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A0BPK2

- A0BPK2_PARTE

UniProt

A0BPK2 - A0BPK2_PARTE

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Protein

Isocitrate dehydrogenase [NADP]

Gene

GSPATT00005218001

Organism
Paramecium tetraurelia
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901SubstrateUniRule annotation
Binding sitei122 – 1221SubstrateUniRule annotation
Binding sitei145 – 1451SubstrateUniRule annotation
Sitei152 – 1521Critical for catalysisUniRule annotation
Sitei224 – 2241Critical for catalysis
Metal bindingi264 – 2641Magnesium or manganeseUniRule annotation
Metal bindingi287 – 2871Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:GSPATT00005218001Imported, GSPATT00009194001Imported
OrganismiParamecium tetraureliaImported
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
ProteomesiUP000000600: Partially assembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA0BPK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1137Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

InParanoidiA0BPK2.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0BPK2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGPVFKAAA KWTGRKINVK NTVVELDGDE QARIIWKMIR ERLVLPYLNV
60 70 80 90 100
NLEYYDLSME HRDKTDDKVT FDSGYAILKH KVGVKCATIT ADEARVEEFK
110 120 130 140 150
LKKMWPSPNG SIRAILDGTV FREPIICKNI PRLVPGWTQP IVIGRHSYGD
160 170 180 190 200
QYKCQDVKLP GPGKLELIYT PTQGEQVKRT IFEFKGKGGV GLGMYNTYES
210 220 230 240 250
IVNFAHQSFQ YALMRKYPLM LGTKNTILKQ YDGYFKDIFQ EIFETKYKKD
260 270 280 290 300
FDANKLWYEH RLIDDLVAQM MKSSGGFVLA LKNYDGDVQS DIVAQGYGSL
310 320 330 340 350
GMMTSELVAN DGVYESEAAH GTITRHYREH QKGKETSTNS VASIYAWTRG
360 370 380 390 400
LRHRGRLDNN QELIKFAETI ESSIIQTIES GLFTKDLALI VHGPKADRST
410 420
YLNTEQFIDA VNGKLQSNLG FLK
Length:423
Mass (Da):48,091
Last modified:November 28, 2006 - v1
Checksum:iEA4191BF7E845BF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT868008 Genomic DNA. Translation: CAK60469.1.
CT868130 Genomic DNA. Translation: CAK72802.1.
RefSeqiXP_001427867.1. XM_001427830.1.
XP_001440199.1. XM_001440162.1.
UniGeneiPte.19384.
Pte.59.

Genome annotation databases

EnsemblProtistsiCAK60469; CAK60469; GSPATT00005218001.
CAK72802; CAK72802; GSPATT00009194001.
GeneIDi5013651.
5025984.
KEGGiptm:GSPATT00005218001.
ptm:GSPATT00009194001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT868008 Genomic DNA. Translation: CAK60469.1 .
CT868130 Genomic DNA. Translation: CAK72802.1 .
RefSeqi XP_001427867.1. XM_001427830.1.
XP_001440199.1. XM_001440162.1.
UniGenei Pte.19384.
Pte.59.

3D structure databases

ProteinModelPortali A0BPK2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi CAK60469 ; CAK60469 ; GSPATT00005218001 .
CAK72802 ; CAK72802 ; GSPATT00009194001 .
GeneIDi 5013651.
5025984.
KEGGi ptm:GSPATT00005218001.
ptm:GSPATT00009194001.

Phylogenomic databases

InParanoidi A0BPK2.
KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Stock d4-2Imported.
  2. Genoscope
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Stock d4-2Imported.

Entry informationi

Entry nameiA0BPK2_PARTE
AccessioniPrimary (citable) accession number: A0BPK2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3