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A0BPK2

- A0BPK2_PARTE

UniProt

A0BPK2 - A0BPK2_PARTE

Protein

Isocitrate dehydrogenase [NADP]

Gene

GSPATT00005218001

Organism
Paramecium tetraurelia
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei90 – 901SubstrateUniRule annotation
    Binding sitei122 – 1221SubstrateUniRule annotation
    Binding sitei145 – 1451SubstrateUniRule annotation
    Sitei152 – 1521Critical for catalysisUniRule annotation
    Sitei224 – 2241Critical for catalysisUniRule annotation
    Metal bindingi264 – 2641Magnesium or manganeseUniRule annotation
    Metal bindingi287 – 2871Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:GSPATT00005218001Imported, GSPATT00009194001Imported
    OrganismiParamecium tetraureliaImported
    Taxonomic identifieri5888 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium
    ProteomesiUP000000600: Partially assembled WGS sequence

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni107 – 1137Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0BPK2-1 [UniParc]FASTAAdd to Basket

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    MSGPVFKAAA KWTGRKINVK NTVVELDGDE QARIIWKMIR ERLVLPYLNV    50
    NLEYYDLSME HRDKTDDKVT FDSGYAILKH KVGVKCATIT ADEARVEEFK 100
    LKKMWPSPNG SIRAILDGTV FREPIICKNI PRLVPGWTQP IVIGRHSYGD 150
    QYKCQDVKLP GPGKLELIYT PTQGEQVKRT IFEFKGKGGV GLGMYNTYES 200
    IVNFAHQSFQ YALMRKYPLM LGTKNTILKQ YDGYFKDIFQ EIFETKYKKD 250
    FDANKLWYEH RLIDDLVAQM MKSSGGFVLA LKNYDGDVQS DIVAQGYGSL 300
    GMMTSELVAN DGVYESEAAH GTITRHYREH QKGKETSTNS VASIYAWTRG 350
    LRHRGRLDNN QELIKFAETI ESSIIQTIES GLFTKDLALI VHGPKADRST 400
    YLNTEQFIDA VNGKLQSNLG FLK 423
    Length:423
    Mass (Da):48,091
    Last modified:November 28, 2006 - v1
    Checksum:iEA4191BF7E845BF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT868008 Genomic DNA. Translation: CAK60469.1.
    CT868130 Genomic DNA. Translation: CAK72802.1.
    RefSeqiXP_001427867.1. XM_001427830.1.
    XP_001440199.1. XM_001440162.1.
    UniGeneiPte.19384.
    Pte.59.

    Genome annotation databases

    EnsemblProtistsiCAK60469; CAK60469; GSPATT00005218001.
    CAK72802; CAK72802; GSPATT00009194001.
    GeneIDi5013651.
    5025984.
    KEGGiptm:GSPATT00005218001.
    ptm:GSPATT00009194001.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT868008 Genomic DNA. Translation: CAK60469.1 .
    CT868130 Genomic DNA. Translation: CAK72802.1 .
    RefSeqi XP_001427867.1. XM_001427830.1.
    XP_001440199.1. XM_001440162.1.
    UniGenei Pte.19384.
    Pte.59.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi CAK60469 ; CAK60469 ; GSPATT00005218001 .
    CAK72802 ; CAK72802 ; GSPATT00009194001 .
    GeneIDi 5013651.
    5025984.
    KEGGi ptm:GSPATT00005218001.
    ptm:GSPATT00009194001.

    Phylogenomic databases

    KOi K00031.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Stock d4-2Imported.
    2. Genoscope
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Stock d4-2Imported.

    Entry informationi

    Entry nameiA0BPK2_PARTE
    AccessioniPrimary (citable) accession number: A0BPK2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3