Unreviewed, UniProtKB/TrEMBL A0EKU7 (A0EKU7_9FLAV)

Names and origin

Protein names	Submitted name: Polyprotein EMBL ABB90674.1
Organism	Saumarez Reef virus EMBL ABB90674.1
Taxonomic identifier	40012 [NCBI]
Taxonomic lineage	Viruses › ssRNA positive-strand viruses, no DNA stage › Flaviviridae › Flavivirus › Seaborne tick-borne virus group

Protein attributes

Sequence length	3422 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	NTP + H2O = NDP + phosphate. Spearmint SPM007094
Sequence similarities	Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Biological process	RNA replication Spearmint SPM007094
Cellular component	Capsid protein Spearmint SPM011998 Envelope protein Spearmint SPM000336 Host membrane Spearmint SPM011998 Membrane Virion
Domain	Transmembrane Spearmint SPM000336
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Spearmint SPM007094 Hydrolase
Gene Ontology (GO)
Biological process	cellular RNA metabolic process Inferred from electronic annotation. Source: InterPro cellular transcription, RNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW methylation Inferred from electronic annotation. Source: InterPro viral genome replication Inferred from electronic annotation. Source: InterPro
Cellular component	host cell membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral capsid Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA helicase activity Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: InterPro double-stranded RNA binding Inferred from electronic annotation. Source: InterPro methyltransferase activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0EKU7-1 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 4156D504D9D53CC2	FASTA	3,422	379,688
	10 20 30 40 50 60 MPSILKKGGG KPTAKAVKTA KKNNGKKLVT MPRKLAITAM IRVILMMAQG VARPLDLRRF 70 80 90 100 110 120 MRFTPVVQLR AVLKRIQRIV RSLLIEISGR NRRGPGGMRW MILLPLIGGC MGALVMTRLD 130 140 150 160 170 180 GILVKVEPKD VGTAARIGNG TCTFLMTDVG DWCEDNIEYP CVTIEPNESP VDIDCYCRGV 190 200 210 220 230 240 EDVRVTFGLC SREEKRSRAR RSISITPHGV ASEHSRKGTW LDTDRGMQHV TRVESWVLKN 250 260 270 280 290 300 KLFAAAVILA AWALGRTTTQ RVLLIAGALL VVPAYASKCV HLENRDIVTG TTGTSRVNVV 310 320 330 340 350 360 LEKHACVTIV ADGKPSIDIW LDGIYQESPA KTREYCLSME LSNQKIDARC PSMGEAYLEE 370 380 390 400 410 420 ENSRDNVCHR DYSDRGWGNH CGLFGKGSIV GCVKVTCTSG KTLQGLEFDA NKITYAVHLE 430 440 450 460 470 480 VHDGVMRTLN NLNTLRKTSL FTAASEKHVV SINQFGQATI QCRVNSGIDL AKTMLVQMGD 490 500 510 520 530 540 DVWSVHRDWF EDLPYPWRHG GTSWREVSRV VGFEPPHAVK MTAHSLGDQT GAVLKALSGA 550 560 570 580 590 600 NKGMKTSNKY EISGGHVSCV VGLEGLKIRG LTYTLCGGND FTWKKNPTES QHDTVVMEVT 610 620 630 640 650 660 YTGSSTPCRV PVRAYHPTIV EKDIASIITA NPVVESTHTK DVFIEMQLPP GDSIIAIGSL 670 680 690 700 710 720 RYQWFQKGST IGRMATLTAK GIRRMAILGE TAWDFGSAGG FFTSVGRGIH MALGGVFNAI 730 740 750 760 770 780 FGGVGFFPRI LIGAFLVWIG LGARNMTLSM ILMATGGILL SLTLGVGADY GCAVDMSRRE 790 800 810 820 830 840 LRCGRAVAVW KETPEWFEGY QYHPESPGLL ASAIQKSMDA GICGVIPANR LEATMWRSIL 850 860 870 880 890 900 DELNLALSEA ETNTTVVVDR EGVDFRGEDR YLLKRDEKPL EVGWKAWGKS IIWSVPEGGK 910 920 930 940 950 960 RFLIGRKGTH ECPLEKRAWN TFKLAEFGVG LRTKVFMDIR EEMTRDCDTG LMGAAVKNGE 970 980 990 1000 1010 1020 AVHTDQSLWM LSSFNETLTT ITELHITDFR NCTWPATHTL NNDGVEQTKM FLPRAFAGPR 1030 1040 1050 1060 1070 1080 SRFNVIPGYS EQVKGPWNKA PLHILREPCP ETTVRVDPKC DGRGASTRST TESGKIIPEW 1090 1100 1110 1120 1130 1140 CCRSCVLPPV TFRSGTECWY AMEIRPIHQQ GGLVRSTVLA MTDGLETEGA LPGVLSLLIV 1150 1160 1170 1180 1190 1200 VELLVRRRIG TSRGILMGGA LLLVMMVLRV VTVESLVRYM VATGIVWHLQ VGPEVMNLIL 1210 1220 