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A0BPK2

- A0BPK2_PARTE

UniProt

A0BPK2 - A0BPK2_PARTE

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Protein
Isocitrate dehydrogenase [NADP]
Gene
GSPATT00005218001, GSPATT00009194001
Organism
Paramecium tetraurelia
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901Substrate By similarityUniRule annotation
Binding sitei122 – 1221Substrate By similarityUniRule annotation
Binding sitei145 – 1451Substrate By similarityUniRule annotation
Sitei152 – 1521Critical for catalysis By similarityUniRule annotation
Sitei224 – 2241Critical for catalysis By similarityUniRule annotation
Metal bindingi264 – 2641Magnesium or manganese By similarityUniRule annotation
Metal bindingi287 – 2871Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:GSPATT00005218001Imported, GSPATT00009194001Imported
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600: Partially assembled WGS sequence

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1137Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0BPK2-1 [UniParc]FASTAAdd to Basket

« Hide

MSGPVFKAAA KWTGRKINVK NTVVELDGDE QARIIWKMIR ERLVLPYLNV    50
NLEYYDLSME HRDKTDDKVT FDSGYAILKH KVGVKCATIT ADEARVEEFK 100
LKKMWPSPNG SIRAILDGTV FREPIICKNI PRLVPGWTQP IVIGRHSYGD 150
QYKCQDVKLP GPGKLELIYT PTQGEQVKRT IFEFKGKGGV GLGMYNTYES 200
IVNFAHQSFQ YALMRKYPLM LGTKNTILKQ YDGYFKDIFQ EIFETKYKKD 250
FDANKLWYEH RLIDDLVAQM MKSSGGFVLA LKNYDGDVQS DIVAQGYGSL 300
GMMTSELVAN DGVYESEAAH GTITRHYREH QKGKETSTNS VASIYAWTRG 350
LRHRGRLDNN QELIKFAETI ESSIIQTIES GLFTKDLALI VHGPKADRST 400
YLNTEQFIDA VNGKLQSNLG FLK 423
Length:423
Mass (Da):48,091
Last modified:November 28, 2006 - v1
Checksum:iEA4191BF7E845BF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT868008 Genomic DNA. Translation: CAK60469.1.
CT868130 Genomic DNA. Translation: CAK72802.1.
RefSeqiXP_001427867.1. XM_001427830.1.
XP_001440199.1. XM_001440162.1.
UniGeneiPte.19384.
Pte.59.

Genome annotation databases

EnsemblProtistsiCAK60469; CAK60469; GSPATT00005218001.
CAK72802; CAK72802; GSPATT00009194001.
GeneIDi5013651.
5025984.
KEGGiptm:GSPATT00005218001.
ptm:GSPATT00009194001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT868008 Genomic DNA. Translation: CAK60469.1 .
CT868130 Genomic DNA. Translation: CAK72802.1 .
RefSeqi XP_001427867.1. XM_001427830.1.
XP_001440199.1. XM_001440162.1.
UniGenei Pte.19384.
Pte.59.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi CAK60469 ; CAK60469 ; GSPATT00005218001 .
CAK72802 ; CAK72802 ; GSPATT00009194001 .
GeneIDi 5013651.
5025984.
KEGGi ptm:GSPATT00005218001.
ptm:GSPATT00009194001.

Phylogenomic databases

KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2Imported.
  2. Genoscope
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Stock d4-2Imported.

Entry informationi

Entry nameiA0BPK2_PARTE
AccessioniPrimary (citable) accession number: A0BPK2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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