD WTLEDSSQEL WK 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal cerebellum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC126550 mRNA. Translation: AAI26551.1. Different initiation.
RefSeqNP_001071484.1. NM_001078016.1.
UniGeneBt.15860.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000000497.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000000497; ENSBTAP00000000497; ENSBTAG00000000385.
GeneID538793.
KEGGbta:538793.

Organism-specific databases

CTD10472.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117353.
HOGENOMHOG000234147.
HOVERGENHBG059113.
InParanoidA0JN76.
OrthoDBEOG73FQM8.
TreeFamTF337437.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20877584.

Entry information

Entry nameZBT18_BOVIN
AccessionPrimary (citable) accession number: A0JN76
Entry history
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: April 16, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families