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Protein

Inositol-tetrakisphosphate 1-kinase 5

Gene

ITPK5

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and participates in phytic acid biosynthesis in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.By similarity

Catalytic activityi

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.Curated
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.Curated
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.Curated

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei251D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei671D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei102ATPBy similarity1
Binding sitei154ATPBy similarity1
Binding sitei1651D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei1971D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei212ATPBy similarity1
Metal bindingi283Magnesium 1By similarity1
Metal bindingi298Magnesium 1By similarity1
Metal bindingi298Magnesium 2By similarity1
Metal bindingi300Magnesium 2By similarity1
Binding sitei3001D-myo-inositol 1,3,4-trisphosphateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi186 – 197ATPBy similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-tetrakisphosphate 1-kinase 5Curated (EC:2.7.1.134Curated)
Alternative name(s):
Inositol 1,3,4-trisphosphate 5/6-kinase 5Curated (EC:2.7.1.159Curated)
Short name:
Inositol-triphosphate 5/6-kinase 5Curated
Short name:
Ins(1,3,4)P(3) 5/6-kinase 5Curated
Short name:
OsITP5/6K-5Curated
Short name:
OsITPK5Curated
Gene namesi
Name:ITPK5Curated
Synonyms:ipk1 Publication
ORF Names:OsI_34771Imported
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 10

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004318781 – 342Inositol-tetrakisphosphate 1-kinase 5Add BLAST342

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi39946.BGIOSGA031340-PA.

Structurei

3D structure databases

ProteinModelPortaliA0JJZ6.
SMRiA0JJZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ITPK1 family.Curated

Phylogenomic databases

eggNOGiENOG410IHA6. Eukaryota.
ENOG4110KIK. LUCA.
OrthoDBiEOG09360FFG.

Family and domain databases

InterProiView protein in InterPro
IPR008656. Inositol_tetrakis-P_1-kinase.
PANTHERiPTHR14217. PTHR14217. 1 hit.
PfamiView protein in Pfam
PF05770. Ins134_P3_kin. 1 hit.
PIRSFiPIRSF038186. ITPK. 1 hit.

Sequencei

Sequence statusi: Complete.

A0JJZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGDEPLPGD GQRRRYLIGY ALAPKKQQSF IQPSLVSRAA GRGMDLVPVD
60 70 80 90 100
PSRPLPEQGP FHLLIHKLYG EEWRGQLDAF SAAHPAVPVV DPPHAIDRLH
110 120 130 140 150
NRISMLQVVS ELDVPLHAHH HHTFGIPSQV VVYDAAALSD SGLLAALRFP
160 170 180 190 200
LIAKPLVADG TAKSHKMSLV YHREGLRKLR PPLVLQEFVN HGGVIFKVYV
210 220 230 240 250
VGAHVTCVKR RSLPDVSSDV LQDASAEGSL SFSQVSNLPN ERTAQEYYDD
260 270 280 290 300
MRLEDAIMPP TAFINDIAAA LRRALGLHLF NFDMIRDARA GDRYLVIDIN
310 320 330 340
YFPGYAKMPG YETVLTDFFW EMVHKDDDTP NLNPNPNDED VK
Length:342
Mass (Da):38,072
Last modified:December 12, 2006 - v1
Checksum:i3B99D2AB5E46FB93
GO

Sequence cautioni

The sequence EAY79626 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM410634 Genomic DNA. Translation: CAL69001.1.
CM000135 Genomic DNA. Translation: EAY79626.1. Sequence problems.

Genome annotation databases

EnsemblPlantsiBGIOSGA031340-TA; BGIOSGA031340-PA; BGIOSGA031340.
GrameneiBGIOSGA031340-TA; BGIOSGA031340-PA; BGIOSGA031340.

Similar proteinsi

Entry informationi

Entry nameiITPK5_ORYSI
AccessioniPrimary (citable) accession number: A0JJZ6
Secondary accession number(s): A2ZAJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: December 12, 2006
Last modified: August 30, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families