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Protein

Probable protein phosphatase 2C 6

Gene

GSPATT00019634001

Organism
Paramecium tetraurelia
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme with a broad specificity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi57 – 571Manganese 2By similarity
Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi237 – 2371Manganese 2By similarity
Metal bindingi285 – 2851Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 6 (EC:3.1.3.16)
Short name:
PP2C 6
Gene namesi
ORF Names:GSPATT00019634001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600 Componenti: Partially assembled WGS sequence

Subcellular locationi

Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Probable protein phosphatase 2C 6PRO_0000307833Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA0DSB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 294272PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiA0DSB3.
KOiK01090.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0DSB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPYLSQPKT EKTSVTGQNQ VLQYAATHMQ GWRNTMEDAH ISDLNIEPDV
60 70 80 90 100
HLFAVFDGHG GSEVAIFAER HFREELMKNK NYQQKNYEKA LTETFFKIDK
110 120 130 140 150
MLQEPSGLDE LNKIRGVTDE ASLAGCTANV ALIVGKTLYV ANAGDSRSFL
160 170 180 190 200
NRDGKPFDMS KDHKPDDEQE KKRIERAGGF VSDGRVNGNL SLSRALGDLE
210 220 230 240 250
YKKDNRFKPE EQIITALPDV KVTQLSAADK FLLMGCDGVF ETWDHQQILN
260 270 280 290
FINSELKNTQ NLQKAAEKLL DQLLAKDTSL GTGCDNMTCI LIQFK
Length:295
Mass (Da):33,111
Last modified:November 27, 2006 - v1
Checksum:i38665E7161821015
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868552 Genomic DNA. Translation: CAK85930.1.
RefSeqiXP_001453327.1. XM_001453290.1.
UniGeneiPte.3730.

Genome annotation databases

EnsemblProtistsiCAK85930; CAK85930; GSPATT00019634001.
GeneIDi5039112.
KEGGiptm:GSPATT00019634001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868552 Genomic DNA. Translation: CAK85930.1.
RefSeqiXP_001453327.1. XM_001453290.1.
UniGeneiPte.3730.

3D structure databases

ProteinModelPortaliA0DSB3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAK85930; CAK85930; GSPATT00019634001.
GeneIDi5039112.
KEGGiptm:GSPATT00019634001.

Phylogenomic databases

InParanoidiA0DSB3.
KOiK01090.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2.

Entry informationi

Entry nameiPP2C6_PARTE
AccessioniPrimary (citable) accession number: A0DSB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 22, 2007
Last sequence update: November 27, 2006
Last modified: March 31, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.