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A0B9U4

- A0B9U4_METTP

UniProt

A0B9U4 - A0B9U4_METTP

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Protein
Probable tRNA pseudouridine synthase B
Gene
truB, Mthe_1702
Organism
Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs By similarity.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Nucleophile By similarityUniRule annotation

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. lyase activity Source: UniProtKB-KW
  3. pseudouridine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation, LyaseImported

Keywords - Biological processi

tRNA processingUniRule annotation

Enzyme and pathway databases

BioCyciMMET349307:GHKI-1753-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
tRNA pseudouridine(55) synthase
tRNA pseudouridylate synthase
tRNA-uridine isomerase
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:Mthe_1702Imported
OrganismiMethanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))Imported
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
ProteomesiUP000000674: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi349307.Mthe_1702.

Structurei

3D structure databases

ProteinModelPortaliA0B9U4.
SMRiA0B9U4. Positions 4-314.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini230 – 30576PUA By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 PUA domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0130.
HOGENOMiHOG000231224.
KOiK11131.
OMAiVDAICHG.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
HAMAPiMF_01081. TruB_arch.
InterProiIPR012960. Dyskerin-like.
IPR002501. PsdUridine_synth.
IPR020103. PsdUridine_synth_cat_dom.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004802. tRNA_PsdUridine_synth_B_fam.
IPR026326. TruB_arch.
IPR004521. Uncharacterised_CHP00451.
[Graphical view]
PANTHERiPTHR23127. PTHR23127. 1 hit.
PfamiPF08068. DKCLD. 1 hit.
PF01472. PUA. 1 hit.
PF01509. TruB_N. 2 hits.
[Graphical view]
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00425. CBF5. 1 hit.
TIGR00451. unchar_dom_2. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0B9U4-1 [UniParc]FASTAAdd to Basket

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MRREGSTNSS YGCFPDRRPL QEHLRLGAIN LDKPSGPTSH EVVAWVKRIL    50
GLEKAGHSGT LDPRVTGILP VLTGDATRVV EFLLTAGKEY VCLMRTHEQV 100
PRKKILEVCE EFSGEIYQRP PLKSSVARNL RTRKIYYIDV LEIEGQRVLM 150
KVGCEAGTYI RKLCYDMGLA LGCGANMEEL RRTKAGPFAE DETLVTLHNL 200
KDAYEIWRES GDESALRRAV LPVERALRHL PGLVISDNAV DAICHGAPLA 250
APGLLSLETD INKGDFVVIY TLKGEAVAIG RAKLSSDEMM VAKSGIVAST 300
ERVIMDPGVY PRRWKHSAEV V 321
Length:321
Mass (Da):35,520
Last modified:November 28, 2006 - v1
Checksum:iD15477BBEAC78DD5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000477 Genomic DNA. Translation: ABK15468.1.
RefSeqiYP_844108.1. NC_008553.1.

Genome annotation databases

EnsemblBacteriaiABK15468; ABK15468; Mthe_1702.
GeneIDi4462662.
KEGGimtp:Mthe_1702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000477 Genomic DNA. Translation: ABK15468.1 .
RefSeqi YP_844108.1. NC_008553.1.

3D structure databases

ProteinModelPortali A0B9U4.
SMRi A0B9U4. Positions 4-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349307.Mthe_1702.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK15468 ; ABK15468 ; Mthe_1702 .
GeneIDi 4462662.
KEGGi mtp:Mthe_1702.

Phylogenomic databases

eggNOGi COG0130.
HOGENOMi HOG000231224.
KOi K11131.
OMAi VDAICHG.

Enzyme and pathway databases

BioCyci MMET349307:GHKI-1753-MONOMER.

Family and domain databases

Gene3Di 2.30.130.10. 1 hit.
HAMAPi MF_01081. TruB_arch.
InterProi IPR012960. Dyskerin-like.
IPR002501. PsdUridine_synth.
IPR020103. PsdUridine_synth_cat_dom.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004802. tRNA_PsdUridine_synth_B_fam.
IPR026326. TruB_arch.
IPR004521. Uncharacterised_CHP00451.
[Graphical view ]
PANTHERi PTHR23127. PTHR23127. 1 hit.
Pfami PF08068. DKCLD. 1 hit.
PF01472. PUA. 1 hit.
PF01509. TruB_N. 2 hits.
[Graphical view ]
SMARTi SM00359. PUA. 1 hit.
[Graphical view ]
SUPFAMi SSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsi TIGR00425. CBF5. 1 hit.
TIGR00451. unchar_dom_2. 1 hit.
PROSITEi PS50890. PUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6194 / PT.

Entry informationi

Entry nameiA0B9U4_METTP
AccessioniPrimary (citable) accession number: A0B9U4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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