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Protein

Histone deacetylase

Gene

GSPATT00011565001

Organism
Paramecium tetraurelia
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136SubstrateUniRule annotation1
Active sitei178Proton acceptorUniRule annotation1
Binding sitei186Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi213Divalent metal cationUniRule annotation1
Metal bindingi215Divalent metal cationUniRule annotation1
Metal bindingi302Divalent metal cationUniRule annotation1
Binding sitei341SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:GSPATT00011565001Imported
OrganismiParamecium tetraureliaImported
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
Proteomesi
  • UP000000600 Componenti: Partially assembled WGS sequence

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi412030.XP_001443361.1

Structurei

3D structure databases

ProteinModelPortaliA0CYU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 354Hist_deacetylInterPro annotationAdd BLAST326

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili396 – 416Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
InParanoidiA0CYU7
KOiK06067
OMAiLWAYETS

Family and domain databases

InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 2 hits
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 2 hits

Sequencei

Sequence statusi: Complete.

A0CYU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQADSDSSR RVAYFYNRLI GKFHYGKEHP MKPKRIAMAH SLIVNFGQLY
60 70 80 90 100
RSLDVYLIRE AQLEELKKFH DPEYVTYLSQ YMSDNKVNFV KEYCSTNNDG
110 120 130 140 150
VIPENLLEEY RLITKWSQNK NTKNLNAEYK VGDSADNPTF SGLFSYCQFS
160 170 180 190 200
AGASIDCAHT ILTGQADIAI NWSGGLHHAK KKEAAGFCYI NDIVLCILEL
210 220 230 240 250
LRIYVRVLYV DIDCHHGDGV EEAFYLTNRV MTLSFHQYGD DFFPGTGQLN
260 270 280 290 300
SVGLGVGRYY AVNVPLKPGI SDGPYLDLFK KVTSRVMETF RPDCVVVQCG
310 320 330 340 350
ADSLSLDRLG ALNLSIKGHG QCITYMKQFG VPLILLGGGG YTIQNVSRCW
360 370 380 390 400
AYETGLCLGQ NIDEPIPTND VYYKNYSGDY HLHFPIQEHV ENKNKAEDLN
410 420 430 440 450
KIVSQVYDHL KNLENAPGIH FHDVPYSFYP NMDLENEDDN KINMDMKQEI
460 470 480
SLSELEQEIG VSDEANAISV NSGSRKIHSK EV
Length:482
Mass (Da):54,559
Last modified:November 28, 2006 - v1
Checksum:i5C27807066825FC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868219 Genomic DNA Translation: CAK75964.1
RefSeqiXP_001443361.1, XM_001443324.1

Genome annotation databases

EnsemblProtistsiCAK75964; CAK75964; GSPATT00011565001
GeneIDi5029146
KEGGiptm:GSPATT00011565001

Similar proteinsi

Entry informationi

Entry nameiA0CYU7_PARTE
AccessioniPrimary (citable) accession number: A0CYU7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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