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Protein

Serine/threonine-protein phosphatase PP-X homolog 4

Gene

Ppx4

Organism
Paramecium tetraurelia
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Manganese 1By similarity
Metal bindingi55 – 551Manganese 1By similarity
Metal bindingi81 – 811Manganese 1By similarity
Metal bindingi81 – 811Manganese 2By similarity
Metal bindingi113 – 1131Manganese 2By similarity
Active sitei114 – 1141Proton donorBy similarity
Metal bindingi163 – 1631Manganese 2By similarity
Metal bindingi237 – 2371Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-X homolog 4 (EC:3.1.3.16)
Gene namesi
Name:Ppx4
ORF Names:GSPATT00037234001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600 Componenti: Partially assembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Serine/threonine-protein phosphatase PP-X homolog 4PRO_0000308176Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA0CCD2.
SMRiA0CCD2. Positions 5-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiA0CCD2.
KOiK15423.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0CCD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSDLDRQI AQLRNCENIT EGEVKALCTK AREILVEESN VQRVDAPVTI
60 70 80 90 100
CGDIHGQFFD LMELFKVGGD CPDTNYLFLG DFVDRGFNSV ETFLLLLALK
110 120 130 140 150
VRYPDRITLI RGNHESRQIT QVYGFYDECL RKYGSLNVWR YCTDIFDYLS
160 170 180 190 200
LAAVIEEKIF CVHGGLSPSI KTMDDIRAID RKQEVPHDGA MCDLMWSDPD
210 220 230 240 250
EIEGWNLSPR GAGYLFGGDV VDDFNRKNNI ELICRAHQLV MEGYRVMFNE
260 270 280 290 300
QLVTVWSAPN YCYRCGNVAS ILELDENLAK SYKIFEAAPQ ENRGLPAKKP

IPDYFL
Length:306
Mass (Da):34,959
Last modified:November 28, 2006 - v1
Checksum:i3AFA4E91BA512A1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868060 Genomic DNA. Translation: CAK68449.1.
RefSeqiXP_001435846.1. XM_001435809.1.
UniGeneiPte.3108.

Genome annotation databases

EnsemblProtistsiCAK68449; CAK68449; GSPATT00037234001.
GeneIDi5021631.
KEGGiptm:GSPATT00037234001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868060 Genomic DNA. Translation: CAK68449.1.
RefSeqiXP_001435846.1. XM_001435809.1.
UniGeneiPte.3108.

3D structure databases

ProteinModelPortaliA0CCD2.
SMRiA0CCD2. Positions 5-306.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAK68449; CAK68449; GSPATT00037234001.
GeneIDi5021631.
KEGGiptm:GSPATT00037234001.

Phylogenomic databases

InParanoidiA0CCD2.
KOiK15423.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2.

Entry informationi

Entry nameiPPX4_PARTE
AccessioniPrimary (citable) accession number: A0CCD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 28, 2006
Last modified: January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.