Reviewed,
UniProtKB/Swiss-Prot A0JMR6 (MYSM1_XENLA)
Last modified
October 13, 2009.
Version 24.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone H2A deubiquitinase MYSM1 Short name=2A-DUB EC=3.1.2.15 Alternative name(s): Myb-like, SWIRM and MPN domain-containing protein 1 | ||
| Gene names |
| ||
| Organism | Xenopus laevis (African clawed frog) | ||
| Taxonomic identifier | 8355 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 818 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation By similarity. |
| Catalytic activity | Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol. |
| Subcellular location | Nucleus By similarity. |
| Domain | Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA By similarity. |
| Sequence similarities | Belongs to the peptidase M67A family. MYSM1 subfamily. Contains 1 MPN (JAB/Mov34) domain. Contains 1 SANT domain. Contains 1 SWIRM domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 818 | 818 | Histone H2A deubiquitinase MYSM1 | PRO_0000373926 | |||||
Regions | |||||||||
| Domain | 107 – 158 | 52 | SANT | ||||||
| Domain | 344 – 442 | 99 | SWIRM | ||||||
| Domain | 543 – 653 | 111 | MPN | ||||||
| Motif | 627 – 640 | 14 | JAMM motif | ||||||
| Motif | 745 – 749 | 5 | LXXLL motif | ||||||
Sites | |||||||||
| Metal binding | 627 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 629 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 640 | 1 | Zinc; catalytic By similarity | ||||||
Sequences
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References
| [1] | NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| BC125979 mRNA. Translation: AAI25980.1. | |
| RefSeq | NP_001090503.1. |
| UniGene | Xl.3062 |
3D structure databases | |
| SMR | A0JMR6. Positions 110-159, 337-442. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | M67.005. |
Genome annotation databases | |
| GeneID | 779416. |
| KEGG | xla:779416. |
Organism-specific databases | |
| CTD | 779416. |
| Xenbase | XB-FEAT-1032956. mysm1. |
Phylogenomic databases | |
| HOVERGEN | A0JMR6. |
Family and domain databases | |
| InterPro | IPR000555. Mov34_MPN_PAD1. IPR014778. Myb_DNA-bd. IPR001005. SANT_DNA-bd. IPR017884. SANT_eukarya. IPR007526. SWIRM. [Graphical view] |
| Pfam | PF01398. Mov34. 1 hit. PF00249. Myb_DNA-binding. 1 hit. PF04433. SWIRM. 1 hit. [Graphical view] |
| SMART | SM00232. JAB_MPN. 1 hit. SM00717. SANT. 1 hit. [Graphical view] |
| PROSITE | PS51293. SANT. 1 hit. PS50934. SWIRM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MYSM1_XENLA | ||||||||
| Accession | Primary (citable) accession number: A0JMR6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


