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A0B966

- SYE_METTP

UniProt

A0B966 - SYE_METTP

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMET349307:GHKI-1509-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:Mthe_1466
    OrganismiMethanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
    Taxonomic identifieri349307 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
    ProteomesiUP000000674: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 564564Glutamate--tRNA ligasePRO_0000331010Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349307.Mthe_1466.

    Structurei

    3D structure databases

    ProteinModelPortaliA0B966.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi107 – 11711"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiYLGWDDP.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0B966-1 [UniParc]FASTAAdd to Basket

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    MTEEIRELIE KFALQNAVKY RSAPNHGAVM GKLMGERPDL RPRAREIAPL    50
    ITSVLNEIER MSPEQWESRL REMAPELIEE ISARKEPAKG LQPLEGAEGG 100
    VVMRFAPNPN GPPTLGSARG IIINSEYVKM YGGKFILRFD DTDPVNKRPM 150
    IEAYDWYIED CKWLGAEPHE IVAASQRVEK YYEVAEELIR RGGAYVCLCE 200
    QTAFKALKDA AMPCPHRDQT VDENMALWNK MLDGSFQEGE AVLRVKTDIK 250
    HKDPAMRDWA GFRIVTKSHP LVGERYRVWP LLDFESAVED HLLGVTHILR 300
    GKDLIDSERR QRYLYDHMGW VYPRVLHWGR VKIFQFGAFS TSKLRKAIEA 350
    GEYSGWDDPR LPTVRAMRRR GITAEALRKF MIDLGVGETD ISISMDSIYA 400
    ENRRIVDPIA NRRFFVWDPV EIEIKGEVPE VAEAPLHPTI DRGTRRIRAG 450
    GRLLLCKEDV AGLAPGSRIR LKDLCNIEIK EIFPLRAELI DLSPETAKRL 500
    KLRIIHWAPV EGIPVRVLGP DKTDTGIGEH GISDELDRIV QFERYGFVRI 550
    DSVGEEVVAY FAHR 564
    Length:564
    Mass (Da):64,383
    Last modified:November 28, 2006 - v1
    Checksum:i1D3BE679CE0D901F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000477 Genomic DNA. Translation: ABK15240.1.
    RefSeqiWP_011696632.1. NC_008553.1.
    YP_843880.1. NC_008553.1.

    Genome annotation databases

    EnsemblBacteriaiABK15240; ABK15240; Mthe_1466.
    GeneIDi4461921.
    KEGGimtp:Mthe_1466.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000477 Genomic DNA. Translation: ABK15240.1 .
    RefSeqi WP_011696632.1. NC_008553.1.
    YP_843880.1. NC_008553.1.

    3D structure databases

    ProteinModelPortali A0B966.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349307.Mthe_1466.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK15240 ; ABK15240 ; Mthe_1466 .
    GeneIDi 4461921.
    KEGGi mtp:Mthe_1466.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi YLGWDDP.

    Enzyme and pathway databases

    BioCyci MMET349307:GHKI-1509-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6194 / PT.

    Entry informationi

    Entry nameiSYE_METTP
    AccessioniPrimary (citable) accession number: A0B966
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3