Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A0JN71 (SASH3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SAM and SH3 domain-containing protein 3
Gene names
Name:SASH3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May function as a signaling adapter protein in lymphocytes By similarity. UniProtKB Q8K352

Sequence similarities

Belongs to the SASH family.

Contains 1 SAM (sterile alpha motif) domain.

Contains 1 SH3 domain.

Sequence caution

The sequence AAI26546.1 differs from that shown. Reason: Erroneous termination at position 282. Translated as Glu.

Ontologies

Keywords
   DomainSH3 domain
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhomeostasis of number of cells within a tissue

Inferred from electronic annotation. Source: Ensembl

positive regulation of B cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of CD4-positive, alpha-beta T cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell cytokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of immunoglobulin production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-10 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-2 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-4 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of organ growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380SAM and SH3 domain-containing protein 3
PRO_0000331222

Regions

Domain173 – 23462SH3
Domain252 – 31665SAM

Amino acid modifications

Modified residue271Phosphoserine By similarity
Modified residue341Phosphoserine By similarity
Modified residue421Phosphoserine By similarity
Modified residue611Phosphothreonine By similarity
Modified residue971Phosphoserine By similarity
Modified residue1031Phosphothreonine By similarity
Modified residue1101Phosphoserine By similarity
Modified residue1121Phosphothreonine By similarity
Modified residue1131Phosphoserine By similarity
Modified residue1201Phosphoserine By similarity
Modified residue3181Phosphothreonine By similarity
Modified residue3201Phosphoserine By similarity

Experimental info

Sequence conflict3181T → S in AAFC03003066. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A0JN71 [UniParc].

Last modified April 29, 2008. Version 2.
Checksum: 7CD75BE4EDFB7352

FASTA38041,566
        10         20         30         40         50         60 
MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD NIPEDESSVP 

        70         80         90        100        110        120 
TPEDAEKSGK KLGKKWRAVI SRTMNRKTGK KMVKALSEEM GDTLEEGSAS PTSPDCSLDS 

       130        140        150        160        170        180 
PGPEKMALAF SEQEERELPA LSRQASTGSE LCSPSPGSGN LGEESTAPQY TGPFCGRARV 

       190        200        210        220        230        240 
HTDFTPSPYD RDSLKLQKGD VIQIVEKPPV GTWLGLLNGR MGSFKFIYVD VLPEEAVGPA 

       250        260        270        280        290        300 
RPSRRQSKGK RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP 

       310        320        330        340        350        360 
QHRAKLLTAA ELLLDYDTGS EEAEEGTESG QEPAVSTVAD PKVDIPRDSG CFEGSESGRD 

       370        380 
EAELAGTEEQ LHGLSLSGAP 

« Hide

References

[1]"The genome sequence of taurine cattle: a window to ruminant biology and evolution."
The bovine genome sequencing and analysis consortium
Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hereford.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFC03003066 Genomic DNA. No translation available.
BC126545 mRNA. Translation: AAI26546.1. Sequence problems.
RefSeqNP_001071466.1. NM_001077998.2.
XP_005227549.1. XM_005227492.1.
UniGeneBt.54950.

3D structure databases

ProteinModelPortalA0JN71.
SMRA0JN71. Positions 174-240, 247-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000002645.

Proteomic databases

PRIDEA0JN71.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000002645; ENSBTAP00000002645; ENSBTAG00000002041.
GeneID534137.
KEGGbta:534137.

Organism-specific databases

CTD54440.

Phylogenomic databases

eggNOGNOG252868.
GeneTreeENSGT00390000014672.
HOGENOMHOG000049202.
HOVERGENHBG000461.
InParanoidA0JN71.
OMAEMGDTLE.
OrthoDBEOG7KQ20X.
TreeFamTF350709.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
InterProIPR021090. rSAM/SH3_domain-containing.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF07647. SAM_2. 1 hit.
PF07653. SH3_2. 1 hit.
PF12485. SLY. 1 hit.
[Graphical view]
SMARTSM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876284.

Entry information

Entry nameSASH3_BOVIN
AccessionPrimary (citable) accession number: A0JN71
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: March 19, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families