A0B8K7 (A0B8K7_METTP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741 RuleBase RU004370
EC=6.3.3.1 HAMAP MF_00741 RuleBase RU004370

Alternative name(s):
AIR synthase HAMAP MF_00741
AIRS HAMAP MF_00741
Phosphoribosyl-aminoimidazole synthetase HAMAP MF_00741

Gene names

Name:	purM HAMAP MF_00741
Ordered Locus Names:	Mthe_1252

Organism

Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT)) [Complete proteome] [HAMAP]

Taxonomic identifier

349307 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosaetaceae › Methanosaeta

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741 RuleBase RU004370
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. RuleBase RU004371 HAMAP MF_00741
Subcellular location	Cytoplasm By similarity HAMAP MF_00741.
Sequence similarities	Belongs to the AIR synthase family. HAMAP MF_00741 RuleBase RU004370

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00741
Cellular component	Cytoplasm HAMAP MF_00741
Ligand	ATP-binding HAMAP MF_00741 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00741 RuleBase RU004370 EMBL ABK15031.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0B8K7 [UniParc]. Last modified November 28, 2006. Version 1. Checksum: CC304C70ED97868B	FASTA	332	35,849
	10 20 30 40 50 60 MKGMTYSDAG VDIELENRSI DAMRRRLTFS RKGFGAPLTG IGHYAGLIDM GEFAIAMTTD 70 80 90 100 110 120 GVGSKILIAN AMRKWDTIGI DCIAMNVNDL LAIGAEPLAF VDYLAVERVD PEVSEQIAVG 130 140 150 160 170 180 LQKGAEISNI SIVGGETASL PEMIRGLDLA GTAIGYVKKE KVITGEKVRI GDAVVGVPST 190 200 210 220 230 240 GLHSNGYTLA RRIIESSGYT YFDKMPGDSR SIGEILLTPT RIYIEVLELL QRCDVHGLAH 250 260 270 280 290 300 ITGSGLLKLH RITDLGFEIT DPIEPHPVFK FLQELGGVDD VEMYRTFNMG MGFVVVLPEE 310 320 330 QADDACRIMG PGSKVIGRIV ESGLRTGGIR LC

References

[1]

"Complete sequence of Methanosaeta thermophila PT." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Smith K.S., Ingram-Smith C., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 6194 / PT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000477 Genomic DNA. Translation: ABK15031.1.
RefSeq	YP_843671.1. NC_008553.1.
3D structure databases
ProteinModelPortal	A0B8K7.
ModBase	Search...
Protein-protein interaction databases
STRING	A0B8K7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4462538.
GenomeReviews	Gene locus Mthe_1252 in contig CP000477_GR.
KEGG	mtp:Mthe_1252.
NMPDR	fig|349307.7.peg.1298.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04189.
HOGENOM	HBG531222.
OMA	GIDMIAM.
ProtClustDB	PRK05385.
Family and domain databases
HAMAP	MF_00741_A. AIRS_A. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0B8K7_METTP

Accession

Primary (citable) accession number: A0B8K7

Entry history

Integrated into UniProtKB/TrEMBL:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)