1230 1240 1250 1260 LQSVFELRTG FIGAFVLREE WTQRETLVVY LALVAISAGV PEGDLDVFKA LDTMALTAAL 1270 1280 1290 1300 1310 1320 VRTLGGDKRN GMAMLLIMLM SLRELEPFRV AVQLTCGVLV GTTAYQLWRG AGEQKAACRV 1330 1340 1350 1360 1370 1380 VWIAALSAAL AGSGGVGIRL LGATGLWTFF RSGRRSVADA TSVAGILLVV ASVVLRGGPP 1390 1400 1410 1420 1430 1440 EFMLAVAVGG AMLLAYIVVA RRTHLVAEWV GSIQWEHGLE NEGGKVNLRA HRDDMGNIRP 1450 1460 1470 1480 1490 1500 VREDEPGYAA VVFMTAGFFM AAYGWTGIIA VAVCWIIWEW WHNDTRRGDL VWNGLSIGGC 1510 1520 1530 1540 1550 1560 SPGGIFEVKT GVYRIYEPGL FGGRRQIGVG YGNAGVLHTM WHVSRGAAIL IGDAMQGPTW 1570 1580 1590 1600 1610 1620 ADVHRDLVSY GGDWALPKKW RGGTVQVHAF PPGRPHEVHQ TEPGTLKMED GTTEGAIHID 1630 1640 1650 1660 1670 1680 LPRGTSGSPI LDEDGVIVGL YGNGLRHGES YISSISQGDV VEKEEAPLPE AIRGREWMSK 1690 1700 1710 1720 1730 1740 GRITVLDMHP GSGKTHRVLP ELVRRCIAER KRTIVLAPTR VVLREMEKAL RGKNVRFHSD 1750 1760 1770 1780 1790 1800 SVEVRGERAI VDVMCHATYT HRRLLPTAQP NYEVAVMDEG HWTDPCSIAA RGHLSSLAGE 1810 1820 1830 1840 1850 1860 GRCAFVLMTA TPPGTMDPFP DSNERIESRE EIIPTRDWKD GFEWITDFEG RTAWFVASIR 1870 1880 1890 1900 1910 1920 EGGLIAQALR RRGKKVVCLN SKTFDKEYGS IAEEKPDFII TTDISEMGAN FGVERVIDGR 1930 1940 1950 1960 1970 1980 QNIKPIITDE RVELSEPRPV TPASAAQRRG RVGRTKGKKA EYVYHGEVEA DDSCLAQWVE 1990 2000 2010 2020 2030 2040 GQMLLDNMMS QRGTVALFYG AEQSKMPAEP GHFRLGDEAR KHFRALIVMQ DFTPWLAWNV 2050 2060 2070 2080 2090 2100 AKNTTGIIDR KWTHGGPEGN TVTGADGEAV TFRAPGGATR KLCPVWWDAR VLRAGRDLEG 2110 2120 2130 2140 2150 2160 FIRYAEGRRS IGGGMIHGLG LMPEIMAKRG EQALDVFYTL WHERAGTRAF TRAEAELPEA 2170 2180 2190 2200 2210 2220 FCTIFEFIFL GLGTCGVIWL LSARYTASRL FLGVVVMSVA GTLMWCGGFA AGQIAGMMIV 2230 2240 2250 2260 2270 2280 FYIVLVVLLP EPGTQRSFED NKLAYCVLGI LVVTGIVAAN EMGWLEKTKA DIGNVIWWKE 2290 2300 2310 2320 2330 2340 PAQEAWGVTP SALSLDIDLR PNISWGTYVA IVSICTPHLL HRIRTAVQQT VNAAVSSNGQ 2350 2360 2370 2380 2390 2400 GLRELGGGSP FFSIKRHVVA LALSSAAGST MTTFVVGVAL AVAHWTLTLT GVEAALIQRA 2410 2420 2430 2440 2450 2460 HRTYFSAMVK NPMVDGEPVN EFEREEGKPP GYERKLSIVI LLGLCLVSVL LNRQPWAIFE 2470 2480 2490 2500 2510 2520 AVALGLGGIS QWNEPARETY WTMPVVCGFV SIGRGHWLGS IPIIERLVSE SQRDRRGPGS 2530 2540 2550 2560 2570 2580 AGASLGMLWK EKLNQMDREG FHKYRRAGAM ETDRRLAREL LCKGEGKMGL AVSRGTSKLA 2590 2600 2610 2620 2630 2640 WMEEGGYVEH TGRVVDLGCG RGGWSYLAAS KTKVMEVRGY TLGIDGHEVP RLVESFGWNI 2650 2660 2670 2680 2690 2700 IKFKSKVDVF RMRPERVDTI LCDIGESSPK WQIESERTMR VLDLLEKWKA ESPAAEFVVK 2710 2720 2730 2740 2750 2760 VLCPYSAEVM ERLSAMQRRW GGGLVRNPFS RNSTHEMYYT SRAGGNIVGS VTACTERLLG 2770 2780 2790 2800 2810 2820 RMARSDGPVT VPEIDLGLGT RCVTLATDTI DRRLIQERLD RIKAQYARTW LHDENHPYRT 2830 2840 2850 2860 2870 2880 WQYWGSYRCA DTGSAASLVN GIVKMLSWPW NAREEVCLMA MTDTTAFGQQ RVFKDKVDTK 2890 2900 2910 2920 2930 2940 AQEPRIGTRI IMRTVNNWLL GKIMEKKKPR LCSREEFIAK VCSNAAIGAW LDEQNQWKDA 2950 2960 2970 2980 2990 3000 KEAVADPRFW RMVDEERELH LQGRCASCVY NMMGKREKKI GEFGKAKGSR AIWYMWLGSR 3010 3020 3030 3040 3050 3060 FLEFEALGFL NEDHWAAREI SGGGVEGTGL HYLGWLMEAL SRKEGGRMYA DDTAGWDTRI 3070 3080 3090 3100 3110 3120 TNSDLEDEEE LLNSLDEEHK KLASAVMKLA YHAKVVRVAR PASDGGTVMD IISRRDQRGS 3130 3140 3150 3160 3170 3180 GQVVTYALNT LTNIKVQLIR MMEGEGVIGP VDMDEPRVKR IERWLQEHGE ERLSRMLVSG 3190 3200 3210 3220 3230 3240 DDCVVKPIDD RFAGALYFIN DMAKIRKDVG EWTPSTGYDN WEEVPFCSHR FHRLVMKDGR 3250 3260 3270 3280 3290 3300 EIIVPCREQD ELVGRARVSP GCGWTVRETA GLSKAYAQMW LLGYFHRRDL RLMALAICSA 3310 3320 3330 3340 3350 3360 VPVDWVPTGR TTWSIHGKGE WMTTEDMLDV WNRVWIFDNP HMPEDKKERV TDWRDIPYLP 3370 3380 3390 3400 3410 3420 KTSDQACGSL VGTSTRATWA ENIWSSVEKI RKMVGNESFR NYLMVMDRYQ GGEALPVVSD II

