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Protein

SAM and SH3 domain-containing protein 3

Gene

SASH3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a signaling adapter protein in lymphocytes.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SAM and SH3 domain-containing protein 3
Gene namesi
Name:SASH3By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:34294 SASH3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312221 – 380SAM and SH3 domain-containing protein 3Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei42PhosphoserineBy similarity1
Modified residuei61PhosphothreonineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei110PhosphoserineBy similarity1
Modified residuei112PhosphothreonineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei318PhosphothreonineBy similarity1
Modified residuei320PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA0JN71
PRIDEiA0JN71

Expressioni

Gene expression databases

BgeeiENSBTAG00000002041

Structurei

3D structure databases

ProteinModelPortaliA0JN71
SMRiA0JN71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 234SH3PROSITE-ProRule annotationAdd BLAST62
Domaini252 – 316SAMPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the SASH family.Sequence analysis

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410INAS Eukaryota
ENOG410YC4U LUCA
GeneTreeiENSGT00390000014672
HOGENOMiHOG000049202
HOVERGENiHBG000461
InParanoidiA0JN71
OMAiEMGDTLE
OrthoDBiEOG091G0BS1
TreeFamiTF350709

Family and domain databases

CDDicd11968 SH3_SASH3, 1 hit
InterProiView protein in InterPro
IPR021090 rSAM/SH3_domain-containing
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR035722 SASH3
IPR035721 SASH3_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR12301:SF5 PTHR12301:SF5, 1 hit
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
PF07653 SH3_2, 1 hit
PF12485 SLY, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

A0JN71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRKPSNAS EKEPTQKKKL SLQRSSSFKD FAKSKPSSPV VSEKEFNLDD
60 70 80 90 100
NIPEDESSVP TPEDAEKSGK KLGKKWRAVI SRTMNRKTGK KMVKALSEEM
110 120 130 140 150
GDTLEEGSAS PTSPDCSLDS PGPEKMALAF SEQEERELPA LSRQASTGSE
160 170 180 190 200
LCSPSPGSGN LGEESTAPQY TGPFCGRARV HTDFTPSPYD RDSLKLQKGD
210 220 230 240 250
VIQIVEKPPV GTWLGLLNGR MGSFKFIYVD VLPEEAVGPA RPSRRQSKGK
260 270 280 290 300
RPKPKTLHEL LERIGLEEHT STLLLNGYQT LEDFKELRET HLNELNIMDP
310 320 330 340 350
QHRAKLLTAA ELLLDYDTGS EEAEEGTESG QEPAVSTVAD PKVDIPRDSG
360 370 380
CFEGSESGRD EAELAGTEEQ LHGLSLSGAP
Length:380
Mass (Da):41,566
Last modified:April 29, 2008 - v2
Checksum:i7CD75BE4EDFB7352
GO

Sequence cautioni

The sequence AAI26546 differs from that shown. Reason: Erroneous termination at position 282. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti318T → S in AAFC03003066 (PubMed:19390049).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03003066 Genomic DNA No translation available.
BC126545 mRNA Translation: AAI26546.1 Sequence problems.
RefSeqiNP_001071466.1, NM_001077998.2
XP_010819700.1, XM_010821398.2
UniGeneiBt.54950

Genome annotation databases

EnsembliENSBTAT00000002645; ENSBTAP00000002645; ENSBTAG00000002041
GeneIDi534137
KEGGibta:534137

Similar proteinsi

Entry informationi

Entry nameiSASH3_BOVIN
AccessioniPrimary (citable) accession number: A0JN71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: March 28, 2018
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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