ID   RBM5A_XENLA             Reviewed;         833 AA.
AC   A0JMV4;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=RNA-binding protein 5-A;
DE   AltName: Full=RNA-binding motif protein 5-A;
GN   Name=rbm5-a; Synonyms=rbm5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the spliceosome A complex. Regulates alternative
CC       splicing of a number of mRNAs. May modulate splice site pairing after
CC       recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of
CC       the intron (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the spliceosome A complex (also known as the
CC       prespliceosome). Appears to dissociate from the spliceosome upon
CC       formation of the spliceosome B complex (also known as the precatalytic
CC       spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RBM5/RBM10 family. {ECO:0000305}.
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DR   EMBL; BC126019; AAI26020.1; -; mRNA.
DR   RefSeq; NP_001090434.1; NM_001096965.1.
DR   RefSeq; XP_018112478.1; XM_018256989.1.
DR   AlphaFoldDB; A0JMV4; -.
DR   DNASU; 779346; -.
DR   GeneID; 779346; -.
DR   KEGG; xla:779346; -.
DR   AGR; Xenbase:XB-GENE-494991; -.
DR   CTD; 779346; -.
DR   Xenbase; XB-GENE-494991; rbm5.L.
DR   OMA; CESEHER; -.
DR   OrthoDB; 298711at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 779346; Expressed in brain and 19 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0000245; P:spliceosomal complex assembly; ISS:UniProtKB.
DR   CDD; cd16168; OCRE_RBM5; 1.
DR   CDD; cd12752; RRM1_RBM5; 1.
DR   CDD; cd12755; RRM2_RBM5; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR041591; OCRE.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034991; RBM5_RRM1.
DR   InterPro; IPR034993; RBM5_RRM2.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR001876; Znf_RanBP2.
DR   InterPro; IPR036443; Znf_RanBP2_sf.
DR   PANTHER; PTHR13948; RNA-BINDING PROTEIN; 1.
DR   PANTHER; PTHR13948:SF21; RNA-BINDING PROTEIN 5; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   Pfam; PF17780; OCRE; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   Pfam; PF00641; zf-RanBP; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00360; RRM; 2.
DR   SMART; SM00547; ZnF_RBZ; 1.
DR   SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS50102; RRM; 2.
DR   PROSITE; PS01358; ZF_RANBP2_1; 1.
DR   PROSITE; PS50199; ZF_RANBP2_2; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Repeat; RNA-binding; Spliceosome; Zinc; Zinc-finger.
FT   CHAIN           1..833
FT                   /note="RNA-binding protein 5-A"
FT                   /id="PRO_0000376806"
FT   DOMAIN          102..182
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          241..325
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          761..807
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   ZN_FING         185..214
FT                   /note="RanBP2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00322"
FT   ZN_FING         667..692
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..458
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..454
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..540
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        542..559
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   833 AA;  93839 MW;  DF5F404E410EB8EE CRC64;
     MGSDKRVSRS ERSGRYGSGF DRDDRDDRDN RSRRRDSEYK RYRDERSDRY DDYRDYDSPE
     RDRMRDRERR NSDRSEDGYH SDGDYMDHDY RQDYYMDEKE SKTIMLRGLP ININENDIRE
     LVESFEGPQP ADVRLMKRKT GLSRGFAFVE FYHLQDSTSW MEANQKKLVI QGKTIAMHYS
     NPRPKFEDWL CNKCGLYNFR RRLKCFRCGA AKAESDMEAP SGSSEAPQSA DYYSDSGYVS
     SAIILRNIGP HTVVDSILSA LAPYVSLVVS NIRLIKDKQT QQNRGFAFVQ LPSALEASQL
     LQILQTLHPP LKIDGKTIGV DFAKSARKDL VLPDGHRVSA FSVASTAIAA AQWSSTQPAQ
     QSGEGGDYAY LQPGQEGCSN YGQCSQDYQP FYQTQTGAAE QGTAPQAESS SPVPATTSAV
     VCQSPQMYQQ PGSPTQSSTS TVAASATPAS GTSAEEAAAP NAIVPGLKYS VPDTSTYQYD
     ESSGYYYDPQ TGLYYDPNSQ YYYNSLTQQY LYWDGEKQTY LPAADGAGQS GTQPNGANPG
     TSKEGKEKKE KPKSKTAQQI AKDMERWAKS LNKQKENFKN SFQPLRDEER KESAAADAGF
     ALFEKKQGSL LERQFLPDMM MMVNTEEEKP PNTALVAAYS GDSDNEEENE RFIGAVDDEK
     LMDWKKLACL LCRRQFPNKD ALTRHQQLSD LHKQNLEVYR RSKLSEQEYE AEQTERESKY
     RDRAAERRVK YGIPEPPEPK RKRFAPTVVN YEQPTKDGID NSNIGNKMLQ AMGWKEGSGL
     GRKSQGITAP IQAQVRMRGA GLGAKGSSYG VNTSDSYKDA VRKAMFARFS EME
//