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Protein

Histone deacetylase

Gene

GSPATT00011565001

Organism
Paramecium tetraurelia
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:GSPATT00011565001Imported
OrganismiParamecium tetraureliaImported
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600: Partially assembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0CYU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

InParanoidiA0CYU7.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A0CYU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQADSDSSR RVAYFYNRLI GKFHYGKEHP MKPKRIAMAH SLIVNFGQLY
60 70 80 90 100
RSLDVYLIRE AQLEELKKFH DPEYVTYLSQ YMSDNKVNFV KEYCSTNNDG
110 120 130 140 150
VIPENLLEEY RLITKWSQNK NTKNLNAEYK VGDSADNPTF SGLFSYCQFS
160 170 180 190 200
AGASIDCAHT ILTGQADIAI NWSGGLHHAK KKEAAGFCYI NDIVLCILEL
210 220 230 240 250
LRIYVRVLYV DIDCHHGDGV EEAFYLTNRV MTLSFHQYGD DFFPGTGQLN
260 270 280 290 300
SVGLGVGRYY AVNVPLKPGI SDGPYLDLFK KVTSRVMETF RPDCVVVQCG
310 320 330 340 350
ADSLSLDRLG ALNLSIKGHG QCITYMKQFG VPLILLGGGG YTIQNVSRCW
360 370 380 390 400
AYETGLCLGQ NIDEPIPTND VYYKNYSGDY HLHFPIQEHV ENKNKAEDLN
410 420 430 440 450
KIVSQVYDHL KNLENAPGIH FHDVPYSFYP NMDLENEDDN KINMDMKQEI
460 470 480
SLSELEQEIG VSDEANAISV NSGSRKIHSK EV
Length:482
Mass (Da):54,559
Last modified:November 28, 2006 - v1
Checksum:i5C27807066825FC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868219 Genomic DNA. Translation: CAK75964.1.
RefSeqiXP_001443361.1. XM_001443324.1.

Genome annotation databases

EnsemblProtistsiCAK75964; CAK75964; GSPATT00011565001.
GeneIDi5029146.
KEGGiptm:GSPATT00011565001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868219 Genomic DNA. Translation: CAK75964.1.
RefSeqiXP_001443361.1. XM_001443324.1.

3D structure databases

ProteinModelPortaliA0CYU7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAK75964; CAK75964; GSPATT00011565001.
GeneIDi5029146.
KEGGiptm:GSPATT00011565001.

Phylogenomic databases

InParanoidiA0CYU7.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2Imported.

Entry informationi

Entry nameiA0CYU7_PARTE
AccessioniPrimary (citable) accession number: A0CYU7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: January 7, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.