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A0CUB5

- PP2C5_PARTE

UniProt

A0CUB5 - PP2C5_PARTE

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Protein

Probable protein phosphatase 2C 5

Gene

GSPATT00010582001

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Enzyme with a broad specificity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi57 – 571Manganese 2By similarity
Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi237 – 2371Manganese 2By similarity
Metal bindingi285 – 2851Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 5 (EC:3.1.3.16)
Short name:
PP2C 5
Gene namesi
ORF Names:GSPATT00010582001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600: Partially assembled WGS sequence

Subcellular locationi

Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Probable protein phosphatase 2C 5PRO_0000307832Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA0CUB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

InParanoidiA0CUB5.
KOiK17499.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0CUB5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPYLSQPKT EKSTVTGQNQ VFQYAATHMQ GWRNTMEDAH ISDMNIEPDV
60 70 80 90 100
HLFAVFDGHG GSEVAIFAER HFREELMKNK NYQQKNYEKA LTETFFKIDK
110 120 130 140 150
MLQEPSGQDE LNKIRGVNDE TSLAGCTANV ALIVGKTLYV ANAGDSRSFL
160 170 180 190 200
NRDGKPFDMS KDHKPDDDQE KKRIERAGGF VSDGRANGNL SLSRALGDLE
210 220 230 240 250
YKKDSRFKPE EQIISALPDV KVTQLTASDK FLLMGCDGVF ETWDHQQILN
260 270 280 290
FVNQELKSSQ NLQKATEKLL DQLLAKDTSL GTGCDNMTCI LVLFK
Length:295
Mass (Da):33,155
Last modified:November 28, 2006 - v1
Checksum:i53C6D72891A090EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT868185 Genomic DNA. Translation: CAK74382.1.
RefSeqiXP_001441779.1. XM_001441742.1.
UniGeneiPte.257.

Genome annotation databases

EnsemblProtistsiCAK74382; CAK74382; GSPATT00010582001.
GeneIDi5027564.
KEGGiptm:GSPATT00010582001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT868185 Genomic DNA. Translation: CAK74382.1 .
RefSeqi XP_001441779.1. XM_001441742.1.
UniGenei Pte.257.

3D structure databases

ProteinModelPortali A0CUB5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi CAK74382 ; CAK74382 ; GSPATT00010582001 .
GeneIDi 5027564.
KEGGi ptm:GSPATT00010582001.

Phylogenomic databases

InParanoidi A0CUB5.
KOi K17499.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2.

Entry informationi

Entry nameiPP2C5_PARTE
AccessioniPrimary (citable) accession number: A0CUB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3