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Protein

Probable protein phosphatase 2C 3

Gene

GSPATT00031056001

Organism
Paramecium tetraurelia
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme with a broad specificity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi57 – 571Manganese 2By similarity
Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi237 – 2371Manganese 2By similarity
Metal bindingi289 – 2891Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 3 (EC:3.1.3.16)
Short name:
PP2C 3
Gene namesi
ORF Names:GSPATT00031056001
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600: Partially assembled WGS sequence

Subcellular locationi

Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Probable protein phosphatase 2C 3PRO_0000307830Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA0BQL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

InParanoidiA0BQL0.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0BQL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPYLSQPKR EKVTTSGEGK SVIFAASEMQ GWRNTMEDAH IHRPDIVQDV
60 70 80 90 100
SVFGVFDGHG GREVAQFVEK HFIDELLKNK NFKEQKFEDA LKETFLKMDE
110 120 130 140 150
LLMTPEGAKE LNNYKATDTD ESYAGCTANV ALIHKNTLYV ANAGDSRSVL
160 170 180 190 200
CRNNTNFDMS VDHKPDNNEE KSRIERAGGF VSDGRVNGNL NLSRALGDLE
210 220 230 240 250
YKSDSKLRPN EQLIIAFPDV KKTELTPQDK FILMGCDGVF ETLNHQELLK
260 270 280 290 300
HVNTTLGNSP VTENLLSKAA EDLLDQLLAP DTSQGTGCDN MTTILVYLKK
Length:300
Mass (Da):33,462
Last modified:November 28, 2006 - v1
Checksum:i6143F9FE79355637
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868009 Genomic DNA. Translation: CAK60827.1.
RefSeqiXP_001428225.1. XM_001428188.1.
UniGeneiPte.2558.

Genome annotation databases

EnsemblProtistsiCAK60827; CAK60827; GSPATT00031056001.
GeneIDi5014009.
KEGGiptm:GSPATT00031056001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT868009 Genomic DNA. Translation: CAK60827.1.
RefSeqiXP_001428225.1. XM_001428188.1.
UniGeneiPte.2558.

3D structure databases

ProteinModelPortaliA0BQL0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAK60827; CAK60827; GSPATT00031056001.
GeneIDi5014009.
KEGGiptm:GSPATT00031056001.

Phylogenomic databases

InParanoidiA0BQL0.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2.

Entry informationi

Entry nameiPP2C3_PARTE
AccessioniPrimary (citable) accession number: A0BQL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 28, 2006
Last modified: January 7, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.