ID SASH3_BOVIN Reviewed; 380 AA. AC A0JN71; DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot. DT 29-APR-2008, sequence version 2. DT 24-JAN-2024, entry version 97. DE RecName: Full=SAM and SH3 domain-containing protein 3; GN Name=SASH3 {ECO:0000250|UniProtKB:Q8K352}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford; RX PubMed=19390049; DOI=10.1126/science.1169588; RG The bovine genome sequencing and analysis consortium; RT "The genome sequence of taurine cattle: a window to ruminant biology and RT evolution."; RL Science 324:522-528(2009). RN [2] {ECO:0000305, ECO:0000312|EMBL:AAI26546.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Hereford {ECO:0000312|EMBL:AAI26546.1}; RC TISSUE=Thymus {ECO:0000312|EMBL:AAI26546.1}; RG NIH - Mammalian Gene Collection (MGC) project; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May function as a signaling adapter protein in lymphocytes. CC {ECO:0000250|UniProtKB:Q8K352}. CC -!- SIMILARITY: Belongs to the SASH family. {ECO:0000255}. CC -!- SEQUENCE CAUTION: CC Sequence=AAI26546.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAFC03003066; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC126545; AAI26546.1; ALT_SEQ; mRNA. DR RefSeq; NP_001071466.1; NM_001077998.2. DR RefSeq; XP_010819700.1; XM_010821398.2. DR AlphaFoldDB; A0JN71; -. DR SMR; A0JN71; -. DR STRING; 9913.ENSBTAP00000002645; -. DR PaxDb; 9913-ENSBTAP00000002645; -. DR Ensembl; ENSBTAT00000002645.5; ENSBTAP00000002645.4; ENSBTAG00000002041.5. DR GeneID; 534137; -. DR KEGG; bta:534137; -. DR CTD; 54440; -. DR VEuPathDB; HostDB:ENSBTAG00000002041; -. DR VGNC; VGNC:34294; SASH3. DR eggNOG; KOG4384; Eukaryota. DR GeneTree; ENSGT00940000160111; -. DR HOGENOM; CLU_027875_0_0_1; -. DR InParanoid; A0JN71; -. DR OMA; EDSAYNG; -. DR OrthoDB; 5403637at2759; -. DR TreeFam; TF350709; -. DR Proteomes; UP000009136; Chromosome X. DR Bgee; ENSBTAG00000002041; Expressed in thymus and 99 other cell types or tissues. DR ExpressionAtlas; A0JN71; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl. DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl. DR GO; GO:0043367; P:CD4-positive, alpha-beta T cell differentiation; IEA:Ensembl. DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl. DR GO; GO:0002821; P:positive regulation of adaptive immune response; IBA:GO_Central. DR GO; GO:0030890; P:positive regulation of B cell proliferation; IBA:GO_Central. DR GO; GO:0043372; P:positive regulation of CD4-positive, alpha-beta T cell differentiation; IEA:Ensembl. DR GO; GO:0002639; P:positive regulation of immunoglobulin production; IBA:GO_Central. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl. DR GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl. DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl. DR GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl. DR GO; GO:0002726; P:positive regulation of T cell cytokine production; IEA:Ensembl. DR GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl. DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl. DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl. DR GO; GO:0042098; P:T cell proliferation; IEA:Ensembl. DR CDD; cd11968; SH3_SASH3; 1. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1. DR InterPro; IPR001660; SAM. DR InterPro; IPR013761; SAM/pointed_sf. DR InterPro; IPR035721; SASH3_SH3. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR InterPro; IPR021090; SPIDER. DR PANTHER; PTHR12301:SF5; SAM AND SH3 DOMAIN-CONTAINING PROTEIN 3; 1. DR PANTHER; PTHR12301; SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED; 1. DR Pfam; PF00536; SAM_1; 1. DR Pfam; PF07653; SH3_2; 1. DR Pfam; PF12485; SLY; 1. DR SMART; SM00454; SAM; 1. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF47769; SAM/Pointed domain; 1. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS50105; SAM_DOMAIN; 1. DR PROSITE; PS50002; SH3; 1. PE 2: Evidence at transcript level; KW Phosphoprotein; Reference proteome; SH3 domain. FT CHAIN 1..380 FT /note="SAM and SH3 domain-containing protein 3" FT /id="PRO_0000331222" FT DOMAIN 173..234 FT /note="SH3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192" FT DOMAIN 252..316 FT /note="SAM" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184" FT REGION 1..174 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 318..380 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..19 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 140..167 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 346..367 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 27 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 34 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 42 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 61 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 97 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 103 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 110 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 112 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 113 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 120 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 318 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT MOD_RES 320 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O75995" FT CONFLICT 318 FT /note="T -> S (in Ref. 1; AAFC03003066)" FT /evidence="ECO:0000305" SQ SEQUENCE 380 AA; 41566 MW; 7CD75BE4EDFB7352 CRC64; MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD NIPEDESSVP TPEDAEKSGK KLGKKWRAVI SRTMNRKTGK KMVKALSEEM GDTLEEGSAS PTSPDCSLDS PGPEKMALAF SEQEERELPA LSRQASTGSE LCSPSPGSGN LGEESTAPQY TGPFCGRARV HTDFTPSPYD RDSLKLQKGD VIQIVEKPPV GTWLGLLNGR MGSFKFIYVD VLPEEAVGPA RPSRRQSKGK RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP QHRAKLLTAA ELLLDYDTGS EEAEEGTESG QEPAVSTVAD PKVDIPRDSG CFEGSESGRD EAELAGTEEQ LHGLSLSGAP //