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A0E358 (CATL2_PARTE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathepsin L 2

EC=3.4.22.15
Gene names
ORF Names:GSPATT00022898001
OrganismParamecium tetraurelia [Reference proteome]
Taxonomic identifier5888 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in extracellular digestion By similarity.

Catalytic activity

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the peptidase C1 family.

Sequence caution

The sequence CAK89725.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Propeptide25 – 10985Activation peptide By similarity
PRO_0000307837
Chain110 – 314205Cathepsin L 2
PRO_0000307838

Sites

Active site1351 By similarity
Active site2651 By similarity
Active site2821 By similarity

Amino acid modifications

Disulfide bond132 ↔ 175 By similarity
Disulfide bond166 ↔ 207 By similarity
Disulfide bond259 ↔ 302 By similarity

Sequences

Sequence LengthMass (Da)Tools
A0E358 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 2D580F2BB700AFD0

FASTA31434,935
        10         20         30         40         50         60 
MMLLGASLYL NNTQEVSDEI DTANLYANWK MKYNRRYTSQ RDEMYRFKVF SDNLNYIRAF 

        70         80         90        100        110        120 
QDSTESATYT LELNQFADMS QQEFASTYLS LRVPKTAKLN ASNANFQYKG AEVDWTDNKK 

       130        140        150        160        170        180 
VKYPAVKNQG SCGSCWAFSA VGALEINTDI ELNKKYELSE QDLVDCSGPY DNEGCNGGWM 

       190        200        210        220        230        240 
DSAFEYVADN GLAEAKDYPY TAKDGTCKTS VKRPYTHVQG FTDIDSCDEL AQAIQERTVS 

       250        260        270        280        290        300 
VAVDANPWQF YRSGVLSKCT KNLNHGVVLV GVQADGAWKI RNSWGSSWGE AGHIRLAGGD 

       310 
TCGICAAPSF PILG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CT868656 Genomic DNA. Translation: CAK89725.1. Different initiation.
UniGenePte.76.

3D structure databases

ProteinModelPortalA0E358.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATL2_PARTE
AccessionPrimary (citable) accession number: A0E358
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 11, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries