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Protein

Histone H2A deubiquitinase MYSM1

Gene

mysm1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi627 – 6271Zinc; catalyticBy similarity
Metal bindingi629 – 6291Zinc; catalyticBy similarity
Metal bindingi640 – 6401Zinc; catalyticBy similarity

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. DNA binding Source: UniProtKB-KW
  3. histone binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. metallopeptidase activity Source: UniProtKB
  6. transcription coactivator activity Source: UniProtKB
  7. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. chromatin remodeling Source: UniProtKB
  2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Protein family/group databases

MEROPSiM67.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A deubiquitinase MYSM1 (EC:3.4.19.-)
Short name:
2A-DUB
Alternative name(s):
Myb-like, SWIRM and MPN domain-containing protein 1
Gene namesi
Name:mysm1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1032962. mysm1.

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 818818Histone H2A deubiquitinase MYSM1PRO_0000373926Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA0JMR6.
SMRiA0JMR6. Positions 110-159, 337-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 15852SANTPROSITE-ProRule annotationAdd
BLAST
Domaini344 – 44299SWIRMPROSITE-ProRule annotationAdd
BLAST
Domaini543 – 653111MPNAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi627 – 64014JAMM motifAdd
BLAST
Motifi745 – 7495LXXLL motif

Domaini

Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA (By similarity).By similarity

Sequence similaritiesi

Belongs to the peptidase M67A family. MYSM1 subfamily.Curated
Contains 1 MPN (JAB/Mov34) domain.Curated
Contains 1 SANT domain.PROSITE-ProRule annotation
Contains 1 SWIRM domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK11865.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR000555. JAMM/MPN+_dom.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JMR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEAADVDI DIEGDINESS KSIYDSLNTG FAPEHYIESA WQNEEGLAPW
60 70 80 90 100
ALDSSISEEN REAIKKMLLE EEYYLSNKPL AVKFWSDSQE GEKQCIKRVR
110 120 130 140 150
SPAKASSSPV KWTKEEKNLF EQGLATFGRR WTSIARLIGS RSVLQVKNYA
160 170 180 190 200
RHYFKNKCKL EGFVKEEAKI GSLQIPNLQD YENEPDITDE PTTFRGRADP
210 220 230 240 250
NLNAIKIEKL SDDEEIDITD EVDELLSNKT NLDTIIIAKT DKVKETKVET
260 270 280 290 300
EVQQKSHSTT EHSQTDIPKL VLQQTETECL DSVNPLTCIT SPKWTLSPQQ
310 320 330 340 350
CEEDDYDQPD VQDCLQEKCL SPHAEDLTVL CENENDSQDE DDEIKPPDQE
360 370 380 390 400
LEIDRNFILD EEKQAIPEFF EGRQAKTPDR YLRIRNYILD QWENCKPKYL
410 420 430 440 450
NKTSVRPGLK NCGDVNCIGR IHTYLELIGA INFGCEQAIY NRPRPVDKTK
460 470 480 490 500
CKEGKDTLEA YKLAHRLQSM RTRKRRVRDP WGNWCDAKDL EGQTYEHLSA
510 520 530 540 550
EELARRHEDK IKSYKYSKGT RQVRSSFDPF QLIPCSAFSE EKKAPFQVKV
560 570 580 590 600
SCEAMLVLDL HAHVSMAEVI GLLGGRYTES ESVVEICAVE PCNSLSTGLQ
610 620 630 640 650
CEMDPVSQTQ ASEALASRGY SVIGWYHSHP AFDPNPSIRD IDTQAKYQNY
660 670 680 690 700
FSRGGAKFLG MIISPYNRRN PHPQSQVACL IISDELSNDG SYRIPYKFEI
710 720 730 740 750
EYMQGEPQWE LVFAKTRWII EKYRSSHSSV SMDKRFRHDS ELTCLQKLLM
760 770 780 790 800
CMKKTLGNTA CPLITEEFLH RIEEYFRTSY KKESNYQIED NDPCKQHSDT
810
TFTMDSFQDY EPNGRPSL
Length:818
Mass (Da):94,084
Last modified:December 12, 2006 - v1
Checksum:iE60F8B915E1CEBE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125979 mRNA. Translation: AAI25980.1.
RefSeqiNP_001090503.1. NM_001097034.1.
UniGeneiXl.3062.

Genome annotation databases

GeneIDi779416.
KEGGixla:779416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125979 mRNA. Translation: AAI25980.1.
RefSeqiNP_001090503.1. NM_001097034.1.
UniGeneiXl.3062.

3D structure databases

ProteinModelPortaliA0JMR6.
SMRiA0JMR6. Positions 110-159, 337-442.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM67.005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi779416.
KEGGixla:779416.

Organism-specific databases

CTDi114803.
XenbaseiXB-GENE-1032962. mysm1.

Phylogenomic databases

KOiK11865.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR000555. JAMM/MPN+_dom.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiMYSM1_XENLA
AccessioniPrimary (citable) accession number: A0JMR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: December 12, 2006
Last modified: March 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.