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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. no protein annotated in this organism
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:Mthe_1540
OrganismiMethanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanothrix
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000186091 – 208N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST208

Proteomic databases

PRIDEiA0B9D8

Interactioni

Protein-protein interaction databases

STRINGi349307.Mthe_1540

Structurei

3D structure databases

ProteinModelPortaliA0B9D8
SMRiA0B9D8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01983 Archaea
COG0135 LUCA
HOGENOMiHOG000161598
KOiK01817
OMAiFYAKSPR
OrthoDBiPOG093Z0IDC

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

A0B9D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRVKICGLM DEYELECALK AGADALGFVV EIERSRHRLS LDEARNLIGM
60 70 80 90 100
VPPFTTSVAV VEPAGVDDAV RLADYLQSDA LQIHGDLSPE EIEEIKRRVP
110 120 130 140 150
QRIIVAVPPG SDRAVEVSRI ADAVLVDTPV SGGLGGSGRT HDWSVTARMR
160 170 180 190 200
STLHAPLILA GGLRPENVMD AINVVKPYAV DVSSGVETNG RKDPVKAEEF

VRRVRSCQ
Length:208
Mass (Da):22,520
Last modified:November 28, 2006 - v1
Checksum:i6213A208F2E44B7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA Translation: ABK15312.1

Genome annotation databases

EnsemblBacteriaiABK15312; ABK15312; Mthe_1540
KEGGimtp:Mthe_1540

Entry informationi

Entry nameiTRPF_METTP
AccessioniPrimary (citable) accession number: A0B9D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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