A0FI79 (INP5E_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
72 kDa inositol polyphosphate 5-phosphatase
EC=3.1.3.36

Alternative name(s):
Phosphatidylinositol polyphosphate 5-phosphatase type IV
Phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Gene names

Name:

INPP5E

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts phosphatidylinositol-3,4,5-triphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates By similarity.
Catalytic activity	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Subcellular location	Cytoplasm › cytoskeleton › cilium axoneme By similarity. Golgi apparatus › Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Peripheral membrane protein associated with Golgi stacks By similarity.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.
Sequence similarities	Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type IV family.

Ontologies

Keywords
Biological process	Lipid metabolism
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Golgi apparatus Membrane
Domain	Repeat
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	lipid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cilium axoneme Inferred from sequence or structural similarity. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 644	644	72 kDa inositol polyphosphate 5-phosphatase		PRO_0000285674
Regions
	Repeat	10 – 13	4	1
	Repeat	15 – 18	4	2
	Repeat	28 – 31	4	3
	Repeat	39 – 42	4	4
	Repeat	55 – 58	4	5
	Repeat	69 – 71	3	6
	Repeat	72 – 74	3	7
	Repeat	75 – 78	4	8
	Repeat	121 – 124	4	9
	Repeat	169 – 172	4	10
	Repeat	183 – 185	3	11
	Repeat	190 – 193	4	12
	Repeat	236 – 239	4	13
	Region	10 – 242	233	13 X 4 AA repeats of P-X-X-P
	Compositional bias	92 – 97	6	Poly-Arg
Amino acid modifications
	Modified residue	99	1	Phosphoserine By similarity
	Modified residue	109	1	Phosphothreonine By similarity
	Modified residue	241	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0FI79 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 550C54D617898C9A	FASTA	644	70,221
	10 20 30 40 50 60 MPSKAENLRP SEPAPQPPEG RTLQGQLPGA PLAQRAGSPP DVPGSESPAL ACSTPATPSG 70 80 90 100 110 120 EDPPARAAPI APRPPARPRL ERALSLDDKG WRRRRFRGSQ EDLEARNGTS PSRGSVQSEG 130 140 150 160 170 180 PGAPAHSCSP PCLSTSLQEI PKSRGVLSSE RGSPSSGGNP LSGVASSSPN LPHRDAAVAG 190 200 210 220 230 240 SSPRLPSLLP PRPPPALSLD IASDSLRTAN KVDSDLADYK LRAQPLLVRA HSSLGPGRPR 250 260 270 280 290 300 SPLACDDCSL RSAKSSFSLL APIRSKDVRS RSYLEGSLLA SGALLGADEL ARYFPDRNVA 310 320 330 340 350 360 LFVATWNMQG QKELPPSLDE FLLPAEADYA QDLYVIGVQE GCSDRREWET RLQETLGPHY 370 380 390 400 410 420 VLLSSAAHGV LYMSLFIRRD LIWFCSEVEC STVTTRIVSQ IKTKGALGIS FTFFGTSFLF 430 440 450 460 470 480 ITSHFTSGDG KVAERLLDYT RTVQALALPR NVPDTNPYRS SAADVTTRFD EVFWFGDFNF 490 500 510 520 530 540 RLSGGRTVVD ALLCQGLVVD VPALLQHDQL IREMRKGSIF KGFQEPDIHF LPSYKFDIGK 550 560 570 580 590 600 DTYDSTSKQR TPSYTDRVLY RSRHKGDICP VSYSSCPGIK TSDHRPVYGL FRVKVRPGRD 610 620 630 640 NIPLAAGKFD RELYLLGIKR RISKEIQRQQ ALQSQNSSTI CSVS

References

[1]	"The complete CDS of the chimpanzee INPP5E homolog." Hampshire D.J., Woods C.G., Riley J.H., Inglehearn C.F. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ997811 mRNA. Translation: ABJ97675.1.
RefSeq	NP_001070981.1. NM_001077513.1.
UniGene	Ptr.6111.
3D structure databases
ProteinModelPortal	A0FI79.
ModBase	Search...
Protein-protein interaction databases
STRING	A0FI79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	748603.
KEGG	ptr:748603.
Organism-specific databases
CTD	23203.
Phylogenomic databases
eggNOG	maNOG05276.
GeneTree	ENSGT00600000084387.
HOVERGEN	HBG052132.
InParanoid	A0FI79.
OrthoDB	EOG4CVG6H.
Family and domain databases
InterPro	IPR005135. Endo/exonuclease/phosphatase. IPR000300. IPPc. [Graphical view]
KO	K01099.
Pfam	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
SMART	SM00128. IPPc. 1 hit. [Graphical view]
SUPFAM	SSF56219. Exo_endo_phos. 1 hit.
ProtoNet	Search...

Entry information

Entry name

INP5E_PANTR

Accession

Primary (citable) accession number: A0FI79

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	November 28, 2006
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program