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A0JN27

- TF2H2_RAT

UniProt

A0JN27 - TF2H2_RAT

Protein

General transcription factor IIH subunit 2

Gene

Gtf2h2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri292 – 30918C4-typeAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. nucleotide-excision repair Source: InterPro
    3. protein phosphorylation Source: GOC
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_206206. RNA Polymerase I Transcription Initiation.
    REACT_214635. Dual incision reaction in GG-NER.
    REACT_216241. RNA Polymerase II Pre-transcription Events.
    REACT_218876. RNA Polymerase I Promoter Escape.
    REACT_219180. Formation of incision complex in GG-NER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor IIH subunit 2
    Alternative name(s):
    Basic transcription factor 2 44 kDa subunit
    Short name:
    BTF2 p44
    General transcription factor IIH polypeptide 2
    TFIIH basal transcription factor complex p44 subunit
    Gene namesi
    Name:Gtf2h2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi1310499. Gtf2h2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. core TFIIH complex Source: InterPro
    2. holo TFIIH complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396General transcription factor IIH subunit 2PRO_0000327566Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei95 – 951Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiA0JN27.
    PRIDEiA0JN27.

    PTM databases

    PhosphoSiteiA0JN27.

    Expressioni

    Gene expression databases

    GenevestigatoriA0JN27.

    Interactioni

    Subunit structurei

    One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000057895.

    Structurei

    3D structure databases

    ProteinModelPortaliA0JN27.
    SMRiA0JN27. Positions 329-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 236177VWFAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GTF2H2 family.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri292 – 30918C4-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5151.
    GeneTreeiENSGT00490000043395.
    HOGENOMiHOG000159415.
    HOVERGENiHBG059468.
    KOiK03142.
    OMAiECKVCGL.
    OrthoDBiEOG7WQ7SP.
    PhylomeDBiA0JN27.
    TreeFamiTF314037.

    Family and domain databases

    Gene3Di3.40.50.410. 1 hit.
    InterProiIPR007198. Ssl1-like.
    IPR004595. TFIIH_C1-like_dom.
    IPR012170. TFIIH_SSL1/p44.
    IPR002035. VWF_A.
    IPR007087. Znf_C2H2.
    [Graphical view]
    PANTHERiPTHR12695. PTHR12695. 1 hit.
    PfamiPF07975. C1_4. 1 hit.
    PF04056. Ssl1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015919. TFIIH_SSL1. 1 hit.
    SMARTiSM01047. C1_4. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    TIGRFAMsiTIGR00622. ssl1. 1 hit.
    PROSITEiPS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JN27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH    50
    GQVRLGMMRH LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP 100
    ISQIGIIVTK SKRAEKLTEL SGNPRKHITS LKKAVDMTCH GEPSLYNSLS 150
    MAMQTLKHMP GHTSREVLII FSSLTTCDPS NIYDLIKTLK TAKIRVSVIG 200
    LSAEVRVCTV LARETGGTYH VILDETHYKE LLARHVSPPP ASSGSECSLI 250
    RMGFPQHTIA SLSDQDAKPS FSMAHLDNNS TEPGLTLGGY FCPQCRAKYC 300
    ELPVECKICG LTLVSAPHLA RSYHHLFPLD AFQEIPLEEY KGERFCYGCQ 350
    GELKDQHVYV CTVCRNVFCV DCDVFVHDSL HCCPGCVHKI PTQSGV 396
    Length:396
    Mass (Da):44,703
    Last modified:December 12, 2006 - v1
    Checksum:i2812ED7B0DC5B3C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126097 mRNA. Translation: AAI26098.1.
    RefSeqiNP_001070896.1. NM_001077428.1.
    XP_006231906.1. XM_006231844.1.
    XP_006231907.1. XM_006231845.1.
    UniGeneiRn.144260.

    Genome annotation databases

    EnsembliENSRNOT00000061183; ENSRNOP00000057895; ENSRNOG00000018230.
    GeneIDi294693.
    KEGGirno:294693.
    UCSCiRGD:1310499. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126097 mRNA. Translation: AAI26098.1 .
    RefSeqi NP_001070896.1. NM_001077428.1.
    XP_006231906.1. XM_006231844.1.
    XP_006231907.1. XM_006231845.1.
    UniGenei Rn.144260.

    3D structure databases

    ProteinModelPortali A0JN27.
    SMRi A0JN27. Positions 329-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000057895.

    PTM databases

    PhosphoSitei A0JN27.

    Proteomic databases

    PaxDbi A0JN27.
    PRIDEi A0JN27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000061183 ; ENSRNOP00000057895 ; ENSRNOG00000018230 .
    GeneIDi 294693.
    KEGGi rno:294693.
    UCSCi RGD:1310499. rat.

    Organism-specific databases

    CTDi 2966.
    RGDi 1310499. Gtf2h2.

    Phylogenomic databases

    eggNOGi COG5151.
    GeneTreei ENSGT00490000043395.
    HOGENOMi HOG000159415.
    HOVERGENi HBG059468.
    KOi K03142.
    OMAi ECKVCGL.
    OrthoDBi EOG7WQ7SP.
    PhylomeDBi A0JN27.
    TreeFami TF314037.

    Enzyme and pathway databases

    Reactomei REACT_206206. RNA Polymerase I Transcription Initiation.
    REACT_214635. Dual incision reaction in GG-NER.
    REACT_216241. RNA Polymerase II Pre-transcription Events.
    REACT_218876. RNA Polymerase I Promoter Escape.
    REACT_219180. Formation of incision complex in GG-NER.

    Miscellaneous databases

    NextBioi 638415.
    PROi A0JN27.

    Gene expression databases

    Genevestigatori A0JN27.

    Family and domain databases

    Gene3Di 3.40.50.410. 1 hit.
    InterProi IPR007198. Ssl1-like.
    IPR004595. TFIIH_C1-like_dom.
    IPR012170. TFIIH_SSL1/p44.
    IPR002035. VWF_A.
    IPR007087. Znf_C2H2.
    [Graphical view ]
    PANTHERi PTHR12695. PTHR12695. 1 hit.
    Pfami PF07975. C1_4. 1 hit.
    PF04056. Ssl1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015919. TFIIH_SSL1. 1 hit.
    SMARTi SM01047. C1_4. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    TIGRFAMsi TIGR00622. ssl1. 1 hit.
    PROSITEi PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTF2H2_RAT
    AccessioniPrimary (citable) accession number: A0JN27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3