A0B8Z5 (A0B8Z5_METTP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897
Ordered Locus Names:	Mthe_1394

Organism

Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP]

Taxonomic identifier

349307 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosaetaceae › Methanosaeta

Protein attributes

Sequence length	796 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_01897
Ligand	ATP-binding HAMAP MF_01897 DNA-binding HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0B8Z5 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: 6F37F610F23E6F5E	FASTA	796	88,476
	10 20 30 40 50 60 MAEIDVDVTE EMKSSYIDYA MSVIVGRALP DVRDGLKPVH RRILYAMYEQ GVTFDQPYKK 70 80 90 100 110 120 SARIVGDVMG KYHPHGDVAI YDTMVRMAQD FSMRYTLIDG QGNFGSVDGD PPAAMRYTEV 130 140 150 160 170 180 RLSKIAGEML ADIEKDTVDF VPNYDGSLKE PTVLPSRLPN LLVNGSTGIA VGMATNIPPH 190 200 210 220 230 240 NLREVVYALI HLIENPDASV TDLMNFIRGP DFPTGGYIVG RSGIESAYST GRGTITIRAR 250 260 270 280 290 300 SEIEEGRRGS RIIFTELPYQ VNKAKVVEDI AELVKAGRVD GISEIRDESD REGIRLVVEL 310 320 330 340 350 360 KQGVNPQVVL NQLHKHTQLE TTYGIINLVL VDGQPRTLTL KETLEQYINY RAEVIERRTR 370 380 390 400 410 420 FELEQAEKRA HILAGILIAL RDIDEVIALI RGSPSPSDAR NLLMNRFGLS EEQARAILDM 430 440 450 460 470 480 RLQRLTGLEQ EKVASEAREL ESTIARLKGI LASRTEVLDI IKNELRELDE IYGDDRRTEI 490 500 510 520 530 540 LESVESVRPE DLIQDEEVAV IITNNGYIKR QPLSVYRMQR RGGKGSIGAE TKSEDFVTDI 550 560 570 580 590 600 FTASTLDYLM IFTDRGKAHW LRVYEIPMVS KVARGRPIAS LLQLEENERI TEAIPVESFG 610 620 630 640 650 660 TDEYIVLATR NGSIVKTPLR AFSNPRRGGI KAVNLRGDSL VAARLTDGSR ELIVATKKGK 670 680 690 700 710 720 AIRFHESDVR SSGRGSMGVK AINLSEGDEL ISMDVVKEGE TLFTITTQGY GKRTELSEYP 730 740 750 760 770 780 LQRRGGKGVK NIDTRRGDVV AAITVSDDDG LLITTKEGVM IRIAASDVRV QGRATQGVKI 790 MDVKPGDEIS DVARVD

References

[1]

"Complete sequence of Methanosaeta thermophila PT." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Smith K.S., Ingram-Smith C., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6194 / PT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000477 Genomic DNA. Translation: ABK15169.1.
RefSeq	YP_843809.1. NC_008553.1.
3D structure databases
ProteinModelPortal	A0B8Z5.
SMR	A0B8Z5. Positions 25-480.
ModBase	Search...
Protein-protein interaction databases
STRING	A0B8Z5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4462060.
GenomeReviews	Gene locus Mthe_1394 in contig CP000477_GR.
KEGG	mtp:Mthe_1394.
NMPDR	fig|349307.7.peg.1451.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05278.
HOGENOM	HBG635183.
OMA	TGRGRIY.
PhylomeDB	A0B8Z5.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0B8Z5_METTP

Accession

Primary (citable) accession number: A0B8Z5

Entry history

Integrated into UniProtKB/TrEMBL:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)