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Protein

Calpain-7

Gene

CAPN7

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease.By similarity

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901PROSITE-ProRule annotation
Active sitei458 – 4581PROSITE-ProRule annotation
Active sitei478 – 4781PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-7 (EC:3.4.22.-)
Gene namesi
Name:CAPN7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Calpain-7PRO_0000270513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei95 – 951PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA0FKG7.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021370.

Structurei

3D structure databases

ProteinModelPortaliA0FKG7.
SMRiA0FKG7. Positions 684-813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini232 – 540309Calpain catalyticPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni541 – 701161Domain IIIAdd
BLAST
Regioni702 – 813112Domain NAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOVERGENiHBG036832.
InParanoidiA0FKG7.
KOiK08576.

Family and domain databases

Gene3Di1.20.58.280. 2 hits.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 2 hits.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0FKG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAAALERDA VQFARLAVQR DHEGRYSGAV FYYKEAAQAL IYAEMAGSSL
60 70 80 90 100
EHIQEKINEY LERVQALHSA VQSKSADPLK SKHQLDLERA HLLVTQAFDE
110 120 130 140 150
DEKGNVEDAI ELYTEAVDLC LKTSYETADK TLQNKLKQLA RQALDRAEAL
160 170 180 190 200
SEPLTKPLCK VKATNIKPKP PPTRTHFPLG TNPFQEGPQP FISPQSCDAQ
210 220 230 240 250
GQRYTAEEIE VLRTTSKING IEYVPFMNID LRERFAYPMP FCDRCGKLPL
260 270 280 290 300
SPKQKAMFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA
310 320 330 340 350
AYERRFTKKL ITSIIYPQNK DGESEYNPCG KYMVKLHLNG VPRKVIIDDQ
360 370 380 390 400
LPVDHKGELL CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL
410 420 430 440 450
TGWIPERIAM HSDSQTFSKD NSFRMLYQRF HKGDVLITAS TGVMTEAEGE
460 470 480 490 500
KWGLVPTHAY AVLDIREFKG LRFIQLKNPW SHLRWKGRYS ENDVKNWTPE
510 520 530 540 550
LQKYLNFDPR TPQKIDNGIF WISWDDLCQY YDVIYLSWNP GLLKESTCIH
560 570 580 590 600
STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA
610 620 630 640 650
NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH
660 670 680 690 700
TFTLVVSQYE KQNTIHYTVR VYSACSFTFS KIPSPYTVSK QINGKWSGQS
710 720 730 740 750
AGGCGNFQET HKNNPIYQFH IEKSGPLLIE LRGPRQYSVG FEVVTVSVVG
760 770 780 790 800
DPGPHGFQRK SSGDYRCGFC YLELESIPAG IYNIIPSTFL PKQEGPFFLD
810
FNSVIPIKTT QLQ
Length:813
Mass (Da):92,370
Last modified:November 28, 2006 - v1
Checksum:i386EF90B19B16256
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF026106 mRNA. Translation: ABK20170.1.
RefSeqiNP_001090912.1. NM_001097443.1.
UniGeneiSsc.58162.

Genome annotation databases

GeneIDi100037936.
KEGGissc:100037936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF026106 mRNA. Translation: ABK20170.1.
RefSeqiNP_001090912.1. NM_001097443.1.
UniGeneiSsc.58162.

3D structure databases

ProteinModelPortaliA0FKG7.
SMRiA0FKG7. Positions 684-813.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021370.

Protein family/group databases

MEROPSiC02.029.

Proteomic databases

PaxDbiA0FKG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100037936.
KEGGissc:100037936.

Organism-specific databases

CTDi23473.

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOVERGENiHBG036832.
InParanoidiA0FKG7.
KOiK08576.

Family and domain databases

Gene3Di1.20.58.280. 2 hits.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 2 hits.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAN7_PIG
AccessioniPrimary (citable) accession number: A0FKG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 28, 2006
Last modified: June 8, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.