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Protein

Myotubularin-related protein 2

Gene

mtmr2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.By similarity
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei393Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei439SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism

Enzyme and pathway databases

ReactomeiR-DRE-1483248 Synthesis of PIPs at the ER membrane
R-DRE-1660516 Synthesis of PIPs at the early endosome membrane
R-DRE-1660517 Synthesis of PIPs at the late endosome membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 2
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95By similarity)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.64By similarity)
Gene namesi
Name:mtmr2
ORF Names:si:dkey-110k5.3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-990715-14 mtmr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003562301 – 620Myotubularin-related protein 2Add BLAST620

Proteomic databases

PaxDbiA0JMK5
PeptideAtlasiA0JMK5

Expressioni

Gene expression databases

BgeeiENSDARG00000004616

Interactioni

Subunit structurei

Homooligomer and heterooligomer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000007407

Structurei

3D structure databases

ProteinModelPortaliA0JMK5
SMRiA0JMK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 116GRAMAdd BLAST78
Domaini181 – 556Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST376

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni306 – 309Substrate bindingBy similarity4
Regioni331 – 332Substrate bindingBy similarity2
Regioni393 – 399Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili569 – 601Sequence analysisAdd BLAST33

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000210598
HOVERGENiHBG000220
InParanoidiA0JMK5
KOiK18081
OMAiPENGWKV
OrthoDBiEOG091G04DS
PhylomeDBiA0JMK5
TreeFamiTF315197

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR10807 PTHR10807, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0JMK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESASVDSV ESLCSSTTTR SDRSSGPKVS DTELRSKGRP IEKMYKDPSK
60 70 80 90 100
GELPLLPVEL VQESAKDVTY ICPFIGPIRG SLTVTNYRLF FRCTDREPVF
110 120 130 140 150
GLDLPLGVLS RVEKIGAATG RGDVSYGLAC KDMRNLRFVH KEPDDSLKKS
160 170 180 190 200
VFEVLMKFAF PVSNNMSLFA FEYKQVFPEN GWKVYDPLAE CKRQGLPNES
210 220 230 240 250
WRISKLNDHY ELCDSYPATL VVPVTITDDE LRRVSSFRAK GRIPVLSWIH
260 270 280 290 300
PESQAAVVRS SQPMVGQNGR RCKEDEKLLQ AIMDANAQSH KLFIFDARPS
310 320 330 340 350
VNAAANKMKG GGFESEDAYQ NAELVFLDIH NIHVMRESLR KLKEVVYPNI
360 370 380 390 400
EESHWLSNLE STHWLEHIKL ILAGALRIAD KVESGKTSVV VHCSDGWDRT
410 420 430 440 450
AQLTSLALIM LDSHYRTIRG FQILVEKEWL SFGHRFQQRV GHGDKNHTDV
460 470 480 490 500
DRSPIFLQFI DCVWQMTRQF PAAFEFNEYF LITILDHLYS CLFGTFLCNS
510 520 530 540 550
EQQRLKEEIP KRTVSLWSFV NSQLEEFVNP LYVHYSSHVL FPTVGIRHLQ
560 570 580 590 600
LWVSYYIRWN PRMRPQEPVH QRYKELLAKR AELQKRVEEL QREVSSRTAS
610 620
SSSERAGSPT RSITPVQTFV
Length:620
Mass (Da):71,109
Last modified:December 16, 2008 - v2
Checksum:iA67ADEE5D7B27C1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29V → L in AAI25913 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929305 Genomic DNA Translation: CAQ13290.1
BC125912 mRNA Translation: AAI25913.1
RefSeqiNP_571446.1, NM_131371.1
UniGeneiDr.81275

Genome annotation databases

EnsembliENSDART00000020004; ENSDARP00000007407; ENSDARG00000004616
GeneIDi30644
KEGGidre:30644

Similar proteinsi

Entry informationi

Entry nameiMTMR2_DANRE
AccessioniPrimary (citable) accession number: A0JMK5
Secondary accession number(s): B0R0X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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