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A0B9U4

- A0B9U4_METTP

UniProt

A0B9U4 - A0B9U4_METTP

Protein

Probable tRNA pseudouridine synthase B

Gene

truB

Organism
Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

    Catalytic activityi

    tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei62 – 621NucleophileUniRule annotation

    GO - Molecular functioni

    1. lyase activity Source: UniProtKB-KW
    2. pseudouridine synthase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: InterPro

    GO - Biological processi

    1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotation, LyaseImported

    Keywords - Biological processi

    tRNA processingUniRule annotation

    Enzyme and pathway databases

    BioCyciMMET349307:GHKI-1753-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
    Alternative name(s):
    tRNA pseudouridine(55) synthaseUniRule annotation
    tRNA pseudouridylate synthaseUniRule annotation
    tRNA-uridine isomeraseUniRule annotation
    Gene namesi
    Name:truBUniRule annotation
    Ordered Locus Names:Mthe_1702Imported
    OrganismiMethanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))Imported
    Taxonomic identifieri349307 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
    ProteomesiUP000000674: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi349307.Mthe_1702.

    Structurei

    3D structure databases

    ProteinModelPortaliA0B9U4.
    SMRiA0B9U4. Positions 4-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini230 – 30576PUAUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.UniRule annotation
    Contains 1 PUA domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0130.
    HOGENOMiHOG000231224.
    KOiK11131.
    OMAiVDAICHG.

    Family and domain databases

    Gene3Di2.30.130.10. 1 hit.
    HAMAPiMF_01081. TruB_arch.
    InterProiIPR012960. Dyskerin-like.
    IPR002501. PsdUridine_synth.
    IPR020103. PsdUridine_synth_cat_dom.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    IPR004802. tRNA_PsdUridine_synth_B_fam.
    IPR026326. TruB_arch.
    IPR004521. Uncharacterised_CHP00451.
    [Graphical view]
    PANTHERiPTHR23127. PTHR23127. 1 hit.
    PfamiPF08068. DKCLD. 1 hit.
    PF01472. PUA. 1 hit.
    PF01509. TruB_N. 2 hits.
    [Graphical view]
    SMARTiSM00359. PUA. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsiTIGR00425. CBF5. 1 hit.
    TIGR00451. unchar_dom_2. 1 hit.
    PROSITEiPS50890. PUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0B9U4-1 [UniParc]FASTAAdd to Basket

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    MRREGSTNSS YGCFPDRRPL QEHLRLGAIN LDKPSGPTSH EVVAWVKRIL    50
    GLEKAGHSGT LDPRVTGILP VLTGDATRVV EFLLTAGKEY VCLMRTHEQV 100
    PRKKILEVCE EFSGEIYQRP PLKSSVARNL RTRKIYYIDV LEIEGQRVLM 150
    KVGCEAGTYI RKLCYDMGLA LGCGANMEEL RRTKAGPFAE DETLVTLHNL 200
    KDAYEIWRES GDESALRRAV LPVERALRHL PGLVISDNAV DAICHGAPLA 250
    APGLLSLETD INKGDFVVIY TLKGEAVAIG RAKLSSDEMM VAKSGIVAST 300
    ERVIMDPGVY PRRWKHSAEV V 321
    Length:321
    Mass (Da):35,520
    Last modified:November 28, 2006 - v1
    Checksum:iD15477BBEAC78DD5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000477 Genomic DNA. Translation: ABK15468.1.
    RefSeqiYP_844108.1. NC_008553.1.

    Genome annotation databases

    EnsemblBacteriaiABK15468; ABK15468; Mthe_1702.
    GeneIDi4462662.
    KEGGimtp:Mthe_1702.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000477 Genomic DNA. Translation: ABK15468.1 .
    RefSeqi YP_844108.1. NC_008553.1.

    3D structure databases

    ProteinModelPortali A0B9U4.
    SMRi A0B9U4. Positions 4-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349307.Mthe_1702.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK15468 ; ABK15468 ; Mthe_1702 .
    GeneIDi 4462662.
    KEGGi mtp:Mthe_1702.

    Phylogenomic databases

    eggNOGi COG0130.
    HOGENOMi HOG000231224.
    KOi K11131.
    OMAi VDAICHG.

    Enzyme and pathway databases

    BioCyci MMET349307:GHKI-1753-MONOMER.

    Family and domain databases

    Gene3Di 2.30.130.10. 1 hit.
    HAMAPi MF_01081. TruB_arch.
    InterProi IPR012960. Dyskerin-like.
    IPR002501. PsdUridine_synth.
    IPR020103. PsdUridine_synth_cat_dom.
    IPR002478. PUA.
    IPR015947. PUA-like_domain.
    IPR004802. tRNA_PsdUridine_synth_B_fam.
    IPR026326. TruB_arch.
    IPR004521. Uncharacterised_CHP00451.
    [Graphical view ]
    PANTHERi PTHR23127. PTHR23127. 1 hit.
    Pfami PF08068. DKCLD. 1 hit.
    PF01472. PUA. 1 hit.
    PF01509. TruB_N. 2 hits.
    [Graphical view ]
    SMARTi SM00359. PUA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsi TIGR00425. CBF5. 1 hit.
    TIGR00451. unchar_dom_2. 1 hit.
    PROSITEi PS50890. PUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6194 / PTImported.

    Entry informationi

    Entry nameiA0B9U4_METTP
    AccessioniPrimary (citable) accession number: A0B9U4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3