A0DTY1 (PP2C4_PARTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable protein phosphatase 2C 4
Short name=PP2C 4
EC=3.1.3.16

Gene names

ORF Names:

GSPATT00020181001

Organism

Paramecium tetraurelia [Reference proteome]

Taxonomic identifier

5888 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Peniculida › Parameciidae › Paramecium

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Enzyme with a broad specificity By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 2 magnesium or manganese ions per subunit By similarity.
Subcellular location	Membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the PP2C family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Probable protein phosphatase 2C 4		PRO_0000307831
Sites
	Metal binding	57	1	Manganese 1 By similarity
	Metal binding	57	1	Manganese 2 By similarity
	Metal binding	58	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	237	1	Manganese 2 By similarity
	Metal binding	289	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0DTY1 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: C63A00AB18150686	FASTA	301	33,666
	10 20 30 40 50 60 MGPYLSQPNK NKTTTSGEGK SIIFAASEMQ GWRNTMEDAH IHVCDLQQDL SIFGVFDGHG 70 80 90 100 110 120 GKEVAQFVEK HFIEELQKNK NFKDQKFEDA LRETFLKMDE LLLTPEGQKE IIQIKGGDDE 130 140 150 160 170 180 ASYAGCTANV ALFHKNVLYV ANAGDSRSVL CRNNTNYDMS VDHKPDNYEE KSRIERAGGF 190 200 210 220 230 240 VSDGRVNGNL NLSRALGDLE YKRDSKLRSN EQLIIALPDI KKVELNQTDK FLLMGCDGVF 250 260 270 280 290 300 ETLDHQDLLK FINQKLGNQQ ITPQLLGRVA EDLLDNLIAP DTSAGTGCDN MTTLIIYLKG K

References

[1]

"Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia." Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M., Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A., Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R. , Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F., Le Mouel A., Lepere G., Malinsky S., Nowacki M., Nowak J.K., Plattner H., Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M., Weissenbach J., Scarpelli C., Schaechter V., Sperling L., Meyer E., Cohen J., Wincker P. Nature 444:171-178(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Stock d4-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT868574 Genomic DNA. Translation: CAK86498.1.
RefSeq	XP_001453895.1. XM_001453858.1.
UniGene	Pte.2272.
3D structure databases
ProteinModelPortal	A0DTY1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5039680.
KEGG	ptm:GSPATT00020181001.
Phylogenomic databases
ProtClustDB	CLSZ2448970.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. IPR000222. PP2C_Mn2_Asp60_BS. IPR015655. Protein_Pase_2C. [Graphical view]
PANTHER	PTHR13832. PTHR13832. 1 hit.
Pfam	PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
PROSITE	PS01032. PP2C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PP2C4_PARTE

Accession

Primary (citable) accession number: A0DTY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	November 28, 2006
Last modified:	March 6, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)