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A0JC51

- ZIC4_XENLA

UniProt

A0JC51 - ZIC4_XENLA

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Protein

Zinc finger protein ZIC 4

Gene

zic4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May bind to DNA By similarity. Induces neural and neural crest differentiation. Does not induce anterior neural tissue.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri284 – 31734C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 35328C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri359 – 38325C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41325C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44325C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. nervous system development Source: UniProtKB-KW
  2. neural crest formation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZIC 41 Publication
Short name:
XlZic41 Publication
Alternative name(s):
Zinc finger protein of the cerebellum 4By similarity
Gene namesi
Name:zic4
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1033019. zic4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Zinc finger protein ZIC 4PRO_0000364029Add
BLAST

Expressioni

Tissue specificityi

At mid-gastrula stage (stage 11.5), weakly expressed in the prospective neural fold. Expressed in the neural plate border region at early neurula stage (stage 15) with strongest expression in the prospective regions of the hyoid and branchial crests. Expression in the dorsal central nervous system (CNS) continues through late neurula stage and early tail bud stages with expression strongest in the olfactory placode and expression levels increasing as development progresses. Becomes expressed in somites.1 Publication

Developmental stagei

Expressed zygotically. First detected at mid-gastrula stage.1 Publication

Structurei

3D structure databases

ProteinModelPortaliA0JC51.
SMRiA0JC51. Positions 278-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi31 – 11585His-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the GLI C2H2-type zinc-finger protein family.Sequence Analysis
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri284 – 31734C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 35328C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri359 – 38325C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41325C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44325C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG007135.
KOiK09225.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0JC51-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVEALGNTG MEPPFTKRNP ALRLVDLAGA HHPHHHHHPP HLPQSVTGYP
60 70 80 90 100
GYVAHSHSMA HVHPGEFAAD SRLGPSAAFR TEHIGHPGAL KLSPAHNPHH
110 120 130 140 150
RHHHHHHHHH HMAGHAEVAS SQTGAFGPAQ SPAGSYSSLP HPAQAICAAG
160 170 180 190 200
RDWLIGRDVT VPVMPGLTEQ HSPSHHGMFL STTGSYHGHH TEAGSHPYFS
210 220 230 240 250
GAPEQASHAT PGGQPLNGHI RLGLPGDMYT RSDHFSQPVT RTDHFASPSL
260 270 280 290 300
HNYCGMNLNM NITPHHHGPG AFFRYMRQAI KQELICKWIE EDQLPKKLCS
310 320 330 340 350
KTFSTMHELV THVTVEHVGG PEQSNHICFW EECPREGKPF KAKYKLVNHI
360 370 380 390 400
RVHTGEKPFP CPFPGCGKVF ARSENLKIHK RTHTGEKPFK CEFEGCDRRF
410 420 430 440 450
ANSSDRKKHS HVHTSDKPYN CKVRGCDKSY THPSSLRKHM KVHCKSPPPS
460 470 480 490 500
SGYESSIPSL VSPSSDSGQD PGATSSQPEP PTSSQGANLS EWYVCQQGSA
510 520 530
ASGIPTPPGN TPSPEHRKPS YSNWQATNTF
Length:530
Mass (Da):58,225
Last modified:December 12, 2006 - v1
Checksum:iA444BA4FB78D8040
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB259564 mRNA. Translation: BAF36750.1.
RefSeqiNP_001121252.1. NM_001127780.1.
UniGeneiXl.14068.

Genome annotation databases

GeneIDi100158334.
KEGGixla:100158334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB259564 mRNA. Translation: BAF36750.1 .
RefSeqi NP_001121252.1. NM_001127780.1.
UniGenei Xl.14068.

3D structure databases

ProteinModelPortali A0JC51.
SMRi A0JC51. Positions 278-443.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100158334.
KEGGi xla:100158334.

Organism-specific databases

CTDi 84107.
Xenbasei XB-GENE-1033019. zic4.

Phylogenomic databases

HOVERGENi HBG007135.
KOi K09225.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic family."
    Fujimi T.J., Mikoshiba K., Aruga J.
    Dev. Dyn. 235:3379-3386(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Neurula1 Publication.

Entry informationi

Entry nameiZIC4_XENLA
AccessioniPrimary (citable) accession number: A0JC51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: December 12, 2006
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3