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A0CCD2

- PPX4_PARTE

UniProt

A0CCD2 - PPX4_PARTE

Protein

Serine/threonine-protein phosphatase PP-X homolog 4

Gene

Ppx4

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531Manganese 1By similarity
    Metal bindingi55 – 551Manganese 1By similarity
    Metal bindingi81 – 811Manganese 1By similarity
    Metal bindingi81 – 811Manganese 2By similarity
    Metal bindingi113 – 1131Manganese 2By similarity
    Active sitei114 – 1141Proton donorBy similarity
    Metal bindingi163 – 1631Manganese 2By similarity
    Metal bindingi237 – 2371Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP-X homolog 4 (EC:3.1.3.16)
    Gene namesi
    Name:Ppx4
    ORF Names:GSPATT00037234001
    OrganismiParamecium tetraurelia
    Taxonomic identifieri5888 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
    ProteomesiUP000000600: Partially assembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Serine/threonine-protein phosphatase PP-X homolog 4PRO_0000308176Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA0CCD2.
    SMRiA0CCD2. Positions 5-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK15423.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0CCD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSDLDRQI AQLRNCENIT EGEVKALCTK AREILVEESN VQRVDAPVTI    50
    CGDIHGQFFD LMELFKVGGD CPDTNYLFLG DFVDRGFNSV ETFLLLLALK 100
    VRYPDRITLI RGNHESRQIT QVYGFYDECL RKYGSLNVWR YCTDIFDYLS 150
    LAAVIEEKIF CVHGGLSPSI KTMDDIRAID RKQEVPHDGA MCDLMWSDPD 200
    EIEGWNLSPR GAGYLFGGDV VDDFNRKNNI ELICRAHQLV MEGYRVMFNE 250
    QLVTVWSAPN YCYRCGNVAS ILELDENLAK SYKIFEAAPQ ENRGLPAKKP 300
    IPDYFL 306
    Length:306
    Mass (Da):34,959
    Last modified:November 28, 2006 - v1
    Checksum:i3AFA4E91BA512A1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT868060 Genomic DNA. Translation: CAK68449.1.
    RefSeqiXP_001435846.1. XM_001435809.1.
    UniGeneiPte.3108.

    Genome annotation databases

    EnsemblProtistsiCAK68449; CAK68449; GSPATT00037234001.
    GeneIDi5021631.
    KEGGiptm:GSPATT00037234001.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT868060 Genomic DNA. Translation: CAK68449.1 .
    RefSeqi XP_001435846.1. XM_001435809.1.
    UniGenei Pte.3108.

    3D structure databases

    ProteinModelPortali A0CCD2.
    SMRi A0CCD2. Positions 5-306.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi CAK68449 ; CAK68449 ; GSPATT00037234001 .
    GeneIDi 5021631.
    KEGGi ptm:GSPATT00037234001.

    Phylogenomic databases

    KOi K15423.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Stock d4-2.

    Entry informationi

    Entry nameiPPX4_PARTE
    AccessioniPrimary (citable) accession number: A0CCD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3