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Protein

Mediator of RNA polymerase II transcription subunit 19

Gene

MED19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 19
Alternative name(s):
Lung cancer metastasis-related protein 1
Mediator complex subunit 19
Gene namesi
Name:MED19
Synonyms:LCMR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000156603.14
HGNCiHGNC:29600 MED19
MIMi612385 gene
neXtProtiNX_A0JLT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi219541
PharmGKBiPA134926032

Polymorphism and mutation databases

BioMutaiMED19

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003047661 – 244Mediator of RNA polymerase II transcription subunit 19Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA0JLT2
MaxQBiA0JLT2
PaxDbiA0JLT2
PRIDEiA0JLT2
ProteomicsDBi38
39 [A0JLT2-2]
TopDownProteomicsiA0JLT2-2 [A0JLT2-2]

PTM databases

iPTMnetiA0JLT2
PhosphoSitePlusiA0JLT2

Expressioni

Gene expression databases

BgeeiENSG00000156603
CleanExiHS_MED19
ExpressionAtlasiA0JLT2 baseline and differential
GenevisibleiA0JLT2 HS

Organism-specific databases

HPAiHPA039912
HPA040860

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MED29Q9NX708EBI-394430,EBI-394656

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128553, 55 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiA0JLT2
DIPiDIP-31467N
IntActiA0JLT2, 120 interactors
STRINGi9606.ENSP00000337340

Structurei

3D structure databases

ProteinModelPortaliA0JLT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 53Pro-richAdd BLAST40
Compositional biasi172 – 222Lys-richAdd BLAST51

Sequence similaritiesi

Belongs to the Mediator complex subunit 19 family.Curated

Phylogenomic databases

eggNOGiKOG4043 Eukaryota
ENOG4111KKA LUCA
HOGENOMiHOG000047323
HOVERGENiHBG055317
InParanoidiA0JLT2
KOiK15137
PhylomeDBiA0JLT2
TreeFamiTF317417

Family and domain databases

InterProiView protein in InterPro
IPR019403 Mediator_Med19_met
PfamiView protein in Pfam
PF10278 Med19, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0JLT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENFTALFGA QADPPPPPTA LGFGPGKPPP PPPPPAGGGP GTAPPPTAAT
60 70 80 90 100
APPGADKSGA GCGPFYLMRE LPGSTELTGS TNLITHYNLE QAYNKFCGKK
110 120 130 140 150
VKEKLSNFLP DLPGMIDLPG SHDNSSLRSL IEKPPILSSS FNPITGTMLA
160 170 180 190 200
GFRLHTGPLP EQCRLMHIQP PKKKNKHKHK QSRTQDPVPP ETPSDSDHKK
210 220 230 240
KKKKKEEDPD RKRKKKEKKK KKNRHSPDHP GMGSSQASSS SSLR
Length:244
Mass (Da):26,273
Last modified:October 2, 2007 - v2
Checksum:i9B85721364F33F02
GO
Isoform 2 (identifier: A0JLT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-194: ETPS → GKPS
     195-244: Missing.

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):20,431
Checksum:i38F9038E0795835E
GO

Sequence cautioni

The sequence AAN16075 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198H → P in AAN16075 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028121191 – 194ETPS → GKPS in isoform 2. 1 Publication4
Alternative sequenceiVSP_028122195 – 244Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA Translation: EAW73775.1
BC009723 mRNA Translation: AAH09723.1
BC037223 mRNA Translation: AAH37223.1
AY148462 mRNA Translation: AAN16075.1 Different initiation.
RefSeqiNP_001304007.1, NM_001317078.1
NP_703151.2, NM_153450.2
UniGeneiHs.43619

Genome annotation databases

EnsembliENST00000337672; ENSP00000337340; ENSG00000156603
GeneIDi219541
KEGGihsa:219541
UCSCiuc001nlb.4 human [A0JLT2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiMED19_HUMAN
AccessioniPrimary (citable) accession number: A0JLT2
Secondary accession number(s): Q8IV02, Q8IZD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 20, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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