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A0JMV4

- RBM5A_XENLA

UniProt

A0JMV4 - RBM5A_XENLA

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Protein

RNA-binding protein 5-A

Gene
rbm5-a, rbm5
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri185 – 21430RanBP2-typeAdd
BLAST
Zinc fingeri667 – 69226C2H2-typeAdd
BLAST

GO - Molecular functioni

  1. mRNA binding Source: UniProtKB
  2. nucleotide binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of apoptotic process Source: UniProtKB
  2. regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
  3. spliceosomal complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 5-A
Alternative name(s):
RNA-binding motif protein 5-A
Gene namesi
Name:rbm5-a
Synonyms:rbm5
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-494991. rbm5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. spliceosomal complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833RNA-binding protein 5-APRO_0000376806Add
BLAST

Interactioni

Subunit structurei

Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 18281RRM 1Add
BLAST
Domaini241 – 32585RRM 2Add
BLAST
Domaini761 – 80747G-patchAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 7469Arg-richAdd
BLAST
Compositional biasi477 – 51236Tyr-richAdd
BLAST

Sequence similaritiesi

Belongs to the RBM5/RBM10 family.
Contains 1 G-patch domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri185 – 21430RanBP2-typeAdd
BLAST
Zinc fingeri667 – 69226C2H2-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

KOiK13094.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JMV4-1 [UniParc]FASTAAdd to Basket

« Hide

MGSDKRVSRS ERSGRYGSGF DRDDRDDRDN RSRRRDSEYK RYRDERSDRY    50
DDYRDYDSPE RDRMRDRERR NSDRSEDGYH SDGDYMDHDY RQDYYMDEKE 100
SKTIMLRGLP ININENDIRE LVESFEGPQP ADVRLMKRKT GLSRGFAFVE 150
FYHLQDSTSW MEANQKKLVI QGKTIAMHYS NPRPKFEDWL CNKCGLYNFR 200
RRLKCFRCGA AKAESDMEAP SGSSEAPQSA DYYSDSGYVS SAIILRNIGP 250
HTVVDSILSA LAPYVSLVVS NIRLIKDKQT QQNRGFAFVQ LPSALEASQL 300
LQILQTLHPP LKIDGKTIGV DFAKSARKDL VLPDGHRVSA FSVASTAIAA 350
AQWSSTQPAQ QSGEGGDYAY LQPGQEGCSN YGQCSQDYQP FYQTQTGAAE 400
QGTAPQAESS SPVPATTSAV VCQSPQMYQQ PGSPTQSSTS TVAASATPAS 450
GTSAEEAAAP NAIVPGLKYS VPDTSTYQYD ESSGYYYDPQ TGLYYDPNSQ 500
YYYNSLTQQY LYWDGEKQTY LPAADGAGQS GTQPNGANPG TSKEGKEKKE 550
KPKSKTAQQI AKDMERWAKS LNKQKENFKN SFQPLRDEER KESAAADAGF 600
ALFEKKQGSL LERQFLPDMM MMVNTEEEKP PNTALVAAYS GDSDNEEENE 650
RFIGAVDDEK LMDWKKLACL LCRRQFPNKD ALTRHQQLSD LHKQNLEVYR 700
RSKLSEQEYE AEQTERESKY RDRAAERRVK YGIPEPPEPK RKRFAPTVVN 750
YEQPTKDGID NSNIGNKMLQ AMGWKEGSGL GRKSQGITAP IQAQVRMRGA 800
GLGAKGSSYG VNTSDSYKDA VRKAMFARFS EME 833
Length:833
Mass (Da):93,839
Last modified:December 12, 2006 - v1
Checksum:iDF5F404E410EB8EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126019 mRNA. Translation: AAI26020.1.
RefSeqiNP_001090434.1. NM_001096965.1.
UniGeneiXl.7259.

Genome annotation databases

GeneIDi779346.
KEGGixla:779346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126019 mRNA. Translation: AAI26020.1 .
RefSeqi NP_001090434.1. NM_001096965.1.
UniGenei Xl.7259.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 779346.
KEGGi xla:779346.

Organism-specific databases

CTDi 779346.
Xenbasei XB-GENE-494991. rbm5.

Phylogenomic databases

KOi K13094.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProi IPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR001876. Znf_RanBP2.
[Graphical view ]
Pfami PF01585. G-patch. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view ]
SMARTi SM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view ]
PROSITEi PS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiRBM5A_XENLA
AccessioniPrimary (citable) accession number: A0JMV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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