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Protein

SAM and SH3 domain-containing protein 3

Gene

SASH3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a signaling adapter protein in lymphocytes.By similarity

GO - Biological processi

  1. homeostasis of number of cells within a tissue Source: Ensembl
  2. positive regulation of B cell proliferation Source: Ensembl
  3. positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
  4. positive regulation of immunoglobulin production Source: Ensembl
  5. positive regulation of interferon-gamma production Source: Ensembl
  6. positive regulation of interleukin-10 production Source: Ensembl
  7. positive regulation of interleukin-2 production Source: Ensembl
  8. positive regulation of interleukin-4 production Source: Ensembl
  9. positive regulation of organ growth Source: Ensembl
  10. positive regulation of T cell cytokine production Source: Ensembl
  11. positive regulation of T cell proliferation Source: Ensembl
  12. positive regulation of tumor necrosis factor production Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SAM and SH3 domain-containing protein 3
Gene namesi
Name:SASH3By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome X

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380SAM and SH3 domain-containing protein 3PRO_0000331222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei34 – 341PhosphoserineBy similarity
Modified residuei42 – 421PhosphoserineBy similarity
Modified residuei61 – 611PhosphothreonineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei103 – 1031PhosphothreonineBy similarity
Modified residuei110 – 1101PhosphoserineBy similarity
Modified residuei112 – 1121PhosphothreonineBy similarity
Modified residuei113 – 1131PhosphoserineBy similarity
Modified residuei120 – 1201PhosphoserineBy similarity
Modified residuei318 – 3181PhosphothreonineBy similarity
Modified residuei320 – 3201PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA0JN71.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002645.

Structurei

3D structure databases

ProteinModelPortaliA0JN71.
SMRiA0JN71. Positions 174-240, 247-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 23462SH3Sequence AnalysisAdd
BLAST
Domaini252 – 31665SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SASH family.Sequence Analysis
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.Sequence Analysis

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG252868.
GeneTreeiENSGT00390000014672.
HOGENOMiHOG000049202.
HOVERGENiHBG000461.
InParanoidiA0JN71.
OMAiEMGDTLE.
OrthoDBiEOG7KQ20X.
TreeFamiTF350709.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021090. rSAM/SH3_domain-containing.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
PF07653. SH3_2. 1 hit.
PF12485. SLY. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JN71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD
60 70 80 90 100
NIPEDESSVP TPEDAEKSGK KLGKKWRAVI SRTMNRKTGK KMVKALSEEM
110 120 130 140 150
GDTLEEGSAS PTSPDCSLDS PGPEKMALAF SEQEERELPA LSRQASTGSE
160 170 180 190 200
LCSPSPGSGN LGEESTAPQY TGPFCGRARV HTDFTPSPYD RDSLKLQKGD
210 220 230 240 250
VIQIVEKPPV GTWLGLLNGR MGSFKFIYVD VLPEEAVGPA RPSRRQSKGK
260 270 280 290 300
RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP
310 320 330 340 350
QHRAKLLTAA ELLLDYDTGS EEAEEGTESG QEPAVSTVAD PKVDIPRDSG
360 370 380
CFEGSESGRD EAELAGTEEQ LHGLSLSGAP
Length:380
Mass (Da):41,566
Last modified:April 28, 2008 - v2
Checksum:i7CD75BE4EDFB7352
GO

Sequence cautioni

The sequence AAI26546.1 differs from that shown. Reason: Erroneous termination at position 282. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti318 – 3181T → S in AAFC03003066 (PubMed:19390049).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03003066 Genomic DNA. No translation available.
BC126545 mRNA. Translation: AAI26546.1. Sequence problems.
RefSeqiNP_001071466.1. NM_001077998.2.
XP_010819700.1. XM_010821398.1.
UniGeneiBt.54950.

Genome annotation databases

EnsembliENSBTAT00000002645; ENSBTAP00000002645; ENSBTAG00000002041.
GeneIDi534137.
KEGGibta:534137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03003066 Genomic DNA. No translation available.
BC126545 mRNA. Translation: AAI26546.1. Sequence problems.
RefSeqiNP_001071466.1. NM_001077998.2.
XP_010819700.1. XM_010821398.1.
UniGeneiBt.54950.

3D structure databases

ProteinModelPortaliA0JN71.
SMRiA0JN71. Positions 174-240, 247-314.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002645.

Proteomic databases

PRIDEiA0JN71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002645; ENSBTAP00000002645; ENSBTAG00000002041.
GeneIDi534137.
KEGGibta:534137.

Organism-specific databases

CTDi54440.

Phylogenomic databases

eggNOGiNOG252868.
GeneTreeiENSGT00390000014672.
HOGENOMiHOG000049202.
HOVERGENiHBG000461.
InParanoidiA0JN71.
OMAiEMGDTLE.
OrthoDBiEOG7KQ20X.
TreeFamiTF350709.

Miscellaneous databases

NextBioi20876284.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR021090. rSAM/SH3_domain-containing.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
PF07653. SH3_2. 1 hit.
PF12485. SLY. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: HerefordImported.
    Tissue: ThymusImported.

Entry informationi

Entry nameiSASH3_BOVIN
AccessioniPrimary (citable) accession number: A0JN71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 28, 2008
Last sequence update: April 28, 2008
Last modified: March 3, 2015
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.