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A0JMV4

- RBM5A_XENLA

UniProt

A0JMV4 - RBM5A_XENLA

Protein

RNA-binding protein 5-A

Gene

rbm5-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri185 – 21430RanBP2-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri667 – 69226C2H2-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. mRNA binding Source: UniProtKB
    2. nucleotide binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of apoptotic process Source: UniProtKB
    2. regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
    3. spliceosomal complex assembly Source: UniProtKB

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-binding protein 5-A
    Alternative name(s):
    RNA-binding motif protein 5-A
    Gene namesi
    Name:rbm5-a
    Synonyms:rbm5
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-494991. rbm5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. spliceosomal complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 833833RNA-binding protein 5-APRO_0000376806Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound By similarity.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini102 – 18281RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini241 – 32585RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini761 – 80747G-patchPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 7469Arg-richAdd
    BLAST
    Compositional biasi477 – 51236Tyr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RBM5/RBM10 family.Curated
    Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
    Contains 1 G-patch domain.PROSITE-ProRule annotation
    Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri185 – 21430RanBP2-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri667 – 69226C2H2-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    KOiK13094.

    Family and domain databases

    Gene3Di3.30.70.330. 2 hits.
    4.10.1060.10. 1 hit.
    InterProiIPR000467. G_patch_dom.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR001876. Znf_RanBP2.
    [Graphical view]
    PfamiPF01585. G-patch. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view]
    SMARTiSM00443. G_patch. 1 hit.
    SM00360. RRM. 2 hits.
    SM00355. ZnF_C2H2. 1 hit.
    SM00547. ZnF_RBZ. 1 hit.
    [Graphical view]
    PROSITEiPS50174. G_PATCH. 1 hit.
    PS50102. RRM. 2 hits.
    PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JMV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSDKRVSRS ERSGRYGSGF DRDDRDDRDN RSRRRDSEYK RYRDERSDRY    50
    DDYRDYDSPE RDRMRDRERR NSDRSEDGYH SDGDYMDHDY RQDYYMDEKE 100
    SKTIMLRGLP ININENDIRE LVESFEGPQP ADVRLMKRKT GLSRGFAFVE 150
    FYHLQDSTSW MEANQKKLVI QGKTIAMHYS NPRPKFEDWL CNKCGLYNFR 200
    RRLKCFRCGA AKAESDMEAP SGSSEAPQSA DYYSDSGYVS SAIILRNIGP 250
    HTVVDSILSA LAPYVSLVVS NIRLIKDKQT QQNRGFAFVQ LPSALEASQL 300
    LQILQTLHPP LKIDGKTIGV DFAKSARKDL VLPDGHRVSA FSVASTAIAA 350
    AQWSSTQPAQ QSGEGGDYAY LQPGQEGCSN YGQCSQDYQP FYQTQTGAAE 400
    QGTAPQAESS SPVPATTSAV VCQSPQMYQQ PGSPTQSSTS TVAASATPAS 450
    GTSAEEAAAP NAIVPGLKYS VPDTSTYQYD ESSGYYYDPQ TGLYYDPNSQ 500
    YYYNSLTQQY LYWDGEKQTY LPAADGAGQS GTQPNGANPG TSKEGKEKKE 550
    KPKSKTAQQI AKDMERWAKS LNKQKENFKN SFQPLRDEER KESAAADAGF 600
    ALFEKKQGSL LERQFLPDMM MMVNTEEEKP PNTALVAAYS GDSDNEEENE 650
    RFIGAVDDEK LMDWKKLACL LCRRQFPNKD ALTRHQQLSD LHKQNLEVYR 700
    RSKLSEQEYE AEQTERESKY RDRAAERRVK YGIPEPPEPK RKRFAPTVVN 750
    YEQPTKDGID NSNIGNKMLQ AMGWKEGSGL GRKSQGITAP IQAQVRMRGA 800
    GLGAKGSSYG VNTSDSYKDA VRKAMFARFS EME 833
    Length:833
    Mass (Da):93,839
    Last modified:December 12, 2006 - v1
    Checksum:iDF5F404E410EB8EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126019 mRNA. Translation: AAI26020.1.
    RefSeqiNP_001090434.1. NM_001096965.1.
    UniGeneiXl.7259.

    Genome annotation databases

    GeneIDi779346.
    KEGGixla:779346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC126019 mRNA. Translation: AAI26020.1 .
    RefSeqi NP_001090434.1. NM_001096965.1.
    UniGenei Xl.7259.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 779346.
    KEGGi xla:779346.

    Organism-specific databases

    CTDi 779346.
    Xenbasei XB-GENE-494991. rbm5.

    Phylogenomic databases

    KOi K13094.

    Family and domain databases

    Gene3Di 3.30.70.330. 2 hits.
    4.10.1060.10. 1 hit.
    InterProi IPR000467. G_patch_dom.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR001876. Znf_RanBP2.
    [Graphical view ]
    Pfami PF01585. G-patch. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view ]
    SMARTi SM00443. G_patch. 1 hit.
    SM00360. RRM. 2 hits.
    SM00355. ZnF_C2H2. 1 hit.
    SM00547. ZnF_RBZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50174. G_PATCH. 1 hit.
    PS50102. RRM. 2 hits.
    PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiRBM5A_XENLA
    AccessioniPrimary (citable) accession number: A0JMV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3