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A0JMV4 (RBM5A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-binding protein 5-A
Alternative name(s):
RNA-binding motif protein 5-A
Gene names
Name:rbm5-a
Synonyms:rbm5
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length833 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron By similarity.

Subunit structure

Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the RBM5/RBM10 family.

Contains 1 C2H2-type zinc finger.

Contains 1 G-patch domain.

Contains 1 RanBP2-type zinc finger.

Contains 2 RRM (RNA recognition motif) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 833833RNA-binding protein 5-A
PRO_0000376806

Regions

Domain102 – 18281RRM 1
Domain241 – 32585RRM 2
Domain761 – 80747G-patch
Zinc finger185 – 21430RanBP2-type
Zinc finger667 – 69226C2H2-type
Compositional bias6 – 7469Arg-rich
Compositional bias477 – 51236Tyr-rich

Sequences

Sequence LengthMass (Da)Tools
A0JMV4 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: DF5F404E410EB8EE

FASTA83393,839
        10         20         30         40         50         60 
MGSDKRVSRS ERSGRYGSGF DRDDRDDRDN RSRRRDSEYK RYRDERSDRY DDYRDYDSPE 

        70         80         90        100        110        120 
RDRMRDRERR NSDRSEDGYH SDGDYMDHDY RQDYYMDEKE SKTIMLRGLP ININENDIRE 

       130        140        150        160        170        180 
LVESFEGPQP ADVRLMKRKT GLSRGFAFVE FYHLQDSTSW MEANQKKLVI QGKTIAMHYS 

       190        200        210        220        230        240 
NPRPKFEDWL CNKCGLYNFR RRLKCFRCGA AKAESDMEAP SGSSEAPQSA DYYSDSGYVS 

       250        260        270        280        290        300 
SAIILRNIGP HTVVDSILSA LAPYVSLVVS NIRLIKDKQT QQNRGFAFVQ LPSALEASQL 

       310        320        330        340        350        360 
LQILQTLHPP LKIDGKTIGV DFAKSARKDL VLPDGHRVSA FSVASTAIAA AQWSSTQPAQ 

       370        380        390        400        410        420 
QSGEGGDYAY LQPGQEGCSN YGQCSQDYQP FYQTQTGAAE QGTAPQAESS SPVPATTSAV 

       430        440        450        460        470        480 
VCQSPQMYQQ PGSPTQSSTS TVAASATPAS GTSAEEAAAP NAIVPGLKYS VPDTSTYQYD 

       490        500        510        520        530        540 
ESSGYYYDPQ TGLYYDPNSQ YYYNSLTQQY LYWDGEKQTY LPAADGAGQS GTQPNGANPG 

       550        560        570        580        590        600 
TSKEGKEKKE KPKSKTAQQI AKDMERWAKS LNKQKENFKN SFQPLRDEER KESAAADAGF 

       610        620        630        640        650        660 
ALFEKKQGSL LERQFLPDMM MMVNTEEEKP PNTALVAAYS GDSDNEEENE RFIGAVDDEK 

       670        680        690        700        710        720 
LMDWKKLACL LCRRQFPNKD ALTRHQQLSD LHKQNLEVYR RSKLSEQEYE AEQTERESKY 

       730        740        750        760        770        780 
RDRAAERRVK YGIPEPPEPK RKRFAPTVVN YEQPTKDGID NSNIGNKMLQ AMGWKEGSGL 

       790        800        810        820        830 
GRKSQGITAP IQAQVRMRGA GLGAKGSSYG VNTSDSYKDA VRKAMFARFS EME 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC126019 mRNA. Translation: AAI26020.1.
RefSeqNP_001090434.1. NM_001096965.1.
UniGeneXl.7259.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID779346.
KEGGxla:779346.

Organism-specific databases

CTD779346.
XenbaseXB-GENE-494991. rbm5.

Phylogenomic databases

KOK13094.

Family and domain databases

Gene3D3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamPF01585. G-patch. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
PROSITEPS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRBM5A_XENLA
AccessionPrimary (citable) accession number: A0JMV4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families