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Protein

Acyl-CoA-binding domain-containing protein 5

Gene

Acbd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011Acyl-CoABy similarity
Binding sitei120 – 1201Acyl-CoABy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 5
Gene namesi
Name:Acbd5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309411. Acbd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei478 – 49821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Acyl-CoA-binding domain-containing protein 5PRO_0000287380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841PhosphoserineCombined sources
Modified residuei185 – 1851PhosphoserineCombined sources
Modified residuei187 – 1871PhosphoserineCombined sources
Modified residuei191 – 1911PhosphoserineCombined sources
Modified residuei206 – 2061PhosphoserineBy similarity
Modified residuei233 – 2331PhosphoserineBy similarity
Modified residuei301 – 3011PhosphoserineBy similarity
Modified residuei403 – 4031PhosphoserineBy similarity
Modified residuei444 – 4441N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA0FKI7.
PRIDEiA0FKI7.

PTM databases

iPTMnetiA0FKI7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066254.

Structurei

3D structure databases

ProteinModelPortaliA0FKI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 13390ACBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni55 – 6410Acyl-CoA bindingBy similarity
Regioni75 – 795Acyl-CoA bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili181 – 20929Sequence analysisAdd
BLAST
Coiled coili426 – 45126Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 194Poly-Cys
Compositional biasi313 – 418106Gly-richAdd
BLAST
Compositional biasi500 – 5034Poly-Arg

Sequence similaritiesi

Belongs to the ATG37 family.Curated
Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
HOGENOMiHOG000231479.
HOVERGENiHBG106445.
InParanoidiA0FKI7.
OMAiGRGHRMQ.
OrthoDBiEOG7TJ3JP.
PhylomeDBiA0FKI7.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR016347. ACBD5.
IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PIRSFiPIRSF002412. MA_DBI. 1 hit.
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0FKI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFLSFYAGS WESWICCCCV IPVDRPWDRG RRWQLEMADT RSVYETRFEA
60 70 80 90 100
AVKVIQSLPK NGSFQPTNEM MLRFYSFYKQ ATEGPCKLSR PGFWDPIGRY
110 120 130 140 150
KWDAWSSLGD MTKEEAMIAY VEEMKKIIET MPMTEKVEEL LHVIGPFYEI
160 170 180 190 200
VEDKKNSKSS DLTSDLGNVL TSSNAKAVNG KAESSDSGAE SEEEEAQEEL
210 220 230 240 250
KGAEQSGSDD KKMMTKSTDK NLEIIVTNGY KDSFAQDSDI HTDSSRSARR
260 270 280 290 300
SEDKKPTDQS SQQTGNTVLC VHQDTNEDPG EDASGVHHLT SDSDSEVYCD
310 320 330 340 350
SMEQFGQEEY YLGGDPAQHL EGSGFCEDAQ LSPGNGSIGK MQMRAVKGKG
360 370 380 390 400
EVKHGGEDGR SSSGTPHREK RGGESEDISG VRRGRGHRMP HLSEGTKGRQ
410 420 430 440 450
VGSGGDGERW GSDRGSRGSL NEQIALVLIR LQEDMQNVLQ RLHKLETLTA
460 470 480 490 500
SQAKLSWQTS NQPSSQRPSW WPFEMSPGAL AFAIIWPFIA QWLVHLYYQR

RRRKLN
Length:506
Mass (Da):56,782
Last modified:November 28, 2006 - v1
Checksum:i540778710E0606F9
GO
Isoform 2 (identifier: A0FKI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     385-385: R → RV

Show »
Length:471
Mass (Da):52,489
Checksum:i9AEB57A5EA885E3B
GO
Isoform 3 (identifier: A0FKI7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-385: R → RV

Show »
Length:507
Mass (Da):56,881
Checksum:i9BC8707F4C58CE74
GO

Sequence cautioni

The sequence AAI01875.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636Missing in isoform 2. 1 PublicationVSP_025454Add
BLAST
Alternative sequencei385 – 3851R → RV in isoform 2 and isoform 3. 2 PublicationsVSP_025455

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF026991 mRNA. Translation: ABK27611.1.
EF026992 mRNA. Translation: ABK27612.1.
BC101874 mRNA. Translation: AAI01875.1. Different initiation.
RefSeqiNP_001071103.1. NM_001077635.1. [A0FKI7-2]
XP_006254406.1. XM_006254344.1. [A0FKI7-3]
XP_006254407.1. XM_006254345.2. [A0FKI7-1]
UniGeneiRn.230065.

Genome annotation databases

GeneIDi307170.
KEGGirno:307170.
UCSCiRGD:1309411. rat. [A0FKI7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF026991 mRNA. Translation: ABK27611.1.
EF026992 mRNA. Translation: ABK27612.1.
BC101874 mRNA. Translation: AAI01875.1. Different initiation.
RefSeqiNP_001071103.1. NM_001077635.1. [A0FKI7-2]
XP_006254406.1. XM_006254344.1. [A0FKI7-3]
XP_006254407.1. XM_006254345.2. [A0FKI7-1]
UniGeneiRn.230065.

3D structure databases

ProteinModelPortaliA0FKI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066254.

PTM databases

iPTMnetiA0FKI7.

Proteomic databases

PaxDbiA0FKI7.
PRIDEiA0FKI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi307170.
KEGGirno:307170.
UCSCiRGD:1309411. rat. [A0FKI7-1]

Organism-specific databases

CTDi91452.
RGDi1309411. Acbd5.

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
HOGENOMiHOG000231479.
HOVERGENiHBG106445.
InParanoidiA0FKI7.
OMAiGRGHRMQ.
OrthoDBiEOG7TJ3JP.
PhylomeDBiA0FKI7.

Miscellaneous databases

PROiA0FKI7.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR016347. ACBD5.
IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PIRSFiPIRSF002412. MA_DBI. 1 hit.
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Quantitative MS of peroxisomes after fibrate treatment: from proteome acquisition to new aspects of cell biological function."
    Islinger M., Lueers G.H., Li K.W., Loos M., Voelkl A.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Prostate.
  3. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 202-212, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184; SER-185; SER-187 AND SER-191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiACBD5_RAT
AccessioniPrimary (citable) accession number: A0FKI7
Secondary accession number(s): A0FKI6, Q3T1K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 28, 2006
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.