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A0JN71

- SASH3_BOVIN

UniProt

A0JN71 - SASH3_BOVIN

Protein

SAM and SH3 domain-containing protein 3

Gene

SASH3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 2 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    May function as a signaling adapter protein in lymphocytes.By similarity

    GO - Biological processi

    1. homeostasis of number of cells within a tissue Source: Ensembl
    2. positive regulation of B cell proliferation Source: Ensembl
    3. positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
    4. positive regulation of immunoglobulin production Source: Ensembl
    5. positive regulation of interferon-gamma production Source: Ensembl
    6. positive regulation of interleukin-10 production Source: Ensembl
    7. positive regulation of interleukin-2 production Source: Ensembl
    8. positive regulation of interleukin-4 production Source: Ensembl
    9. positive regulation of organ growth Source: Ensembl
    10. positive regulation of T cell cytokine production Source: Ensembl
    11. positive regulation of T cell proliferation Source: Ensembl
    12. positive regulation of tumor necrosis factor production Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SAM and SH3 domain-containing protein 3
    Gene namesi
    Name:SASH3By similarity
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome X

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380SAM and SH3 domain-containing protein 3PRO_0000331222Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271PhosphoserineBy similarity
    Modified residuei34 – 341PhosphoserineBy similarity
    Modified residuei42 – 421PhosphoserineBy similarity
    Modified residuei61 – 611PhosphothreonineBy similarity
    Modified residuei97 – 971PhosphoserineBy similarity
    Modified residuei103 – 1031PhosphothreonineBy similarity
    Modified residuei110 – 1101PhosphoserineBy similarity
    Modified residuei112 – 1121PhosphothreonineBy similarity
    Modified residuei113 – 1131PhosphoserineBy similarity
    Modified residuei120 – 1201PhosphoserineBy similarity
    Modified residuei318 – 3181PhosphothreonineBy similarity
    Modified residuei320 – 3201PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiA0JN71.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000002645.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JN71.
    SMRiA0JN71. Positions 174-240, 247-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini173 – 23462SH3Sequence AnalysisAdd
    BLAST
    Domaini252 – 31665SAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SASH family.Sequence Analysis
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.Sequence Analysis

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG252868.
    GeneTreeiENSGT00390000014672.
    HOGENOMiHOG000049202.
    HOVERGENiHBG000461.
    InParanoidiA0JN71.
    OMAiEMGDTLE.
    OrthoDBiEOG7KQ20X.
    TreeFamiTF350709.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    InterProiIPR021090. rSAM/SH3_domain-containing.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF07647. SAM_2. 1 hit.
    PF07653. SH3_2. 1 hit.
    PF12485. SLY. 1 hit.
    [Graphical view]
    SMARTiSM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JN71-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD    50
    NIPEDESSVP TPEDAEKSGK KLGKKWRAVI SRTMNRKTGK KMVKALSEEM 100
    GDTLEEGSAS PTSPDCSLDS PGPEKMALAF SEQEERELPA LSRQASTGSE 150
    LCSPSPGSGN LGEESTAPQY TGPFCGRARV HTDFTPSPYD RDSLKLQKGD 200
    VIQIVEKPPV GTWLGLLNGR MGSFKFIYVD VLPEEAVGPA RPSRRQSKGK 250
    RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP 300
    QHRAKLLTAA ELLLDYDTGS EEAEEGTESG QEPAVSTVAD PKVDIPRDSG 350
    CFEGSESGRD EAELAGTEEQ LHGLSLSGAP 380
    Length:380
    Mass (Da):41,566
    Last modified:April 29, 2008 - v2
    Checksum:i7CD75BE4EDFB7352
    GO

    Sequence cautioni

    The sequence AAI26546.1 differs from that shown. Reason: Erroneous termination at position 282. Translated as Glu.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti318 – 3181T → S in AAFC03003066. (PubMed:19390049)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03003066 Genomic DNA. No translation available.
    BC126545 mRNA. Translation: AAI26546.1. Sequence problems.
    RefSeqiNP_001071466.1. NM_001077998.2.
    XP_005227549.1. XM_005227492.1.
    UniGeneiBt.54950.

    Genome annotation databases

    EnsembliENSBTAT00000002645; ENSBTAP00000002645; ENSBTAG00000002041.
    GeneIDi534137.
    KEGGibta:534137.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03003066 Genomic DNA. No translation available.
    BC126545 mRNA. Translation: AAI26546.1 . Sequence problems.
    RefSeqi NP_001071466.1. NM_001077998.2.
    XP_005227549.1. XM_005227492.1.
    UniGenei Bt.54950.

    3D structure databases

    ProteinModelPortali A0JN71.
    SMRi A0JN71. Positions 174-240, 247-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000002645.

    Proteomic databases

    PRIDEi A0JN71.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000002645 ; ENSBTAP00000002645 ; ENSBTAG00000002041 .
    GeneIDi 534137.
    KEGGi bta:534137.

    Organism-specific databases

    CTDi 54440.

    Phylogenomic databases

    eggNOGi NOG252868.
    GeneTreei ENSGT00390000014672.
    HOGENOMi HOG000049202.
    HOVERGENi HBG000461.
    InParanoidi A0JN71.
    OMAi EMGDTLE.
    OrthoDBi EOG7KQ20X.
    TreeFami TF350709.

    Miscellaneous databases

    NextBioi 20876284.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    InterProi IPR021090. rSAM/SH3_domain-containing.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR011510. SAM_2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF07647. SAM_2. 1 hit.
    PF07653. SH3_2. 1 hit.
    PF12485. SLY. 1 hit.
    [Graphical view ]
    SMARTi SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
      The bovine genome sequencing and analysis consortium
      Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: HerefordImported.
      Tissue: ThymusImported.

    Entry informationi

    Entry nameiSASH3_BOVIN
    AccessioniPrimary (citable) accession number: A0JN71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 55 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3