ID   DP2L_METTP              Reviewed;        1109 AA.
AC   A0B8K5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   05-MAY-2009, entry version 14.
DE   RecName: Full=DNA polymerase II large subunit;
DE            Short=Pol II;
DE            EC=2.7.7.7;
GN   Name=polC; OrderedLocusNames=Mthe_1250;
OS   Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix
OS   thermophila (strain DSM 6194 / PT)).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosaetaceae; Methanosaeta.
OX   NCBI_TaxID=349307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Smith K.S., Ingram-Smith C.,
RA   Richardson P.;
RT   "Complete sequence of Methanosaeta thermophila PT.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possesses two activities: a DNA synthesis (polymerase)
CC       and an exonucleolytic activity that degrades single stranded DNA
CC       in the 3'- to 5'-direction. Has a template-primer preference which
CC       is characteristic of a replicative DNA polymerase (By similarity).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts
CC       progressively in a 3'- to 5'-direction, releasing nucleoside 5'-
CC       phosphates.
CC   -!- SUBUNIT: Heterodimer of a large subunit and a small subunit (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the archaeal DNA polymerase II family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000477; ABK15029.1; -; Genomic_DNA.
DR   RefSeq; YP_843669.1; -.
DR   GeneID; 4463181; -.
DR   GenomeReviews; CP000477_GR; Mthe_1250.
DR   KEGG; mtp:Mthe_1250; -.
DR   NMPDR; fig|349307.7.peg.1296; -.
DR   OMA; A0B8K5; NCDGDED.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:HAMAP.
DR   GO; GO:0003677; F:DNA binding; IEA:HAMAP.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:HAMAP.
DR   GO; GO:0000738; P:DNA catabolic process, exonucleolytic; IEA:HAMAP.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IEA:HAMAP.
DR   HAMAP; MF_00324; -; 1.
DR   InterPro; IPR004475; PolC_DP2.
DR   InterPro; IPR016033; PolC_DP2_N.
DR   Pfam; PF03833; PolC_DP2; 1.
DR   PIRSF; PIRSF016275; PolC_DP2; 1.
DR   TIGRFAMs; TIGR00354; polC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA replication; DNA-binding;
KW   DNA-directed DNA polymerase; Exonuclease; Hydrolase;
KW   Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Transferase.
FT   CHAIN         1   1109       DNA polymerase II large subunit.
FT                                /FTId=PRO_0000294691.
SQ   SEQUENCE   1109 AA;  122895 MW;  9CAFADACAC8D75C2 CRC64;
     MSAEYFERLE RGLREEMEIA RRARSKGLDP ETDVEIPIAV DLAERVEKLV SIPGVAERIR
     EFEVQGLSRE EAALAIGRDF AEGRLGKGAS RLDAIDMAIR TSVALLTEGV VAAPIEGIAR
     VGLGKNDDGS EYLKVYYAGP IRSAGGTAQA LSVLVADYVR RSMGIAPYKP TDEEIERYVE
     EIGLYKRLQH LQYTPSDDEI RTIIRNCPVC IDGEPTEEEE VSGYRDLPRV ETNRVRGGIA
     LVSAEGIALK RPKIKKHVSK LGIDGWGWLD VLGGEKKDGG GSSGKFLRDL IAGRPVFSHP
     SRPGGFRLRY GRSRNTGLAA AGINPATMMV LNQFLAPGTQ IKVEQPGKAA AVAPVSSIEG
     PTVRLTNGDV VRIDDPSSFP WISSPEALRR NISKIIDLGE ILVSFGDFME NNRPLAPASY
     TFEWWAEEFR RAGGDPAGME HVDGRTAIRL SRDFGVPLHP DHTYLWHDIT LDELDLLADA
     ASDGEIDGDA LLMDMREDVK EVLEKLLVHH KVRDGMIVVE DALPLLLCLG VDETGRRWRR
     EDLNADNALS AVNQLSGLVI RARAPTRIGC RMGRPEKSDR REMRPPPHVL FPTGSEGGKS
     RLVNEAAEHG FIEVVVERRR CPSCGKEGFA FRCECGAHTE RVRACLSCGV RADDKCPRCG
     TETSAATRMR IDVKGTLARA LESLGERVDN IRGVMGLTSR DSTPEPLEKG VLRAKHGVFI
     FKDGTSRYDL TDLPLTHFRP REIGTSVDAL LDLGYTHDIH GKPLESDDQI LELKVQDVVL
     CRNAGDWLLR VSKFIDDLLV KFYGLEPYYN AERPEDLIGR LMIGLAPHTS AGVLCRLIGF
     TRASAGYAHP YFHAAKRRNC DGDEDCVMLL MDALLNFSRS YLPEKRGGKM DAPLVLTTRI
     NPAEVDKEAH NLDLSFIYPL EFYEATLRNA NPKDVEGLID LVSKRLGSEG QYCGFGFTHD
     TDDIAGGPRN SSYKTLETMI DKMKSQLELA KLIRAVDATD VAERVINSHF LPDLMGNLRA
     FSRQSVRCVK CNAKYRRPPL SESCPKCGGR LVLTVHEGSV RKYLEVSMKV AEEYGVSSYT
     RQRLELIQME IESLFRSDKV KQTGLADFV
//