A0CCD2 (PPX4_PARTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase PP-X homolog 4
EC=3.1.3.16

Gene names

Name:	Ppx4
ORF Names:	GSPATT00037234001

Organism

Paramecium tetraurelia [Reference proteome]

Taxonomic identifier

5888 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Peniculida › Parameciidae › Paramecium

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Sequence similarities	Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Ontologies

Keywords
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Serine/threonine-protein phosphatase PP-X homolog 4		PRO_0000308176
Sites
	Active site	114	1	Proton donor By similarity
	Metal binding	53	1	Iron By similarity
	Metal binding	55	1	Iron By similarity
	Metal binding	81	1	Iron By similarity
	Metal binding	81	1	Manganese By similarity
	Metal binding	113	1	Manganese By similarity
	Metal binding	163	1	Manganese By similarity
	Metal binding	237	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0CCD2 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 3AFA4E91BA512A1E	FASTA	306	34,959
	10 20 30 40 50 60 MSQSDLDRQI AQLRNCENIT EGEVKALCTK AREILVEESN VQRVDAPVTI CGDIHGQFFD 70 80 90 100 110 120 LMELFKVGGD CPDTNYLFLG DFVDRGFNSV ETFLLLLALK VRYPDRITLI RGNHESRQIT 130 140 150 160 170 180 QVYGFYDECL RKYGSLNVWR YCTDIFDYLS LAAVIEEKIF CVHGGLSPSI KTMDDIRAID 190 200 210 220 230 240 RKQEVPHDGA MCDLMWSDPD EIEGWNLSPR GAGYLFGGDV VDDFNRKNNI ELICRAHQLV 250 260 270 280 290 300 MEGYRVMFNE QLVTVWSAPN YCYRCGNVAS ILELDENLAK SYKIFEAAPQ ENRGLPAKKP IPDYFL

References

[1]

"Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia." Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M., Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A., Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R. , Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F., Le Mouel A., Lepere G., Malinsky S., Nowacki M., Nowak J.K., Plattner H., Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M., Weissenbach J., Scarpelli C., Schaechter V., Sperling L., Meyer E., Cohen J., Wincker P. Nature 444:171-178(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Stock d4-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT868060 Genomic DNA. Translation: CAK68449.1.
RefSeq	XP_001435846.1. XM_001435809.1.
UniGene	Pte.3108.
3D structure databases
ProteinModelPortal	A0CCD2.
SMR	A0CCD2. Positions 5-306.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5021631.
KEGG	ptm:GSPATT00037234001.
Phylogenomic databases
KO	K15423.
ProtClustDB	CLSZ2431287.
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPX4_PARTE

Accession

Primary (citable) accession number: A0CCD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	November 28, 2006
Last modified:	February 22, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)