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Protein

Probable L-tyrosine/L-aspartate decarboxylase

Gene

mfnA

Organism
Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.UniRule annotation

Catalytic activityi

L-tyrosine = tyramine + CO2.UniRule annotation
L-aspartate = beta-alanine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: methanofuran biosynthesis

This protein is involved in the pathway methanofuran biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway methanofuran biosynthesis and in Cofactor biosynthesis.

Pathwayi: coenzyme A biosynthesis

This protein is involved in the pathway coenzyme A biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00080.
UPA00241.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-tyrosine/L-aspartate decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation, EC:4.1.1.25UniRule annotation)
Short name:
TDC/ADCUniRule annotation
Gene namesi
Name:mfnAUniRule annotation
Ordered Locus Names:Mthe_1636
OrganismiMethanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanothrix
Proteomesi
  • UP000000674 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931861 – 383Probable L-tyrosine/L-aspartate decarboxylaseAdd BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei227N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi349307.Mthe_1636.

Structurei

3D structure databases

ProteinModelPortaliA0B9M9.
SMRiA0B9M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family. MfnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00027. Archaea.
COG0076. LUCA.
HOGENOMiHOG000246269.
KOiK18933.
OMAiDPHKMGL.
OrthoDBiPOG093Z06IK.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01610. MfnA_decarbox. 1 hit.
InterProiView protein in InterPro
IPR020931. MfnA.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015422. PyrdxlP-dep_Trfase_dom1.
IPR015421. PyrdxlP-dep_Trfase_major.
IPR021115. Pyridoxal-P_BS.
PfamiView protein in Pfam
PF00282. Pyridoxal_deC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.
PROSITEiView protein in PROSITE
PS00392. DDC_GAD_HDC_YDC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0B9M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTFPEKGLS EDMVTDLLKE MRSRDCPYDR LLSTMCTRPH PVAVRAYSMF
60 70 80 90 100
LETNLGDPGL FPGTAEIERR VVGILGSLLG CSDATGYVST GGTESNIQAV
110 120 130 140 150
RAARNSSGRR DGNIVVPRSA HFSFDKIADL LNLEVRKAEL DESLRVDVGD
160 170 180 190 200
VERLIDDRTV CLVGIAGTTE FGQVDPIGDL SELAIENGIP LHVDAAFGGF
210 220 230 240 250
VLPFLEKDCM WDFRAEGVQS ITIDPHKMGM SPIPAGGLIF RSSDPLRRLE
260 270 280 290 300
TETYYLTVSR QASLTGTRSG AAAAATYAVI MHLGIDGYRK VVRRCMDMTE
310 320 330 340 350
HLVSEARAMG IEPVIEPVMN VVALRVDDPP GVRRALLERG WHVSMTREPK
360 370 380
ALRLILMPHM TDENLDLFLS DLEDVLISLR RGG
Length:383
Mass (Da):42,137
Last modified:July 10, 2007 - v2
Checksum:i933D420351A9CB1C
GO

Sequence cautioni

The sequence ABK15403 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA. Translation: ABK15403.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABK15403; ABK15403; Mthe_1636.
KEGGimtp:Mthe_1636.

Similar proteinsi

Entry informationi

Entry nameiMFNA_METTP
AccessioniPrimary (citable) accession number: A0B9M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome