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A0JMR6

- MYSM1_XENLA

UniProt

A0JMR6 - MYSM1_XENLA

Protein

Histone H2A deubiquitinase MYSM1

Gene

mysm1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi627 – 6271Zinc; catalyticBy similarity
    Metal bindingi629 – 6291Zinc; catalyticBy similarity
    Metal bindingi640 – 6401Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. histone binding Source: UniProtKB
    4. metal ion binding Source: UniProtKB-KW
    5. metallopeptidase activity Source: UniProtKB
    6. transcription coactivator activity Source: UniProtKB
    7. ubiquitin-specific protease activity Source: UniProtKB
    8. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. chromatin remodeling Source: UniProtKB
    2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
    3. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM67.005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H2A deubiquitinase MYSM1 (EC:3.4.19.-)
    Short name:
    2A-DUB
    Alternative name(s):
    Myb-like, SWIRM and MPN domain-containing protein 1
    Gene namesi
    Name:mysm1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-1032962. mysm1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 818818Histone H2A deubiquitinase MYSM1PRO_0000373926Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA0JMR6.
    SMRiA0JMR6. Positions 110-159, 337-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini107 – 15852SANTPROSITE-ProRule annotationAdd
    BLAST
    Domaini344 – 44299SWIRMPROSITE-ProRule annotationAdd
    BLAST
    Domaini543 – 653111MPNAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi627 – 64014JAMM motifAdd
    BLAST
    Motifi745 – 7495LXXLL motif

    Domaini

    Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA By similarity.By similarity

    Sequence similaritiesi

    Belongs to the peptidase M67A family. MYSM1 subfamily.Curated
    Contains 1 MPN (JAB/Mov34) domain.Curated
    Contains 1 SANT domain.PROSITE-ProRule annotation
    Contains 1 SWIRM domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK11865.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.10.60. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR000555. JAMM/MPN+_dom.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR007526. SWIRM.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01398. JAB. 1 hit.
    PF00249. Myb_DNA-binding. 1 hit.
    PF04433. SWIRM. 1 hit.
    [Graphical view]
    SMARTiSM00232. JAB_MPN. 1 hit.
    SM00717. SANT. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS51293. SANT. 1 hit.
    PS50934. SWIRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JMR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEEAADVDI DIEGDINESS KSIYDSLNTG FAPEHYIESA WQNEEGLAPW    50
    ALDSSISEEN REAIKKMLLE EEYYLSNKPL AVKFWSDSQE GEKQCIKRVR 100
    SPAKASSSPV KWTKEEKNLF EQGLATFGRR WTSIARLIGS RSVLQVKNYA 150
    RHYFKNKCKL EGFVKEEAKI GSLQIPNLQD YENEPDITDE PTTFRGRADP 200
    NLNAIKIEKL SDDEEIDITD EVDELLSNKT NLDTIIIAKT DKVKETKVET 250
    EVQQKSHSTT EHSQTDIPKL VLQQTETECL DSVNPLTCIT SPKWTLSPQQ 300
    CEEDDYDQPD VQDCLQEKCL SPHAEDLTVL CENENDSQDE DDEIKPPDQE 350
    LEIDRNFILD EEKQAIPEFF EGRQAKTPDR YLRIRNYILD QWENCKPKYL 400
    NKTSVRPGLK NCGDVNCIGR IHTYLELIGA INFGCEQAIY NRPRPVDKTK 450
    CKEGKDTLEA YKLAHRLQSM RTRKRRVRDP WGNWCDAKDL EGQTYEHLSA 500
    EELARRHEDK IKSYKYSKGT RQVRSSFDPF QLIPCSAFSE EKKAPFQVKV 550
    SCEAMLVLDL HAHVSMAEVI GLLGGRYTES ESVVEICAVE PCNSLSTGLQ 600
    CEMDPVSQTQ ASEALASRGY SVIGWYHSHP AFDPNPSIRD IDTQAKYQNY 650
    FSRGGAKFLG MIISPYNRRN PHPQSQVACL IISDELSNDG SYRIPYKFEI 700
    EYMQGEPQWE LVFAKTRWII EKYRSSHSSV SMDKRFRHDS ELTCLQKLLM 750
    CMKKTLGNTA CPLITEEFLH RIEEYFRTSY KKESNYQIED NDPCKQHSDT 800
    TFTMDSFQDY EPNGRPSL 818
    Length:818
    Mass (Da):94,084
    Last modified:December 12, 2006 - v1
    Checksum:iE60F8B915E1CEBE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC125979 mRNA. Translation: AAI25980.1.
    RefSeqiNP_001090503.1. NM_001097034.1.
    UniGeneiXl.3062.

    Genome annotation databases

    GeneIDi779416.
    KEGGixla:779416.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC125979 mRNA. Translation: AAI25980.1 .
    RefSeqi NP_001090503.1. NM_001097034.1.
    UniGenei Xl.3062.

    3D structure databases

    ProteinModelPortali A0JMR6.
    SMRi A0JMR6. Positions 110-159, 337-442.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M67.005.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 779416.
    KEGGi xla:779416.

    Organism-specific databases

    CTDi 114803.
    Xenbasei XB-GENE-1032962. mysm1.

    Phylogenomic databases

    KOi K11865.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.10.60. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR000555. JAMM/MPN+_dom.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR007526. SWIRM.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01398. JAB. 1 hit.
    PF00249. Myb_DNA-binding. 1 hit.
    PF04433. SWIRM. 1 hit.
    [Graphical view ]
    SMARTi SM00232. JAB_MPN. 1 hit.
    SM00717. SANT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS51293. SANT. 1 hit.
    PS50934. SWIRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiMYSM1_XENLA
    AccessioniPrimary (citable) accession number: A0JMR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3