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Protein

Histone deacetylase

Gene

GSPATT00011565001

Organism
Paramecium tetraurelia
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136SubstrateUniRule annotation1
Active sitei178Proton acceptorUniRule annotation1
Binding sitei186Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi213Divalent metal cationUniRule annotation1
Metal bindingi215Divalent metal cationUniRule annotation1
Metal bindingi302Divalent metal cationUniRule annotation1
Binding sitei341SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:GSPATT00011565001Imported
OrganismiParamecium tetraureliaImported
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
Proteomesi
  • UP000000600 Componenti: Partially assembled WGS sequence

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi412030.XP_001443361.1.

Structurei

3D structure databases

ProteinModelPortaliA0CYU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 354Hist_deacetylInterPro annotationAdd BLAST326

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
InParanoidiA0CYU7.
KOiK06067.
OMAiRMIRGAP.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 2 hits.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A0CYU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQADSDSSR RVAYFYNRLI GKFHYGKEHP MKPKRIAMAH SLIVNFGQLY
60 70 80 90 100
RSLDVYLIRE AQLEELKKFH DPEYVTYLSQ YMSDNKVNFV KEYCSTNNDG
110 120 130 140 150
VIPENLLEEY RLITKWSQNK NTKNLNAEYK VGDSADNPTF SGLFSYCQFS
160 170 180 190 200
AGASIDCAHT ILTGQADIAI NWSGGLHHAK KKEAAGFCYI NDIVLCILEL
210 220 230 240 250
LRIYVRVLYV DIDCHHGDGV EEAFYLTNRV MTLSFHQYGD DFFPGTGQLN
260 270 280 290 300
SVGLGVGRYY AVNVPLKPGI SDGPYLDLFK KVTSRVMETF RPDCVVVQCG
310 320 330 340 350
ADSLSLDRLG ALNLSIKGHG QCITYMKQFG VPLILLGGGG YTIQNVSRCW
360 370 380 390 400
AYETGLCLGQ NIDEPIPTND VYYKNYSGDY HLHFPIQEHV ENKNKAEDLN
410 420 430 440 450
KIVSQVYDHL KNLENAPGIH FHDVPYSFYP NMDLENEDDN KINMDMKQEI
460 470 480
SLSELEQEIG VSDEANAISV NSGSRKIHSK EV
Length:482
Mass (Da):54,559
Last modified:November 28, 2006 - v1
Checksum:i5C27807066825FC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868219 Genomic DNA. Translation: CAK75964.1.
RefSeqiXP_001443361.1. XM_001443324.1.

Genome annotation databases

EnsemblProtistsiCAK75964; CAK75964; GSPATT00011565001.
GeneIDi5029146.
KEGGiptm:GSPATT00011565001.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA0CYU7_PARTE
AccessioniPrimary (citable) accession number: A0CYU7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: July 5, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported