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A0JMK5

- MTMR2_DANRE

UniProt

A0JMK5 - MTMR2_DANRE

Protein

Myotubularin-related protein 2

Gene

mtmr2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei393 – 3931Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei439 – 4391SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_222631. Synthesis of PIPs at the early endosome membrane.
    REACT_223502. Synthesis of PIPs at the late endosome membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 2 (EC:3.1.3.-)
    Gene namesi
    Name:mtmr2
    ORF Names:si:dkey-110k5.3
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 5

    Organism-specific databases

    ZFINiZDB-GENE-990715-14. mtmr2.

    Subcellular locationi

    Cytoplasm. Membrane; Peripheral membrane protein
    Note: Partly associated with membranes.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 620620Myotubularin-related protein 2PRO_0000356230Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA0JMK5.

    Interactioni

    Subunit structurei

    Homooligomer and heterooligomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA0JMK5.
    SMRiA0JMK5. Positions 52-562.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 11678GRAMAdd
    BLAST
    Domaini181 – 556376Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni306 – 3094Substrate bindingBy similarity
    Regioni331 – 3322Substrate bindingBy similarity
    Regioni393 – 3997Substrate bindingBy similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili569 – 60133Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GRAM domain.Curated
    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG322789.
    GeneTreeiENSGT00670000097670.
    HOGENOMiHOG000210598.
    HOVERGENiHBG000220.
    InParanoidiA0JMK5.
    KOiK18081.
    OMAiPENGWKV.
    OrthoDBiEOG7XDBF9.
    PhylomeDBiA0JMK5.
    TreeFamiTF315197.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR004182. GRAM.
    IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PfamiPF02893. GRAM. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view]
    SMARTiSM00568. GRAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JMK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEESASVDSV ESLCSSTTTR SDRSSGPKVS DTELRSKGRP IEKMYKDPSK    50
    GELPLLPVEL VQESAKDVTY ICPFIGPIRG SLTVTNYRLF FRCTDREPVF 100
    GLDLPLGVLS RVEKIGAATG RGDVSYGLAC KDMRNLRFVH KEPDDSLKKS 150
    VFEVLMKFAF PVSNNMSLFA FEYKQVFPEN GWKVYDPLAE CKRQGLPNES 200
    WRISKLNDHY ELCDSYPATL VVPVTITDDE LRRVSSFRAK GRIPVLSWIH 250
    PESQAAVVRS SQPMVGQNGR RCKEDEKLLQ AIMDANAQSH KLFIFDARPS 300
    VNAAANKMKG GGFESEDAYQ NAELVFLDIH NIHVMRESLR KLKEVVYPNI 350
    EESHWLSNLE STHWLEHIKL ILAGALRIAD KVESGKTSVV VHCSDGWDRT 400
    AQLTSLALIM LDSHYRTIRG FQILVEKEWL SFGHRFQQRV GHGDKNHTDV 450
    DRSPIFLQFI DCVWQMTRQF PAAFEFNEYF LITILDHLYS CLFGTFLCNS 500
    EQQRLKEEIP KRTVSLWSFV NSQLEEFVNP LYVHYSSHVL FPTVGIRHLQ 550
    LWVSYYIRWN PRMRPQEPVH QRYKELLAKR AELQKRVEEL QREVSSRTAS 600
    SSSERAGSPT RSITPVQTFV 620
    Length:620
    Mass (Da):71,109
    Last modified:December 16, 2008 - v2
    Checksum:iA67ADEE5D7B27C1F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291V → L in AAI25913. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL929305 Genomic DNA. Translation: CAQ13290.1.
    BC125912 mRNA. Translation: AAI25913.1.
    RefSeqiNP_571446.1. NM_131371.1.
    UniGeneiDr.81275.

    Genome annotation databases

    EnsembliENSDART00000020004; ENSDARP00000007407; ENSDARG00000004616.
    GeneIDi30644.
    KEGGidre:30644.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL929305 Genomic DNA. Translation: CAQ13290.1 .
    BC125912 mRNA. Translation: AAI25913.1 .
    RefSeqi NP_571446.1. NM_131371.1.
    UniGenei Dr.81275.

    3D structure databases

    ProteinModelPortali A0JMK5.
    SMRi A0JMK5. Positions 52-562.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000020004 ; ENSDARP00000007407 ; ENSDARG00000004616 .
    GeneIDi 30644.
    KEGGi dre:30644.

    Organism-specific databases

    CTDi 8898.
    ZFINi ZDB-GENE-990715-14. mtmr2.

    Phylogenomic databases

    eggNOGi NOG322789.
    GeneTreei ENSGT00670000097670.
    HOGENOMi HOG000210598.
    HOVERGENi HBG000220.
    InParanoidi A0JMK5.
    KOi K18081.
    OMAi PENGWKV.
    OrthoDBi EOG7XDBF9.
    PhylomeDBi A0JMK5.
    TreeFami TF315197.

    Enzyme and pathway databases

    Reactomei REACT_222631. Synthesis of PIPs at the early endosome membrane.
    REACT_223502. Synthesis of PIPs at the late endosome membrane.

    Miscellaneous databases

    NextBioi 20807001.
    PROi A0JMK5.

    Gene expression databases

    Bgeei A0JMK5.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR004182. GRAM.
    IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    Pfami PF02893. GRAM. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SMARTi SM00568. GRAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiMTMR2_DANRE
    AccessioniPrimary (citable) accession number: A0JMK5
    Secondary accession number(s): B0R0X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3