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Reviewed, UniProtKB/Swiss-Prot A0JMR6 (MYSM1_XENLA)

Last modified October 13, 2009. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histone H2A deubiquitinase MYSM1
      Short name=2A-DUB
    EC=3.1.2.15
Alternative name(s):
    Myb-like, SWIRM and MPN domain-containing protein 1
Gene names
Name: mysm1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

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Protein attributes

Sequence length818 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation By similarity.

Catalytic activity

Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.

Subcellular location

Nucleus By similarity.

Domain

Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA By similarity.

Sequence similarities

Belongs to the peptidase M67A family. MYSM1 subfamily.

Contains 1 MPN (JAB/Mov34) domain.

Contains 1 SANT domain.

Contains 1 SWIRM domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 818818Histone H2A deubiquitinase MYSM1
PRO_0000373926

Regions

Domain107 – 15852SANT
Domain344 – 44299SWIRM
Domain543 – 653111MPN
Motif627 – 64014JAMM motif
Motif745 – 7495LXXLL motif

Sites

Metal binding6271Zinc; catalytic By similarity
Metal binding6291Zinc; catalytic By similarity
Metal binding6401Zinc; catalytic By similarity

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Sequences

Sequence LengthMass (Da)Tools
A0JMR6-1 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: E60F8B915E1CEBE0

FASTA81894,084
        10         20         30         40         50         60 
MAEEAADVDI DIEGDINESS KSIYDSLNTG FAPEHYIESA WQNEEGLAPW ALDSSISEEN 

        70         80         90        100        110        120 
REAIKKMLLE EEYYLSNKPL AVKFWSDSQE GEKQCIKRVR SPAKASSSPV KWTKEEKNLF 

       130        140        150        160        170        180 
EQGLATFGRR WTSIARLIGS RSVLQVKNYA RHYFKNKCKL EGFVKEEAKI GSLQIPNLQD 

       190        200        210        220        230        240 
YENEPDITDE PTTFRGRADP NLNAIKIEKL SDDEEIDITD EVDELLSNKT NLDTIIIAKT 

       250        260        270        280        290        300 
DKVKETKVET EVQQKSHSTT EHSQTDIPKL VLQQTETECL DSVNPLTCIT SPKWTLSPQQ 

       310        320        330        340        350        360 
CEEDDYDQPD VQDCLQEKCL SPHAEDLTVL CENENDSQDE DDEIKPPDQE LEIDRNFILD 

       370        380        390        400        410        420 
EEKQAIPEFF EGRQAKTPDR YLRIRNYILD QWENCKPKYL NKTSVRPGLK NCGDVNCIGR 

       430        440        450        460        470        480 
IHTYLELIGA INFGCEQAIY NRPRPVDKTK CKEGKDTLEA YKLAHRLQSM RTRKRRVRDP 

       490        500        510        520        530        540 
WGNWCDAKDL EGQTYEHLSA EELARRHEDK IKSYKYSKGT RQVRSSFDPF QLIPCSAFSE 

       550        560        570        580        590        600 
EKKAPFQVKV SCEAMLVLDL HAHVSMAEVI GLLGGRYTES ESVVEICAVE PCNSLSTGLQ 

       610        620        630        640        650        660 
CEMDPVSQTQ ASEALASRGY SVIGWYHSHP AFDPNPSIRD IDTQAKYQNY FSRGGAKFLG 

       670        680        690        700        710        720 
MIISPYNRRN PHPQSQVACL IISDELSNDG SYRIPYKFEI EYMQGEPQWE LVFAKTRWII 

       730        740        750        760        770        780 
EKYRSSHSSV SMDKRFRHDS ELTCLQKLLM CMKKTLGNTA CPLITEEFLH RIEEYFRTSY 

       790        800        810 
KKESNYQIED NDPCKQHSDT TFTMDSFQDY EPNGRPSL

« Hide

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

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Cross-references

Sequence databases

BC125979 mRNA. Translation: AAI25980.1.
RefSeqNP_001090503.1.
UniGeneXl.3062

3D structure databases

SMRA0JMR6. Positions 110-159, 337-442.
ModBaseSearch...

Protein family/group databases

MEROPSM67.005.

Genome annotation databases

GeneID779416.
KEGGxla:779416.

Organism-specific databases

CTD779416.
XenbaseXB-FEAT-1032956. mysm1.

Phylogenomic databases

HOVERGENA0JMR6.

Family and domain databases

InterProIPR000555. Mov34_MPN_PAD1.
IPR014778. Myb_DNA-bd.
IPR001005. SANT_DNA-bd.
IPR017884. SANT_eukarya.
IPR007526. SWIRM.
[Graphical view]
PfamPF01398. Mov34. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
SMARTSM00232. JAB_MPN. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
PROSITEPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMYSM1_XENLA
AccessionPrimary (citable) accession number: A0JMR6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: December 12, 2006
Last modified: October 13, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

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Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents