A0FGR8 (ESYT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Extended synaptotagmin-2
Short name=E-Syt2

Alternative name(s):
Chr2Syt

Gene names

Name:	ESYT2
Synonyms:	FAM62B, KIAA1228

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	921 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role as calcium-regulated intrinsic membrane protein. Ref.1
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Widely expressed with high level in cerebellum. Ref.1
Sequence similarities	Belongs to the extended synaptotagmin family. Contains 3 C2 domains.
Sequence caution	The sequence BAA91539.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC85769.1 differs from that shown. Reason: Frameshift at position 800.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A0FGR8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A0FGR8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MTANRDAALS...RAPSPPRPGG → MTPPSRAEAG...GAGGAGGRAA

Note: No experimental confirmation available.

Isoform 4 (identifier: A0FGR8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.
     706-731: PVIGGSDKPGMEEKAQPPEAGPQGLH → SQSRSRPPASPRTSRCPSPPRSCGKG
     732-921: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: A0FGR8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-593: Missing.
     594-603: NPKRQDLEVE → MPVLPPCVLQ

Note: No experimental confirmation available.

Isoform 6 (identifier: A0FGR8-6)

The sequence of this isoform differs from the canonical sequence as follows:
     550-550: S → SNPLEFNPDVLKKTAVQRALKS

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 921

921

Extended synaptotagmin-2

PRO_0000278258

Regions

Transmembrane

128 – 148

21

Helical; Potential

Transmembrane

302 – 322

21

Helical; Potential

Domain

372 – 473

102

C2 1

Domain

523 – 617

95

C2 2

Domain

788 – 892

105

C2 3

Compositional bias

736 – 739

4

Poly-Ser

Amino acid modifications

Modified residue

691

1

Phosphoserine Ref.14

Modified residue

738

1

Phosphoserine By similarity

Modified residue

739

1

Phosphoserine Ref.14

Modified residue

743

1

Phosphoserine Ref.11 Ref.12 Ref.13 Ref.15

Modified residue

748

1

Phosphoserine Ref.14

Modified residue

755

1

Phosphoserine Ref.13 Ref.14

Modified residue

758

1

Phosphoserine Ref.12 Ref.13 Ref.14 Ref.15 Ref.17

Modified residue

761

1

Phosphoserine Ref.12 Ref.13 Ref.14 Ref.15 Ref.17

Natural variations

Alternative sequence

1 – 593

593

Missing in isoform 5.

VSP_023236

Alternative sequence

1 – 204

204

Missing in isoform 4.

VSP_023238

Alternative sequence

1 – 97

97

MTANR…PRPGG → MTPPSRAEAGVRRSRVPSEG RWRGAEPPGISASTQPASAG RAARHCGAMSGARGEGPEAG AGGAGGRAA in isoform 2.

VSP_023239

Alternative sequence

550

1

S → SNPLEFNPDVLKKTAVQRAL KS in isoform 6.

VSP_038324

Alternative sequence

594 – 603

10

NPKRQDLEVE → MPVLPPCVLQ in isoform 5.

VSP_023240

Alternative sequence

706 – 731

26

PVIGG…PQGLH → SQSRSRPPASPRTSRCPSPP RSCGKG in isoform 4.

VSP_023241

Alternative sequence

732 – 921

190

Missing in isoform 4.

VSP_023242

Natural variant

210

1

C → S.
Corresponds to variant rs13233513 [ dbSNP | Ensembl ].

VAR_030725

Natural variant

638

1

S → G. Ref.3
Corresponds to variant rs2305473 [ dbSNP | Ensembl ].

VAR_030726

Experimental info

Sequence conflict

141

1

L → V in CAH10642. Ref.7

Sequence conflict

612

1

S → P in BAC85769. Ref.3

Sequence conflict

615

1

N → S in BAC86489. Ref.3

Sequence conflict

795

1

R → Q in BAC85769. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

921

Helix Strand Turn

Details...

Beta strand

789 – 797

9

Turn

798 – 801

4

Beta strand

802 – 811

10

Beta strand

823 – 831

9

Beta strand

835 – 837

3

Beta strand

851 – 858

8

Helix

862 – 867

6

Beta strand

869 – 876

8

Beta strand

889 – 894

6

Turn

899 – 902

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: D57F1BD9BB0A0C8A	FASTA	921	102,357
	10 20 30 40 50 60 MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS HAPGSRLGAR 70 80 90 100 110 120 RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN PGGVLSVELP GLLAQLARSF 130 140 150 160 170 180 ALLLPVYALG YLGLSFSWVL LALALLAWCR RSRGLKALRL CRALALLEDE ERVVRLGVRA 190 200 210 220 230 240 CDLPAWVHFP DTERAEWLNK TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV 250 260 270 280 290 300 DVGQQPLRIN GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM 310 320 330 340 350 360 RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI ILDIISNYLV 370 380 390 400 410 420 LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK DTYLKGLVKG KSDPYGIIRV 430 440 450 460 470 480 GNQIFQSRVI KENLSPKWNE VYEALVYEHP GQELEIELFD EDPDKDDFLG SLMIDLIEVE 490 500 510 520 530 540 KERLLDEWFT LDEVPKGKLH LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL 550 560 570 580 590 600 YLDSARNLPS GKKISSNPNP VVQMSVGHKA QESKIRYKTN EPVWEENFTF FIHNPKRQDL 610 620 630 640 650 660 EVEVRDEQHQ CSLGNLKVPL SQLLTSEDMT VSQRFQLSNS GPNSTIKMKI ALRVLHLEKR 670 680 690 700 710 720 ERPPDHQHSA QVKRPSVSKE GRKTSIKSHM SGSPGPGGSN TAPSTPVIGG SDKPGMEEKA 730 740 750 760 770 780 QPPEAGPQGL HDLGRSSSSL LASPGHISVK EPTPSIASDI SLPIATQELR QRLRQLENGT 790 800 810 820 830 840 TLGQSPLGQI QLTIRHSSQR NKLIVVVHAC RNLIAFSEDG SDPYVRMYLL PDKRRSGRRK 850 860 870 880 890 900 THVSKKTLNP VFDQSFDFSV SLPEVQRRTL DVAVKNSGGF LSKDKGLLGK VLVALASEEL 910 920 AKGWTQWYDL TEDGTRPQAM T
	Isoform 2 [UniParc]. Checksum: 9C059B137A2F1EFB	FASTA	893	98,902
	10 20 30 40 50 60 MTPPSRAEAG VRRSRVPSEG RWRGAEPPGI SASTQPASAG RAARHCGAMS GARGEGPEAG 70 80 90 100 110 120 AGGAGGRAAP ENPGGVLSVE LPGLLAQLAR SFALLLPVYA LGYLGLSFSW VLLALALLAW 130 140 150 160 170 180 CRRSRGLKAL RLCRALALLE DEERVVRLGV RACDLPAWVH FPDTERAEWL NKTVKHMWPF 190 200 210 220 230 240 ICQFIEKLFR ETIEPAVRGA NTHLSTFSFT KVDVGQQPLR INGVKVYTEN VDKRQIILDL 250 260 270 280 290 300 QISFVGNCEI DLEIKRYFCR AGVKSIQIHG TMRVILEPLI GDMPLVGALS IFFLRKPLLE 310 320 330 340 350 360 INWTGLTNLL DVPGLNGLSD TIILDIISNY LVLPNRITVP LVSEVQIAQL RFPVPKGVLR 370 380 390 400 410 420 IHFIEAQDLQ GKDTYLKGLV KGKSDPYGII RVGNQIFQSR VIKENLSPKW NEVYEALVYE 430 440 450 460 470 480 HPGQELEIEL FDEDPDKDDF LGSLMIDLIE VEKERLLDEW FTLDEVPKGK LHLRLEWLTL 490 500 510 520 530 540 MPNASNLDKV LTDIKADKDQ ANDGLSSALL ILYLDSARNL PSGKKISSNP NPVVQMSVGH 550 560 570 580 590 600 KAQESKIRYK TNEPVWEENF TFFIHNPKRQ DLEVEVRDEQ HQCSLGNLKV PLSQLLTSED 610 620 630 640 650 660 MTVSQRFQLS NSGPNSTIKM KIALRVLHLE KRERPPDHQH SAQVKRPSVS KEGRKTSIKS 670 680 690 700 710 720 HMSGSPGPGG SNTAPSTPVI GGSDKPGMEE KAQPPEAGPQ GLHDLGRSSS SLLASPGHIS 730 740 750 760 770 780 VKEPTPSIAS DISLPIATQE LRQRLRQLEN GTTLGQSPLG QIQLTIRHSS QRNKLIVVVH 790 800 810 820 830 840 ACRNLIAFSE DGSDPYVRMY LLPDKRRSGR RKTHVSKKTL NPVFDQSFDF SVSLPEVQRR 850 860 870 880 890 TLDVAVKNSG GFLSKDKGLL GKVLVALASE ELAKGWTQWY DLTEDGTRPQ AMT
	Isoform 4 [UniParc]. Checksum: E4257349511C9C28	FASTA	527	59,403
	10 20 30 40 50 60 MWPFICQFIE KLFRETIEPA VRGANTHLST FSFTKVDVGQ QPLRINGVKV YTENVDKRQI 70 80 90 100 110 120 ILDLQISFVG NCEIDLEIKR YFCRAGVKSI QIHGTMRVIL EPLIGDMPLV GALSIFFLRK 130 140 150 160 170 180 PLLEINWTGL TNLLDVPGLN GLSDTIILDI ISNYLVLPNR ITVPLVSEVQ IAQLRFPVPK 190 200 210 220 230 240 GVLRIHFIEA QDLQGKDTYL KGLVKGKSDP YGIIRVGNQI FQSRVIKENL SPKWNEVYEA 250 260 270 280 290 300 LVYEHPGQEL EIELFDEDPD KDDFLGSLMI DLIEVEKERL LDEWFTLDEV PKGKLHLRLE 310 320 330 340 350 360 WLTLMPNASN LDKVLTDIKA DKDQANDGLS SALLILYLDS ARNLPSGKKI SSNPNPVVQM 370 380 390 400 410 420 SVGHKAQESK IRYKTNEPVW EENFTFFIHN PKRQDLEVEV RDEQHQCSLG NLKVPLSQLL 430 440 450 460 470 480 TSEDMTVSQR FQLSNSGPNS TIKMKIALRV LHLEKRERPP DHQHSAQVKR PSVSKEGRKT 490 500 510 520 SIKSHMSGSP GPGGSNTAPS TSQSRSRPPA SPRTSRCPSP PRSCGKG
	Isoform 5 [UniParc]. Checksum: EF531CFF2A35D17C	FASTA	328	35,846
	10 20 30 40 50 60 MPVLPPCVLQ VRDEQHQCSL GNLKVPLSQL LTSEDMTVSQ RFQLSNSGPN STIKMKIALR 70 80 90 100 110 120 VLHLEKRERP PDHQHSAQVK RPSVSKEGRK TSIKSHMSGS PGPGGSNTAP STPVIGGSDK 130 140 150 160 170 180 PGMEEKAQPP EAGPQGLHDL GRSSSSLLAS PGHISVKEPT PSIASDISLP IATQELRQRL 190 200 210 220 230 240 RQLENGTTLG QSPLGQIQLT IRHSSQRNKL IVVVHACRNL IAFSEDGSDP YVRMYLLPDK 250 260 270 280 290 300 RRSGRRKTHV SKKTLNPVFD QSFDFSVSLP EVQRRTLDVA VKNSGGFLSK DKGLLGKVLV 310 320 ALASEELAKG WTQWYDLTED GTRPQAMT
	Isoform 6 [UniParc]. Checksum: 207D6C010DB58248	FASTA	942	104,708
	10 20 30 40 50 60 MTANRDAALS SHRHPGCAQR PRTPTFASSS QRRSAFGFDD GNFPGLGERS HAPGSRLGAR 70 80 90 100 110 120 RRAKTARGLR GHRQRGAGAG LSRPGSARAP SPPRPGGPEN PGGVLSVELP GLLAQLARSF 130 140 150 160 170 180 ALLLPVYALG YLGLSFSWVL LALALLAWCR RSRGLKALRL CRALALLEDE ERVVRLGVRA 190 200 210 220 230 240 CDLPAWVHFP DTERAEWLNK TVKHMWPFIC QFIEKLFRET IEPAVRGANT HLSTFSFTKV 250 260 270 280 290 300 DVGQQPLRIN GVKVYTENVD KRQIILDLQI SFVGNCEIDL EIKRYFCRAG VKSIQIHGTM 310 320 330 340 350 360 RVILEPLIGD MPLVGALSIF FLRKPLLEIN WTGLTNLLDV PGLNGLSDTI ILDIISNYLV 370 380 390 400 410 420 LPNRITVPLV SEVQIAQLRF PVPKGVLRIH FIEAQDLQGK DTYLKGLVKG KSDPYGIIRV 430 440 450 460 470 480 GNQIFQSRVI KENLSPKWNE VYEALVYEHP GQELEIELFD EDPDKDDFLG SLMIDLIEVE 490 500 510 520 530 540 KERLLDEWFT LDEVPKGKLH LRLEWLTLMP NASNLDKVLT DIKADKDQAN DGLSSALLIL 550 560 570 580 590 600 YLDSARNLPS NPLEFNPDVL KKTAVQRALK SGKKISSNPN PVVQMSVGHK AQESKIRYKT 610 620 630 640 650 660 NEPVWEENFT FFIHNPKRQD LEVEVRDEQH QCSLGNLKVP LSQLLTSEDM TVSQRFQLSN 670 680 690 700 710 720 SGPNSTIKMK IALRVLHLEK RERPPDHQHS AQVKRPSVSK EGRKTSIKSH MSGSPGPGGS 730 740 750 760 770 780 NTAPSTPVIG GSDKPGMEEK AQPPEAGPQG LHDLGRSSSS LLASPGHISV KEPTPSIASD 790 800 810 820 830 840 ISLPIATQEL RQRLRQLENG TTLGQSPLGQ IQLTIRHSSQ RNKLIVVVHA CRNLIAFSED 850 860 870 880 890 900 GSDPYVRMYL LPDKRRSGRR KTHVSKKTLN PVFDQSFDFS VSLPEVQRRT LDVAVKNSGG 910 920 930 940 FLSKDKGLLG KVLVALASEE LAKGWTQWYD LTEDGTRPQA MT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains." Min S.-W., Chang W.-P., Suedhof T.C. Proc. Natl. Acad. Sci. U.S.A. 104:3823-3828(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	Shan Y.X., Yu L. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 511-921 (ISOFORMS 1/2), VARIANT GLY-638. Tissue: Esophageal carcinoma and Thymus.
[4]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-921 (ISOFORM 1). Tissue: Brain.
[6]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-921. Tissue: Melanoma.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 454-921 (ISOFORM 6). Tissue: Colon.
[9]	"Genomic analysis of synaptotagmin genes." Craxton M.A. Genomics 77:43-49(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 747-904. Tissue: Brain.
[10]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-743, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-743; SER-758 AND SER-761, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-743; SER-755; SER-758 AND SER-761, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-691; SER-739; SER-748; SER-755; SER-758 AND SER-761, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[15]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-743; SER-758 AND SER-761, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-758 AND SER-761, MASS SPECTROMETRY.
[18]	"Solution structure of the third C2 domain of KIAA1228 protein." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 222-350.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DQ993201 mRNA. Translation: ABJ97706.1.
AY368150 mRNA. Translation: AAR89381.1.
AK001181 mRNA. Translation: BAA91539.1. Different initiation.
AK124091 mRNA. Translation: BAC85769.1. Frameshift.
AK126214 mRNA. Translation: BAC86489.1.
CH236954 Genomic DNA. Translation: EAL23931.1.
AB033054 mRNA. Translation: BAA86542.2.
AL833233 mRNA. Translation: CAH10642.1.
BC013957 mRNA. Translation: AAH13957.2.
AJ303365 mRNA. Translation: CAC33887.1.

IPI

IPI00409635.
IPI00827663.
IPI00827794.
IPI00827920.
IPI00953221.

RefSeq

NP_065779.1. NM_020728.2.

UniGene

Hs.490795.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DMG	NMR	-	A	785-913	[»]

ProteinModelPortal

A0FGR8.

ModBase

Search...

Protein-protein interaction databases

IntAct

A0FGR8. 5 interactions.

MINT

MINT-4541681.

PTM databases

PhosphoSite

A0FGR8.

Proteomic databases

PaxDb

A0FGR8.

PRIDE

A0FGR8.

Protocols and materials databases

DNASU

57488.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000251527; ENSP00000251527; ENSG00000117868.

GeneID

57488.

KEGG

hsa:57488.

UCSC

uc003woa.1. human.
uc003woc.1. human.

Organism-specific databases

CTD

57488.

GeneCards

GC07M158523.

H-InvDB

HIX0007266.

HGNC

HGNC:22211. ESYT2.

HPA

HPA002132.

neXtProt

NX_A0FGR8.

PharmGKB

PA165617947.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5038.

HOVERGEN

HBG055795.

InParanoid

A0FGR8.

Gene expression databases

ArrayExpress

A0FGR8.

Bgee

A0FGR8.

CleanEx

HS_FAM62B.

Genevestigator

A0FGR8.

Family and domain databases

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
[Graphical view]

Pfam

PF00168. C2. 3 hits.
[Graphical view]

SMART

SM00239. C2. 3 hits.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 3 hits.

PROSITE

PS50004. C2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

ESYT2. human.

EvolutionaryTrace

A0FGR8.

GenomeRNAi

57488.

NextBio

63768.

Entry information

Entry name

ESYT2_HUMAN

Accession

Primary (citable) accession number: A0FGR8
Secondary accession number(s): A4D229 , Q69YJ2, Q6UKI4, Q6ZTU0, Q6ZVU1, Q9BQS0, Q9NW47, Q9ULJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	November 28, 2006
Last modified:	May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.