References

[1]

"Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy." Grard G., Moureau G., Charrel R.N., Lemasson J.J., Gonzalez J.P., Gallian P., Gritsun T.S., Holmes E.C., Gould E.A., de Lamballerie X. Virology 361:80-92(2007) [PubMed: 17169393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ235150 Genomic RNA. Translation: ABB90674.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	S07.001.
Family and domain databases
InterPro	IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR000069. Env_glycoprot_M_flavivir. IPR001157. Flavi_NS1. IPR000752. Flavi_NS2A. IPR000487. Flavi_NS2B. IPR000404. Flavi_NS4A. IPR001528. Flavi_NS4B. IPR002535. Flavi_propep. IPR000336. Flv_glyE_Ig-like. IPR014412. Gen_Poly_FLV. IPR011999. GlycoprotE_cen/dimer_Flavivir. IPR011998. GlycoprotE_cen/dimer_vir. IPR014021. Helicase_SF1/SF2_ATP-bd. IPR014756. Ig_E-set. IPR001850. Peptidase_S7. IPR000208. RNA-dir_pol_flavivirus. IPR007094. RNA-dir_pol_PSvirus. IPR002877. rRNA_MeTrfase_RrmJ/FtsJ. IPR009003. Ser/Cys_Pept_Trypsin-like. [Graphical view]
Gene3D	G3DSA:2.60.40.350. Flv_glyE_Ig-like. 1 hit.
Pfam	PF02832. Flavi_glycop_C. 1 hit. PF00869. Flavi_glycoprot. 1 hit. PF01004. Flavi_M. 1 hit. PF00948. Flavi_NS1. 1 hit. PF01005. Flavi_NS2A. 1 hit. PF01002. Flavi_NS2B. 1 hit. PF01350. Flavi_NS4A. 1 hit. PF01349. Flavi_NS4B. 1 hit. PF00972. Flavi_NS5. 1 hit. PF01570. Flavi_propep. 1 hit. PF01728. FtsJ. 1 hit. PF00271. Helicase_C. 1 hit. PF00949. Peptidase_S7. 1 hit. [Graphical view]
PIRSF	PIRSF003817. Gen_Poly_FLV. 1 hit.
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit. SSF56983. Flavi_glycoprotE. 1 hit. SSF81296. Ig_E-set. 1 hit.
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50507. RDRP_SSRNA_POS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0EKU7_9FLAV

Accession

Primary (citable) accession number: A0EKU7

Entry history

Integrated into UniProtKB/TrEMBL:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	March 2, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)