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A0JN76

- ZBT18_BOVIN

UniProt

A0JN76 - ZBT18_BOVIN

Protein

Zinc finger and BTB domain-containing protein 18

Gene

ZBTB18

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May also play a role in the organization of chromosomes in the nucleus By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri370 – 39223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri410 – 43223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 46023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri466 – 48924C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. cerebellum development Source: Ensembl
    2. cerebral cortex development Source: Ensembl
    3. hippocampus development Source: Ensembl
    4. homeostasis of number of cells Source: Ensembl
    5. in utero embryonic development Source: Ensembl
    6. negative regulation of transcription, DNA-templated Source: UniProtKB
    7. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    8. neuron development Source: Ensembl
    9. regulation of cell division Source: Ensembl
    10. skeletal muscle tissue development Source: UniProtKB
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 18
    Alternative name(s):
    Zinc finger protein 238
    Gene namesi
    Name:ZBTB18
    Synonyms:ZNF238
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 16

    Subcellular locationi

    Nucleus By similarity
    Note: Associates with condensed chromatin.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Zinc finger and BTB domain-containing protein 18PRO_0000391924Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei516 – 5161PhosphoserineBy similarity
    Modified residuei517 – 5171PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with DNMT3A.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000000497.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 9168BTBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni310 – 427118Interaction with DNMT3ABy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri370 – 39223C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri410 – 43223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 46023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri466 – 48924C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117353.
    HOGENOMiHOG000234147.
    HOVERGENiHBG059113.
    InParanoidiA0JN76.
    OrthoDBiEOG73FQM8.
    TreeFamiTF337437.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JN76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFPDHSRHL LQCLSEQRHQ GFLCDCTVLV GDAQFRAHRA VLASCSMYFH    50
    LFYKDQLDKR DIVHLNSDIV TAPAFALLLE FMYEGKLQFK DLPIEDVLAA 100
    ASYLHMYDIV KVCKKKLKEK ATTEADSTKK EEDASSCSDK VESLSDGSSH 150
    MAGDLPSDED EGEDEKLNIL PSKRDLAAEP GNMWMRLPSD SAGIPQAGGE 200
    AEPHATAAGK TVASPCSSTE SLSQRSVTSV RDSADVDCVL DLSVKSSLSG 250
    VENLNSSYFS SQDVLRSNLV QVKVEKEASC DESDVGTNDY DMEHSTVKES 300
    VSTNNRVQYE PAHLAPLRED SVLRELERED KASDDEMMTP ESERVQVEGG 350
    MESSLLPYVS NILSPAGQIF MCPLCNKVFP SPHILQIHLS THFREQDGLR 400
    SKPAADVNVP TCSLCGKTFS CMYTLKRHER THSGEKPYTC TQCGKSFQYS 450
    HNLSRHAVVH TREKPHACKW CERRFTQSGD LYRHIRKFHC ELVNSLSVKS 500
    EALSLPAVRD WTLEDSSQEL WK 522
    Length:522
    Mass (Da):58,356
    Last modified:March 2, 2010 - v2
    Checksum:i1483EE21ACEAE14C
    GO

    Sequence cautioni

    The sequence AAI26551.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126550 mRNA. Translation: AAI26551.1. Different initiation.
    RefSeqiNP_001071484.1. NM_001078016.1.
    UniGeneiBt.15860.

    Genome annotation databases

    EnsembliENSBTAT00000000497; ENSBTAP00000000497; ENSBTAG00000000385.
    GeneIDi538793.
    KEGGibta:538793.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126550 mRNA. Translation: AAI26551.1 . Different initiation.
    RefSeqi NP_001071484.1. NM_001078016.1.
    UniGenei Bt.15860.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000000497.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000000497 ; ENSBTAP00000000497 ; ENSBTAG00000000385 .
    GeneIDi 538793.
    KEGGi bta:538793.

    Organism-specific databases

    CTDi 10472.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117353.
    HOGENOMi HOG000234147.
    HOVERGENi HBG059113.
    InParanoidi A0JN76.
    OrthoDBi EOG73FQM8.
    TreeFami TF337437.

    Miscellaneous databases

    NextBioi 20877584.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal cerebellum.

    Entry informationi

    Entry nameiZBT18_BOVIN
    AccessioniPrimary (citable) accession number: A0JN76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 2, 2010
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3