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A0JN27

- TF2H2_RAT

UniProt

A0JN27 - TF2H2_RAT

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Protein

General transcription factor IIH subunit 2

Gene
Gtf2h2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri292 – 30918C4-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. nucleotide-excision repair Source: InterPro
  3. protein phosphorylation Source: GOC
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_206206. RNA Polymerase I Transcription Initiation.
REACT_214635. Dual incision reaction in GG-NER.
REACT_216241. RNA Polymerase II Pre-transcription Events.
REACT_218876. RNA Polymerase I Promoter Escape.
REACT_219180. Formation of incision complex in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 2
Alternative name(s):
Basic transcription factor 2 44 kDa subunit
Short name:
BTF2 p44
General transcription factor IIH polypeptide 2
TFIIH basal transcription factor complex p44 subunit
Gene namesi
Name:Gtf2h2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1310499. Gtf2h2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. core TFIIH complex Source: InterPro
  2. holo TFIIH complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396General transcription factor IIH subunit 2PRO_0000327566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA0JN27.
PRIDEiA0JN27.

PTM databases

PhosphoSiteiA0JN27.

Expressioni

Gene expression databases

GenevestigatoriA0JN27.

Interactioni

Subunit structurei

One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057895.

Structurei

3D structure databases

ProteinModelPortaliA0JN27.
SMRiA0JN27. Positions 329-387.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 236177VWFAAdd
BLAST

Sequence similaritiesi

Belongs to the GTF2H2 family.
Contains 1 VWFA domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri292 – 30918C4-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5151.
GeneTreeiENSGT00490000043395.
HOGENOMiHOG000159415.
HOVERGENiHBG059468.
KOiK03142.
OMAiECKVCGL.
OrthoDBiEOG7WQ7SP.
PhylomeDBiA0JN27.
TreeFamiTF314037.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR007087. Znf_C2H2.
[Graphical view]
PANTHERiPTHR12695. PTHR12695. 1 hit.
PfamiPF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
[Graphical view]
PIRSFiPIRSF015919. TFIIH_SSL1. 1 hit.
SMARTiSM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00622. ssl1. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JN27-1 [UniParc]FASTAAdd to Basket

« Hide

MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH    50
GQVRLGMMRH LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP 100
ISQIGIIVTK SKRAEKLTEL SGNPRKHITS LKKAVDMTCH GEPSLYNSLS 150
MAMQTLKHMP GHTSREVLII FSSLTTCDPS NIYDLIKTLK TAKIRVSVIG 200
LSAEVRVCTV LARETGGTYH VILDETHYKE LLARHVSPPP ASSGSECSLI 250
RMGFPQHTIA SLSDQDAKPS FSMAHLDNNS TEPGLTLGGY FCPQCRAKYC 300
ELPVECKICG LTLVSAPHLA RSYHHLFPLD AFQEIPLEEY KGERFCYGCQ 350
GELKDQHVYV CTVCRNVFCV DCDVFVHDSL HCCPGCVHKI PTQSGV 396
Length:396
Mass (Da):44,703
Last modified:December 12, 2006 - v1
Checksum:i2812ED7B0DC5B3C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126097 mRNA. Translation: AAI26098.1.
RefSeqiNP_001070896.1. NM_001077428.1.
XP_006231906.1. XM_006231844.1.
XP_006231907.1. XM_006231845.1.
UniGeneiRn.144260.

Genome annotation databases

EnsembliENSRNOT00000061183; ENSRNOP00000057895; ENSRNOG00000018230.
GeneIDi294693.
KEGGirno:294693.
UCSCiRGD:1310499. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126097 mRNA. Translation: AAI26098.1 .
RefSeqi NP_001070896.1. NM_001077428.1.
XP_006231906.1. XM_006231844.1.
XP_006231907.1. XM_006231845.1.
UniGenei Rn.144260.

3D structure databases

ProteinModelPortali A0JN27.
SMRi A0JN27. Positions 329-387.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000057895.

PTM databases

PhosphoSitei A0JN27.

Proteomic databases

PaxDbi A0JN27.
PRIDEi A0JN27.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000061183 ; ENSRNOP00000057895 ; ENSRNOG00000018230 .
GeneIDi 294693.
KEGGi rno:294693.
UCSCi RGD:1310499. rat.

Organism-specific databases

CTDi 2966.
RGDi 1310499. Gtf2h2.

Phylogenomic databases

eggNOGi COG5151.
GeneTreei ENSGT00490000043395.
HOGENOMi HOG000159415.
HOVERGENi HBG059468.
KOi K03142.
OMAi ECKVCGL.
OrthoDBi EOG7WQ7SP.
PhylomeDBi A0JN27.
TreeFami TF314037.

Enzyme and pathway databases

Reactomei REACT_206206. RNA Polymerase I Transcription Initiation.
REACT_214635. Dual incision reaction in GG-NER.
REACT_216241. RNA Polymerase II Pre-transcription Events.
REACT_218876. RNA Polymerase I Promoter Escape.
REACT_219180. Formation of incision complex in GG-NER.

Miscellaneous databases

NextBioi 638415.
PROi A0JN27.

Gene expression databases

Genevestigatori A0JN27.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR007087. Znf_C2H2.
[Graphical view ]
PANTHERi PTHR12695. PTHR12695. 1 hit.
Pfami PF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
[Graphical view ]
PIRSFi PIRSF015919. TFIIH_SSL1. 1 hit.
SMARTi SM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
TIGRFAMsi TIGR00622. ssl1. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTF2H2_RAT
AccessioniPrimary (citable) accession number: A0JN27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 12, 2006
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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