Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A0B9U4 (A0B9U4_METTP) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Probable tRNA pseudouridine synthase B HAMAP-Rule MF_01081

EC=5.4.99.25 HAMAP-Rule MF_01081
Alternative name(s):
tRNA pseudouridine(55) synthase HAMAP-Rule MF_01081
tRNA pseudouridylate synthase HAMAP-Rule MF_01081
tRNA-uridine isomerase HAMAP-Rule MF_01081
Gene names
Name:truB HAMAP-Rule MF_01081
Ordered Locus Names:Mthe_1702 EMBL ABK15468.1
OrganismMethanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP] EMBL ABK15468.1
Taxonomic identifier349307 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs By similarity. HAMAP-Rule MF_01081

Catalytic activity

tRNA uridine55 = tRNA pseudouridine55. HAMAP-Rule MF_01081

Sequence similarities

Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. HAMAP-Rule MF_01081

Contains 1 PUA domain. HAMAP-Rule MF_01081

Ontologies

Keywords
   Biological processtRNA processing HAMAP-Rule MF_01081
   Molecular functionIsomerase HAMAP-Rule MF_01081
Lyase EMBL ABK15468.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA pseudouridine synthesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

lyase activity

Inferred from electronic annotation. Source: UniProtKB-KW

pseudouridine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain230 – 30576PUA By similarity HAMAP-Rule MF_01081

Sites

Active site621Nucleophile By similarity HAMAP-Rule MF_01081

Sequences

Sequence LengthMass (Da)Tools
A0B9U4 [UniParc].

Last modified November 28, 2006. Version 1.
Checksum: D15477BBEAC78DD5

FASTA32135,520
        10         20         30         40         50         60 
MRREGSTNSS YGCFPDRRPL QEHLRLGAIN LDKPSGPTSH EVVAWVKRIL GLEKAGHSGT 

        70         80         90        100        110        120 
LDPRVTGILP VLTGDATRVV EFLLTAGKEY VCLMRTHEQV PRKKILEVCE EFSGEIYQRP 

       130        140        150        160        170        180 
PLKSSVARNL RTRKIYYIDV LEIEGQRVLM KVGCEAGTYI RKLCYDMGLA LGCGANMEEL 

       190        200        210        220        230        240 
RRTKAGPFAE DETLVTLHNL KDAYEIWRES GDESALRRAV LPVERALRHL PGLVISDNAV 

       250        260        270        280        290        300 
DAICHGAPLA APGLLSLETD INKGDFVVIY TLKGEAVAIG RAKLSSDEMM VAKSGIVAST 

       310        320 
ERVIMDPGVY PRRWKHSAEV V 

« Hide

References

[1]"Complete sequence of Methanosaeta thermophila PT."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Smith K.S., Ingram-Smith C., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 6194 / PT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000477 Genomic DNA. Translation: ABK15468.1.
RefSeqYP_844108.1. NC_008553.1.

3D structure databases

ProteinModelPortalA0B9U4.
SMRA0B9U4. Positions 4-314.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING349307.Mthe_1702.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK15468; ABK15468; Mthe_1702.
GeneID4462662.
KEGGmtp:Mthe_1702.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0130.
HOGENOMHOG000231224.
KOK11131.
OMAVDAICHG.

Enzyme and pathway databases

BioCycMMET349307:GHKI-1753-MONOMER.

Family and domain databases

Gene3D2.30.130.10. 1 hit.
HAMAPMF_01081. TruB_arch.
InterProIPR012960. Dyskerin-like.
IPR002501. PsdUridine_synth.
IPR020103. PsdUridine_synth_cat_dom.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004802. tRNA_PsdUridine_synth_B_fam.
IPR026326. TruB_arch.
IPR004521. Uncharacterised_CHP00451.
[Graphical view]
PANTHERPTHR23127. PTHR23127. 1 hit.
PfamPF08068. DKCLD. 1 hit.
PF01472. PUA. 1 hit.
PF01509. TruB_N. 2 hits.
[Graphical view]
SMARTSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsTIGR00425. CBF5. 1 hit.
TIGR00451. unchar_dom_2. 1 hit.
PROSITEPS50890. PUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0B9U4_METTP
AccessionPrimary (citable) accession number: A0B9U4
Entry history
Integrated into UniProtKB/TrEMBL: November 28, 2006
Last sequence update: November 28, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)