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A0E358

- CATL2_PARTE

UniProt

A0E358 - CATL2_PARTE

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Protein

Cathepsin L 2

Gene

GSPATT00022898001

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

May be involved in extracellular digestion.By similarity

Catalytic activityi

Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351PROSITE-ProRule annotation
Active sitei265 – 2651PROSITE-ProRule annotation
Active sitei282 – 2821PROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin L 2 (EC:3.4.22.15)
Gene namesi
ORF Names:GSPATT00022898001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600: Partially assembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 10985Activation peptideBy similarityPRO_0000307837Add
BLAST
Chaini110 – 314205Cathepsin L 2PRO_0000307838Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi132 ↔ 175By similarity
Disulfide bondi166 ↔ 207By similarity
Disulfide bondi259 ↔ 302By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliA0E358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiA0E358.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0E358-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLLGASLYL NNTQEVSDEI DTANLYANWK MKYNRRYTSQ RDEMYRFKVF
60 70 80 90 100
SDNLNYIRAF QDSTESATYT LELNQFADMS QQEFASTYLS LRVPKTAKLN
110 120 130 140 150
ASNANFQYKG AEVDWTDNKK VKYPAVKNQG SCGSCWAFSA VGALEINTDI
160 170 180 190 200
ELNKKYELSE QDLVDCSGPY DNEGCNGGWM DSAFEYVADN GLAEAKDYPY
210 220 230 240 250
TAKDGTCKTS VKRPYTHVQG FTDIDSCDEL AQAIQERTVS VAVDANPWQF
260 270 280 290 300
YRSGVLSKCT KNLNHGVVLV GVQADGAWKI RNSWGSSWGE AGHIRLAGGD
310
TCGICAAPSF PILG
Length:314
Mass (Da):34,935
Last modified:October 23, 2007 - v2
Checksum:i2D580F2BB700AFD0
GO

Sequence cautioni

The sequence CAK89725.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868656 Genomic DNA. Translation: CAK89725.1. Different initiation.
UniGeneiPte.76.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868656 Genomic DNA. Translation: CAK89725.1 . Different initiation.
UniGenei Pte.76.

3D structure databases

ProteinModelPortali A0E358.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

InParanoidi A0E358.

Family and domain databases

InterProi IPR000169. Pept_cys_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2.

Entry informationi

Entry nameiCATL2_PARTE
AccessioniPrimary (citable) accession number: A0E358
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3