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A0JMV4

- RBM5A_XENLA

UniProt

A0JMV4 - RBM5A_XENLA

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Protein

RNA-binding protein 5-A

Gene

rbm5-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri185 – 21430RanBP2-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri667 – 69226C2H2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. mRNA binding Source: UniProtKB
  2. nucleotide binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of apoptotic process Source: UniProtKB
  2. regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
  3. spliceosomal complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 5-A
Alternative name(s):
RNA-binding motif protein 5-A
Gene namesi
Name:rbm5-a
Synonyms:rbm5
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-494991. rbm5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. spliceosomal complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833RNA-binding protein 5-APRO_0000376806Add
BLAST

Interactioni

Subunit structurei

Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound (By similarity).By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 18281RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini241 – 32585RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini761 – 80747G-patchPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 7469Arg-richAdd
BLAST
Compositional biasi477 – 51236Tyr-richAdd
BLAST

Sequence similaritiesi

Belongs to the RBM5/RBM10 family.Curated
Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri185 – 21430RanBP2-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri667 – 69226C2H2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

KOiK13094.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JMV4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSDKRVSRS ERSGRYGSGF DRDDRDDRDN RSRRRDSEYK RYRDERSDRY
60 70 80 90 100
DDYRDYDSPE RDRMRDRERR NSDRSEDGYH SDGDYMDHDY RQDYYMDEKE
110 120 130 140 150
SKTIMLRGLP ININENDIRE LVESFEGPQP ADVRLMKRKT GLSRGFAFVE
160 170 180 190 200
FYHLQDSTSW MEANQKKLVI QGKTIAMHYS NPRPKFEDWL CNKCGLYNFR
210 220 230 240 250
RRLKCFRCGA AKAESDMEAP SGSSEAPQSA DYYSDSGYVS SAIILRNIGP
260 270 280 290 300
HTVVDSILSA LAPYVSLVVS NIRLIKDKQT QQNRGFAFVQ LPSALEASQL
310 320 330 340 350
LQILQTLHPP LKIDGKTIGV DFAKSARKDL VLPDGHRVSA FSVASTAIAA
360 370 380 390 400
AQWSSTQPAQ QSGEGGDYAY LQPGQEGCSN YGQCSQDYQP FYQTQTGAAE
410 420 430 440 450
QGTAPQAESS SPVPATTSAV VCQSPQMYQQ PGSPTQSSTS TVAASATPAS
460 470 480 490 500
GTSAEEAAAP NAIVPGLKYS VPDTSTYQYD ESSGYYYDPQ TGLYYDPNSQ
510 520 530 540 550
YYYNSLTQQY LYWDGEKQTY LPAADGAGQS GTQPNGANPG TSKEGKEKKE
560 570 580 590 600
KPKSKTAQQI AKDMERWAKS LNKQKENFKN SFQPLRDEER KESAAADAGF
610 620 630 640 650
ALFEKKQGSL LERQFLPDMM MMVNTEEEKP PNTALVAAYS GDSDNEEENE
660 670 680 690 700
RFIGAVDDEK LMDWKKLACL LCRRQFPNKD ALTRHQQLSD LHKQNLEVYR
710 720 730 740 750
RSKLSEQEYE AEQTERESKY RDRAAERRVK YGIPEPPEPK RKRFAPTVVN
760 770 780 790 800
YEQPTKDGID NSNIGNKMLQ AMGWKEGSGL GRKSQGITAP IQAQVRMRGA
810 820 830
GLGAKGSSYG VNTSDSYKDA VRKAMFARFS EME
Length:833
Mass (Da):93,839
Last modified:December 12, 2006 - v1
Checksum:iDF5F404E410EB8EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126019 mRNA. Translation: AAI26020.1.
RefSeqiNP_001090434.1. NM_001096965.1.
UniGeneiXl.7259.

Genome annotation databases

GeneIDi779346.
KEGGixla:779346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC126019 mRNA. Translation: AAI26020.1 .
RefSeqi NP_001090434.1. NM_001096965.1.
UniGenei Xl.7259.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 779346.
KEGGi xla:779346.

Organism-specific databases

CTDi 779346.
Xenbasei XB-GENE-494991. rbm5.

Phylogenomic databases

KOi K13094.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProi IPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR001876. Znf_RanBP2.
[Graphical view ]
Pfami PF01585. G-patch. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view ]
SMARTi SM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view ]
PROSITEi PS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiRBM5A_XENLA
AccessioniPrimary (citable) accession number: A0JMV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: December 12, 2006
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3