Histone H2A deubiquitinase MYSM1 - Xenopus laevis (African clawed frog)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Histone H2A deubiquitinase MYSM1
Short name=2A-DUB
EC=3.4.19.-

Alternative name(s):
Myb-like, SWIRM and MPN domain-containing protein 1

Gene names

Name:

mysm1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	818 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation By similarity.
Subcellular location	Nucleus By similarity.
Domain	Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA By similarity.
Sequence similarities	Belongs to the peptidase M67A family. MYSM1 subfamily. Contains 1 MPN (JAB/Mov34) domain. Contains 1 SANT domain. Contains 1 SWIRM domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Ubl conjugation pathway
Cellular component	Nucleus
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Chromatin regulator Hydrolase Metalloprotease Protease
Gene Ontology (GO)
Biological_process	histone deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB proteolysis Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW chromatin binding Inferred from electronic annotation. Source: InterPro histone binding Inferred from sequence or structural similarity. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from sequence or structural similarity. Source: UniProtKB transcription coactivator activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin thiolesterase activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-specific protease activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 818

818

Histone H2A deubiquitinase MYSM1

PRO_0000373926

Regions

Domain

107 – 158

52

SANT

Domain

344 – 442

99

SWIRM

Domain

543 – 653

111

MPN

Motif

627 – 640

14

JAMM motif

Motif

745 – 749

5

LXXLL motif

Sites

Metal binding

627

1

Zinc; catalytic By similarity

Metal binding

629

1

Zinc; catalytic By similarity

Metal binding

640

1

Zinc; catalytic By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

A0JMR6 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: E60F8B915E1CEBE0
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FASTA

818

94,084

        10         20         30         40         50         60 
MAEEAADVDI DIEGDINESS KSIYDSLNTG FAPEHYIESA WQNEEGLAPW ALDSSISEEN 

        70         80         90        100        110        120 
REAIKKMLLE EEYYLSNKPL AVKFWSDSQE GEKQCIKRVR SPAKASSSPV KWTKEEKNLF 

       130        140        150        160        170        180 
EQGLATFGRR WTSIARLIGS RSVLQVKNYA RHYFKNKCKL EGFVKEEAKI GSLQIPNLQD 

       190        200        210        220        230        240 
YENEPDITDE PTTFRGRADP NLNAIKIEKL SDDEEIDITD EVDELLSNKT NLDTIIIAKT 

       250        260        270        280        290        300 
DKVKETKVET EVQQKSHSTT EHSQTDIPKL VLQQTETECL DSVNPLTCIT SPKWTLSPQQ 

       310        320        330        340        350        360 
CEEDDYDQPD VQDCLQEKCL SPHAEDLTVL CENENDSQDE DDEIKPPDQE LEIDRNFILD 

       370        380        390        400        410        420 
EEKQAIPEFF EGRQAKTPDR YLRIRNYILD QWENCKPKYL NKTSVRPGLK NCGDVNCIGR 

       430        440        450        460        470        480 
IHTYLELIGA INFGCEQAIY NRPRPVDKTK CKEGKDTLEA YKLAHRLQSM RTRKRRVRDP 

       490        500        510        520        530        540 
WGNWCDAKDL EGQTYEHLSA EELARRHEDK IKSYKYSKGT RQVRSSFDPF QLIPCSAFSE 

       550        560        570        580        590        600 
EKKAPFQVKV SCEAMLVLDL HAHVSMAEVI GLLGGRYTES ESVVEICAVE PCNSLSTGLQ 

       610        620        630        640        650        660 
CEMDPVSQTQ ASEALASRGY SVIGWYHSHP AFDPNPSIRD IDTQAKYQNY FSRGGAKFLG 

       670        680        690        700        710        720 
MIISPYNRRN PHPQSQVACL IISDELSNDG SYRIPYKFEI EYMQGEPQWE LVFAKTRWII 

       730        740        750        760        770        780 
EKYRSSHSSV SMDKRFRHDS ELTCLQKLLM CMKKTLGNTA CPLITEEFLH RIEEYFRTSY 

       790        800        810 
KKESNYQIED NDPCKQHSDT TFTMDSFQDY EPNGRPSL

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References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC125979 mRNA. Translation: AAI25980.1.
RefSeq	NP_001090503.1. NM_001097034.1.
UniGene	Xl.3062.
3D structure databases
ProteinModelPortal	A0JMR6.
SMR	A0JMR6. Positions 110-159, 337-442.
ModBase	Search...
Protein family/group databases
MEROPS	M67.005.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	779416.
KEGG	xla:779416.
Organism-specific databases
CTD	114803.
Xenbase	XB-GENE-1032962. mysm1.
Phylogenomic databases
KO	K11865.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 1.10.10.60. 1 hit.
InterPro	IPR009057. Homeodomain-like. IPR000555. JAB1_Mov34_MPN_PAD1. IPR001005. SANT/Myb. IPR017884. SANT_dom. IPR007526. SWIRM. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF01398. JAB. 1 hit. PF00249. Myb_DNA-binding. 1 hit. PF04433. SWIRM. 1 hit. [Graphical view]
SMART	SM00232. JAB_MPN. 1 hit. SM00717. SANT. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 2 hits.
PROSITE	PS51293. SANT. 1 hit. PS50934. SWIRM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MYSM1_XENLA

Accession

Primary (citable) accession number: A0JMR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents