A0JC51 (ZIC4_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein ZIC 4
Short name=XlZic4

Alternative name(s):
Zinc finger protein of the cerebellum 4

Gene names

Name:

zic4

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May bind to DNA By similarity. Induces neural and neural crest differentiation. Does not induce anterior neural tissue. Ref.1
Subcellular location	Nucleus By similarity UniProtKB O73689.
Tissue specificity	At mid-gastrula stage (stage 11.5), weakly expressed in the prospective neural fold. Expressed in the neural plate border region at early neurula stage (stage 15) with strongest expression in the prospective regions of the hyoid and branchial crests. Expression in the dorsal central nervous system (CNS) continues through late neurula stage and early tail bud stages with expression strongest in the olfactory placode and expression levels increasing as development progresses. Becomes expressed in somites. Ref.1
Developmental stage	Expressed zygotically. First detected at mid-gastrula stage. Ref.1
Sequence similarities	Belongs to the GLI C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
Gene Ontology (GO)
Biological_process	nervous system development Inferred from electronic annotation. Source: UniProtKB-KW neural crest formation Inferred from mutant phenotype Ref.1. Source: UniProtKB
Cellular_component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Zinc finger protein ZIC 4		PRO_0000364029
Regions
	Zinc finger	284 – 317	34	C2H2-type 1; atypical
	Zinc finger	326 – 353	28	C2H2-type 2; atypical
	Zinc finger	359 – 383	25	C2H2-type 3
	Zinc finger	389 – 413	25	C2H2-type 4
	Zinc finger	419 – 443	25	C2H2-type 5
	Compositional bias	31 – 115	85	His-rich

Sequences

	Sequence		Length	Mass (Da)
	A0JC51 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: A444BA4FB78D8040	FASTA	530	58,225
	10 20 30 40 50 60 MSVEALGNTG MEPPFTKRNP ALRLVDLAGA HHPHHHHHPP HLPQSVTGYP GYVAHSHSMA 70 80 90 100 110 120 HVHPGEFAAD SRLGPSAAFR TEHIGHPGAL KLSPAHNPHH RHHHHHHHHH HMAGHAEVAS 130 140 150 160 170 180 SQTGAFGPAQ SPAGSYSSLP HPAQAICAAG RDWLIGRDVT VPVMPGLTEQ HSPSHHGMFL 190 200 210 220 230 240 STTGSYHGHH TEAGSHPYFS GAPEQASHAT PGGQPLNGHI RLGLPGDMYT RSDHFSQPVT 250 260 270 280 290 300 RTDHFASPSL HNYCGMNLNM NITPHHHGPG AFFRYMRQAI KQELICKWIE EDQLPKKLCS 310 320 330 340 350 360 KTFSTMHELV THVTVEHVGG PEQSNHICFW EECPREGKPF KAKYKLVNHI RVHTGEKPFP 370 380 390 400 410 420 CPFPGCGKVF ARSENLKIHK RTHTGEKPFK CEFEGCDRRF ANSSDRKKHS HVHTSDKPYN 430 440 450 460 470 480 CKVRGCDKSY THPSSLRKHM KVHCKSPPPS SGYESSIPSL VSPSSDSGQD PGATSSQPEP 490 500 510 520 530 PTSSQGANLS EWYVCQQGSA ASGIPTPPGN TPSPEHRKPS YSNWQATNTF

References

[1]

"Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic family." Fujimi T.J., Mikoshiba K., Aruga J. Dev. Dyn. 235:3379-3386(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Neurula.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB259564 mRNA. Translation: BAF36750.1.
RefSeq	NP_001121252.1. NM_001127780.1.
UniGene	Xl.14068.
3D structure databases
ProteinModelPortal	A0JC51.
SMR	A0JC51. Positions 278-443.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100158334.
KEGG	xla:100158334.
Organism-specific databases
CTD	84107.
Xenbase	XB-GENE-1033019. zic4.
Phylogenomic databases
HOVERGEN	HBG007135.
KO	K09225.
Family and domain databases
Gene3D	3.30.160.60. 4 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ZIC4_XENLA

Accession

Primary (citable) accession number: A0JC51

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	December 12, 2006
Last modified:	April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program