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A0JC51

- ZIC4_XENLA

UniProt

A0JC51 - ZIC4_XENLA

Protein

Zinc finger protein ZIC 4

Gene

zic4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    May bind to DNA By similarity. Induces neural and neural crest differentiation. Does not induce anterior neural tissue.By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri284 – 31734C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri326 – 35328C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri359 – 38325C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri389 – 41325C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44325C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. nervous system development Source: UniProtKB-KW
    2. neural crest formation Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein ZIC 41 Publication
    Short name:
    XlZic41 Publication
    Alternative name(s):
    Zinc finger protein of the cerebellum 4By similarity
    Gene namesi
    Name:zic4
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-1033019. zic4.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Zinc finger protein ZIC 4PRO_0000364029Add
    BLAST

    Expressioni

    Tissue specificityi

    At mid-gastrula stage (stage 11.5), weakly expressed in the prospective neural fold. Expressed in the neural plate border region at early neurula stage (stage 15) with strongest expression in the prospective regions of the hyoid and branchial crests. Expression in the dorsal central nervous system (CNS) continues through late neurula stage and early tail bud stages with expression strongest in the olfactory placode and expression levels increasing as development progresses. Becomes expressed in somites.1 Publication

    Developmental stagei

    Expressed zygotically. First detected at mid-gastrula stage.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliA0JC51.
    SMRiA0JC51. Positions 278-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi31 – 11585His-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GLI C2H2-type zinc-finger protein family.Sequence Analysis
    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri284 – 31734C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri326 – 35328C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri359 – 38325C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri389 – 41325C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44325C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOVERGENiHBG007135.
    KOiK09225.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0JC51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVEALGNTG MEPPFTKRNP ALRLVDLAGA HHPHHHHHPP HLPQSVTGYP    50
    GYVAHSHSMA HVHPGEFAAD SRLGPSAAFR TEHIGHPGAL KLSPAHNPHH 100
    RHHHHHHHHH HMAGHAEVAS SQTGAFGPAQ SPAGSYSSLP HPAQAICAAG 150
    RDWLIGRDVT VPVMPGLTEQ HSPSHHGMFL STTGSYHGHH TEAGSHPYFS 200
    GAPEQASHAT PGGQPLNGHI RLGLPGDMYT RSDHFSQPVT RTDHFASPSL 250
    HNYCGMNLNM NITPHHHGPG AFFRYMRQAI KQELICKWIE EDQLPKKLCS 300
    KTFSTMHELV THVTVEHVGG PEQSNHICFW EECPREGKPF KAKYKLVNHI 350
    RVHTGEKPFP CPFPGCGKVF ARSENLKIHK RTHTGEKPFK CEFEGCDRRF 400
    ANSSDRKKHS HVHTSDKPYN CKVRGCDKSY THPSSLRKHM KVHCKSPPPS 450
    SGYESSIPSL VSPSSDSGQD PGATSSQPEP PTSSQGANLS EWYVCQQGSA 500
    ASGIPTPPGN TPSPEHRKPS YSNWQATNTF 530
    Length:530
    Mass (Da):58,225
    Last modified:December 12, 2006 - v1
    Checksum:iA444BA4FB78D8040
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB259564 mRNA. Translation: BAF36750.1.
    RefSeqiNP_001121252.1. NM_001127780.1.
    UniGeneiXl.14068.

    Genome annotation databases

    GeneIDi100158334.
    KEGGixla:100158334.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB259564 mRNA. Translation: BAF36750.1 .
    RefSeqi NP_001121252.1. NM_001127780.1.
    UniGenei Xl.14068.

    3D structure databases

    ProteinModelPortali A0JC51.
    SMRi A0JC51. Positions 278-443.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100158334.
    KEGGi xla:100158334.

    Organism-specific databases

    CTDi 84107.
    Xenbasei XB-GENE-1033019. zic4.

    Phylogenomic databases

    HOVERGENi HBG007135.
    KOi K09225.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic family."
      Fujimi T.J., Mikoshiba K., Aruga J.
      Dev. Dyn. 235:3379-3386(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Neurula1 Publication.

    Entry informationi

    Entry nameiZIC4_XENLA
    AccessioniPrimary (citable) accession number: A0JC51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3