A0JN71 (SASH3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SAM and SH3 domain-containing protein 3

Gene names

Name:

SASH3

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as a signaling adapter protein in lymphocytes By similarity. UniProtKB Q8K352
Sequence similarities	Belongs to the SASH family. Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain.
Sequence caution	The sequence AAI26546.1 differs from that shown. Reason: Erroneous termination at position 282. Translated as Glu.

Ontologies

Keywords
Domain	SH3 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homeostasis of number of cells within a tissue Inferred from electronic annotation. Source: Compara positive regulation of B cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of CD4-positive, alpha-beta T cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of T cell cytokine production Inferred from electronic annotation. Source: Compara positive regulation of T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of immunoglobulin production Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-10 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-2 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-4 production Inferred from electronic annotation. Source: Compara positive regulation of organ growth Inferred from electronic annotation. Source: Compara positive regulation of tumor necrosis factor production Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	SAM and SH3 domain-containing protein 3		PRO_0000331222
Regions
	Domain	173 – 234	62	SH3
	Domain	252 – 316	65	SAM
Amino acid modifications
	Modified residue	27	1	Phosphoserine By similarity
	Modified residue	34	1	Phosphoserine By similarity
	Modified residue	42	1	Phosphoserine By similarity
	Modified residue	61	1	Phosphothreonine By similarity
	Modified residue	97	1	Phosphoserine By similarity
	Modified residue	103	1	Phosphothreonine By similarity
	Modified residue	110	1	Phosphoserine By similarity
	Modified residue	112	1	Phosphothreonine By similarity
	Modified residue	113	1	Phosphoserine By similarity
	Modified residue	120	1	Phosphoserine By similarity
	Modified residue	318	1	Phosphothreonine By similarity
	Modified residue	320	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	318	1	T → S in AAFC03003066. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	A0JN71 [UniParc]. Last modified April 29, 2008. Version 2. Checksum: 7CD75BE4EDFB7352	FASTA	380	41,566
	10 20 30 40 50 60 MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD NIPEDESSVP 70 80 90 100 110 120 TPEDAEKSGK KLGKKWRAVI SRTMNRKTGK KMVKALSEEM GDTLEEGSAS PTSPDCSLDS 130 140 150 160 170 180 PGPEKMALAF SEQEERELPA LSRQASTGSE LCSPSPGSGN LGEESTAPQY TGPFCGRARV 190 200 210 220 230 240 HTDFTPSPYD RDSLKLQKGD VIQIVEKPPV GTWLGLLNGR MGSFKFIYVD VLPEEAVGPA 250 260 270 280 290 300 RPSRRQSKGK RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP 310 320 330 340 350 360 QHRAKLLTAA ELLLDYDTGS EEAEEGTESG QEPAVSTVAD PKVDIPRDSG CFEGSESGRD 370 380 EAELAGTEEQ LHGLSLSGAP

References

[1]	"The genome sequence of taurine cattle: a window to ruminant biology and evolution." The bovine genome sequencing and analysis consortium Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Hereford.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFC03003066 Genomic DNA. No translation available. BC126545 mRNA. Translation: AAI26546.1. Sequence problems.
IPI	IPI00824771.
RefSeq	NP_001071466.1. NM_001077998.2.
UniGene	Bt.54950.
3D structure databases
ProteinModelPortal	A0JN71.
SMR	A0JN71. Positions 174-240, 247-314.
ModBase	Search...
Proteomic databases
PRIDE	A0JN71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000002645; ENSBTAP00000002645; ENSBTAG00000002041.
GeneID	534137.
KEGG	bta:534137.
Organism-specific databases
CTD	54440.
Phylogenomic databases
eggNOG	NOG252868.
GeneTree	ENSGT00390000014672.
HOGENOM	HOG000049202.
HOVERGEN	HBG000461.
InParanoid	A0JN71.
OMA	NRKMGKM.
OrthoDB	EOG441QBR.
Family and domain databases
Gene3D	1.10.150.50. 1 hit.
InterPro	IPR021090. rSAM/SH3_domain-containing. IPR001660. SAM. IPR013761. SAM/pointed. IPR011510. SAM_2. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF07647. SAM_2. 1 hit. PF07653. SH3_2. 1 hit. PF12485. SLY. 1 hit. [Graphical view]
SMART	SM00454. SAM. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF47769. SAM_homology. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS50105. SAM_DOMAIN. 1 hit. PS50002. SH3. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20876284.

Entry information

Entry name

SASH3_BOVIN

Accession

Primary (citable) accession number: A0JN71

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	March 6, 2013
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program