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Protein

Transcription factor RFX3

Gene

rfx3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi189 – 26476RFX-type winged-helixPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor RFX3
Alternative name(s):
Regulatory factor X 3
Gene namesi
Name:rfx3
ORF Names:zgc:153245
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-061103-253. rfx3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Transcription factor RFX3PRO_0000392995Add
BLAST

Proteomic databases

PaxDbiA0JMF8.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000041235.

Structurei

3D structure databases

ProteinModelPortaliA0JMF8.
SMRiA0JMF8. Positions 190-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RFX family.PROSITE-ProRule annotation
Contains 1 RFX-type winged-helix DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3712. Eukaryota.
ENOG410XSHE. LUCA.
HOGENOMiHOG000294091.
HOVERGENiHBG002753.
InParanoidiA0JMF8.
KOiK09173.
PhylomeDBiA0JMF8.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003150. DNA-bd_RFX.
IPR007668. RFX1_trans_act.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04589. RFX1_trans_act. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51526. RFX_DBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JMF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTPEAGADS TVSTVPLQTS VPVQPAVSGQ QVASQVPVQQ QAQTVQQVQH
60 70 80 90 100
VYQAQVQYVQ EENNSVYTNG TIRAYSYSEP QLYNQNSSGN YFDTQGGGGS
110 120 130 140 150
AAQVSTVVST HSMANNGNGT GALAMGLTGG QIISSSGAYL IGGNSMDGSA
160 170 180 190 200
PHGAAQTTRA SPATIEMAIE TLQKSEGLSS QRSSLLNSHL QWLLDNYETA
210 220 230 240 250
EGVSLPRSTL YNHYLRHCQE QKLDPVNAAS FGKLIRSIFM GLRTRRLGTR
260 270 280 290 300
GNSKYHYYGI RVKPDSPLNR LQEDMQYMAL RQQPVQQKQR FKPVQKMDGV
310 320 330 340 350
SGDNFSSAGQ HTPSAAEQTF IAQSQHHQQF LDGSRALPEF VELDLGEAVD
360 370 380 390 400
GVGPEDVKAL QTLYREHCEA ILDVVVNLQF NLIENLWQTF WRYSASSSVE
410 420 430 440 450
GVTITENSGL SEIEGRLPRA RLILLCRHEA VHKWMNTCDH LMYQALVEIL
460 470 480 490 500
IPDVLRPIPS ALTQAIRNFA KSLEGWLTNA MSSIPPRMIN TKVSAVSAFA
510 520 530 540 550
QTLRRYTSLN HLAQAARAVL QNTSQINQML SDLNRVDFAN VQEQASWVCQ
560 570 580 590 600
CEEGVVQRLE QDFKATLQQQ SSLEQWAAWL DNVVTQILKP YEDKPTLPKA
610 620 630 640 650
ARQFLLKWSF YSSMVIRDLT LRSAASFGSF HLIRLLYDEY MFYLVEHRVA
660 670 680 690 700
QATGETAIGV MGEFQDLNTM SPANIDKDEV SEMDSDLDEE MEEADEPLAK
710 720 730 740 750
REKVEADVIQ VLQVGAMEDG SSAVVGIVQP SMINSLPPTT NNHSEHILST
760
GTSTIRHVGN TYASV
Length:765
Mass (Da):84,548
Last modified:December 12, 2006 - v1
Checksum:i8F2D57190FA0BE3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125862 mRNA. Translation: AAI25863.1.
RefSeqiNP_001073517.1. NM_001080048.1.
UniGeneiDr.90095.

Genome annotation databases

GeneIDi570989.
KEGGidre:570989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125862 mRNA. Translation: AAI25863.1.
RefSeqiNP_001073517.1. NM_001080048.1.
UniGeneiDr.90095.

3D structure databases

ProteinModelPortaliA0JMF8.
SMRiA0JMF8. Positions 190-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000041235.

Proteomic databases

PaxDbiA0JMF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi570989.
KEGGidre:570989.

Organism-specific databases

CTDi5991.
ZFINiZDB-GENE-061103-253. rfx3.

Phylogenomic databases

eggNOGiKOG3712. Eukaryota.
ENOG410XSHE. LUCA.
HOGENOMiHOG000294091.
HOVERGENiHBG002753.
InParanoidiA0JMF8.
KOiK09173.
PhylomeDBiA0JMF8.

Miscellaneous databases

NextBioi20890378.
PROiA0JMF8.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR003150. DNA-bd_RFX.
IPR007668. RFX1_trans_act.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04589. RFX1_trans_act. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51526. RFX_DBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiRFX3_DANRE
AccessioniPrimary (citable) accession number: A0JMF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: December 12, 2006
Last modified: May 11, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.