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Protein

Transcription factor RFX3

Gene

rfx3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi189 – 264RFX-type winged-helixPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor RFX3
Alternative name(s):
Regulatory factor X 3
Gene namesi
Name:rfx3
ORF Names:zgc:153245
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-061103-253 rfx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003929951 – 765Transcription factor RFX3Add BLAST765

Proteomic databases

PaxDbiA0JMF8
PeptideAtlasiA0JMF8
PRIDEiA0JMF8

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000041235

Structurei

3D structure databases

ProteinModelPortaliA0JMF8
SMRiA0JMF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RFX family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3712 Eukaryota
ENOG410XSHE LUCA
HOGENOMiHOG000294091
HOVERGENiHBG002753
InParanoidiA0JMF8
KOiK09173
PhylomeDBiA0JMF8

Family and domain databases

Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR003150 DNA-bd_RFX
IPR007668 RFX1_trans_act
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF04589 RFX1_trans_act, 1 hit
PF02257 RFX_DNA_binding, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51526 RFX_DBD, 1 hit

Sequencei

Sequence statusi: Complete.

A0JMF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTPEAGADS TVSTVPLQTS VPVQPAVSGQ QVASQVPVQQ QAQTVQQVQH
60 70 80 90 100
VYQAQVQYVQ EENNSVYTNG TIRAYSYSEP QLYNQNSSGN YFDTQGGGGS
110 120 130 140 150
AAQVSTVVST HSMANNGNGT GALAMGLTGG QIISSSGAYL IGGNSMDGSA
160 170 180 190 200
PHGAAQTTRA SPATIEMAIE TLQKSEGLSS QRSSLLNSHL QWLLDNYETA
210 220 230 240 250
EGVSLPRSTL YNHYLRHCQE QKLDPVNAAS FGKLIRSIFM GLRTRRLGTR
260 270 280 290 300
GNSKYHYYGI RVKPDSPLNR LQEDMQYMAL RQQPVQQKQR FKPVQKMDGV
310 320 330 340 350
SGDNFSSAGQ HTPSAAEQTF IAQSQHHQQF LDGSRALPEF VELDLGEAVD
360 370 380 390 400
GVGPEDVKAL QTLYREHCEA ILDVVVNLQF NLIENLWQTF WRYSASSSVE
410 420 430 440 450
GVTITENSGL SEIEGRLPRA RLILLCRHEA VHKWMNTCDH LMYQALVEIL
460 470 480 490 500
IPDVLRPIPS ALTQAIRNFA KSLEGWLTNA MSSIPPRMIN TKVSAVSAFA
510 520 530 540 550
QTLRRYTSLN HLAQAARAVL QNTSQINQML SDLNRVDFAN VQEQASWVCQ
560 570 580 590 600
CEEGVVQRLE QDFKATLQQQ SSLEQWAAWL DNVVTQILKP YEDKPTLPKA
610 620 630 640 650
ARQFLLKWSF YSSMVIRDLT LRSAASFGSF HLIRLLYDEY MFYLVEHRVA
660 670 680 690 700
QATGETAIGV MGEFQDLNTM SPANIDKDEV SEMDSDLDEE MEEADEPLAK
710 720 730 740 750
REKVEADVIQ VLQVGAMEDG SSAVVGIVQP SMINSLPPTT NNHSEHILST
760
GTSTIRHVGN TYASV
Length:765
Mass (Da):84,548
Last modified:December 12, 2006 - v1
Checksum:i8F2D57190FA0BE3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125862 mRNA Translation: AAI25863.1
RefSeqiNP_001073517.1, NM_001080048.1
UniGeneiDr.90095

Genome annotation databases

GeneIDi570989
KEGGidre:570989

Similar proteinsi

Entry informationi

Entry nameiRFX3_DANRE
AccessioniPrimary (citable) accession number: A0JMF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome