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A0JN27 (TF2H2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
General transcription factor IIH subunit 2
Alternative name(s):
Basic transcription factor 2 44 kDa subunit
Short name=BTF2 p44
General transcription factor IIH polypeptide 2
TFIIH basal transcription factor complex p44 subunit
Gene names
Name:Gtf2h2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter By similarity.

Subunit structure

One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the GTF2H2 family.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396General transcription factor IIH subunit 2
PRO_0000327566

Regions

Domain60 – 236177VWFA
Zinc finger292 – 30918C4-type

Sequences

Sequence LengthMass (Da)Tools
A0JN27 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 2812ED7B0DC5B3C8

FASTA39644,703
        10         20         30         40         50         60 
MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH 

        70         80         90        100        110        120 
LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL 

       130        140        150        160        170        180 
SGNPRKHITS LKKAVDMTCH GEPSLYNSLS MAMQTLKHMP GHTSREVLII FSSLTTCDPS 

       190        200        210        220        230        240 
NIYDLIKTLK TAKIRVSVIG LSAEVRVCTV LARETGGTYH VILDETHYKE LLARHVSPPP 

       250        260        270        280        290        300 
ASSGSECSLI RMGFPQHTIA SLSDQDAKPS FSMAHLDNNS TEPGLTLGGY FCPQCRAKYC 

       310        320        330        340        350        360 
ELPVECKICG LTLVSAPHLA RSYHHLFPLD AFQEIPLEEY KGERFCYGCQ GELKDQHVYV 

       370        380        390 
CTVCRNVFCV DCDVFVHDSL HCCPGCVHKI PTQSGV

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC126097 mRNA. Translation: AAI26098.1.
IPIIPI00776942.
RefSeqNP_001070896.1. NM_001077428.1.
UniGeneRn.144260.

3D structure databases

ProteinModelPortalA0JN27.
SMRA0JN27. Positions 329-387.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000057895.

PTM databases

PhosphoSiteA0JN27.

Proteomic databases

PaxDbA0JN27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000061183; ENSRNOP00000057895; ENSRNOG00000018230.
GeneID294693.
KEGGrno:294693.
UCSCRGD:1310499. rat.

Organism-specific databases

CTD2966.
RGD1310499. Gtf2h2.

Phylogenomic databases

eggNOGCOG5151.
GeneTreeENSGT00490000043395.
HOGENOMHOG000159415.
HOVERGENHBG059468.
KOK03142.
OrthoDBEOG4M0F1X.

Gene expression databases

ArrayExpressA0JN27.
GenevestigatorA0JN27.

Family and domain databases

InterProIPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR007087. Znf_C2H2.
[Graphical view]
PANTHERPTHR12695. PTHR12695. 1 hit.
PfamPF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
[Graphical view]
PIRSFPIRSF015919. TFIIH_SSL1. 1 hit.
SMARTSM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00622. ssl1. 1 hit.
PROSITEPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio638415.

Entry information

Entry nameTF2H2_RAT
AccessionPrimary (citable) accession number: A0JN27
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 12, 2006
Last modified: May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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