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A0JC51 (ZIC4_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein ZIC 4

Short name=XlZic4
Alternative name(s):
Zinc finger protein of the cerebellum 4
Gene names
Name:zic4
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May bind to DNA By similarity. Induces neural and neural crest differentiation. Does not induce anterior neural tissue. Ref.1

Subcellular location

Nucleus By similarity UniProtKB O73689.

Tissue specificity

At mid-gastrula stage (stage 11.5), weakly expressed in the prospective neural fold. Expressed in the neural plate border region at early neurula stage (stage 15) with strongest expression in the prospective regions of the hyoid and branchial crests. Expression in the dorsal central nervous system (CNS) continues through late neurula stage and early tail bud stages with expression strongest in the olfactory placode and expression levels increasing as development progresses. Becomes expressed in somites. Ref.1

Developmental stage

Expressed zygotically. First detected at mid-gastrula stage. Ref.1

Sequence similarities

Belongs to the GLI C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processnervous system development

Inferred from electronic annotation. Source: UniProtKB-KW

neural crest formation

Inferred from mutant phenotype Ref.1. Source: UniProtKB

   Cellular_componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Zinc finger protein ZIC 4
PRO_0000364029

Regions

Zinc finger284 – 31734C2H2-type 1; atypical
Zinc finger326 – 35328C2H2-type 2; atypical
Zinc finger359 – 38325C2H2-type 3
Zinc finger389 – 41325C2H2-type 4
Zinc finger419 – 44325C2H2-type 5
Compositional bias31 – 11585His-rich

Sequences

Sequence LengthMass (Da)Tools
A0JC51 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: A444BA4FB78D8040

FASTA53058,225
        10         20         30         40         50         60 
MSVEALGNTG MEPPFTKRNP ALRLVDLAGA HHPHHHHHPP HLPQSVTGYP GYVAHSHSMA 

        70         80         90        100        110        120 
HVHPGEFAAD SRLGPSAAFR TEHIGHPGAL KLSPAHNPHH RHHHHHHHHH HMAGHAEVAS 

       130        140        150        160        170        180 
SQTGAFGPAQ SPAGSYSSLP HPAQAICAAG RDWLIGRDVT VPVMPGLTEQ HSPSHHGMFL 

       190        200        210        220        230        240 
STTGSYHGHH TEAGSHPYFS GAPEQASHAT PGGQPLNGHI RLGLPGDMYT RSDHFSQPVT 

       250        260        270        280        290        300 
RTDHFASPSL HNYCGMNLNM NITPHHHGPG AFFRYMRQAI KQELICKWIE EDQLPKKLCS 

       310        320        330        340        350        360 
KTFSTMHELV THVTVEHVGG PEQSNHICFW EECPREGKPF KAKYKLVNHI RVHTGEKPFP 

       370        380        390        400        410        420 
CPFPGCGKVF ARSENLKIHK RTHTGEKPFK CEFEGCDRRF ANSSDRKKHS HVHTSDKPYN 

       430        440        450        460        470        480 
CKVRGCDKSY THPSSLRKHM KVHCKSPPPS SGYESSIPSL VSPSSDSGQD PGATSSQPEP 

       490        500        510        520        530 
PTSSQGANLS EWYVCQQGSA ASGIPTPPGN TPSPEHRKPS YSNWQATNTF 

« Hide

References

[1]"Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic family."
Fujimi T.J., Mikoshiba K., Aruga J.
Dev. Dyn. 235:3379-3386(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Neurula.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB259564 mRNA. Translation: BAF36750.1.
RefSeqNP_001121252.1. NM_001127780.1.
UniGeneXl.14068.

3D structure databases

ProteinModelPortalA0JC51.
SMRA0JC51. Positions 278-443.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100158334.
KEGGxla:100158334.

Organism-specific databases

CTD84107.
XenbaseXB-GENE-1033019. zic4.

Phylogenomic databases

HOVERGENHBG007135.
KOK09225.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameZIC4_XENLA
AccessionPrimary (citable) accession number: A0JC51
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: December 12, 2006
Last modified: October 16, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families