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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Methanosaeta thermophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanothrix thermophila)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMMET349307:GHKI-1287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:Mthe_1250
OrganismiMethanosaeta thermophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanothrix thermophila)
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
Proteomesi
  • UP000000674 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11091109DNA polymerase II large subunitPRO_0000294691Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi349307.Mthe_1250.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0B8K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEYFERLE RGLREEMEIA RRARSKGLDP ETDVEIPIAV DLAERVEKLV
60 70 80 90 100
SIPGVAERIR EFEVQGLSRE EAALAIGRDF AEGRLGKGAS RLDAIDMAIR
110 120 130 140 150
TSVALLTEGV VAAPIEGIAR VGLGKNDDGS EYLKVYYAGP IRSAGGTAQA
160 170 180 190 200
LSVLVADYVR RSMGIAPYKP TDEEIERYVE EIGLYKRLQH LQYTPSDDEI
210 220 230 240 250
RTIIRNCPVC IDGEPTEEEE VSGYRDLPRV ETNRVRGGIA LVSAEGIALK
260 270 280 290 300
RPKIKKHVSK LGIDGWGWLD VLGGEKKDGG GSSGKFLRDL IAGRPVFSHP
310 320 330 340 350
SRPGGFRLRY GRSRNTGLAA AGINPATMMV LNQFLAPGTQ IKVEQPGKAA
360 370 380 390 400
AVAPVSSIEG PTVRLTNGDV VRIDDPSSFP WISSPEALRR NISKIIDLGE
410 420 430 440 450
ILVSFGDFME NNRPLAPASY TFEWWAEEFR RAGGDPAGME HVDGRTAIRL
460 470 480 490 500
SRDFGVPLHP DHTYLWHDIT LDELDLLADA ASDGEIDGDA LLMDMREDVK
510 520 530 540 550
EVLEKLLVHH KVRDGMIVVE DALPLLLCLG VDETGRRWRR EDLNADNALS
560 570 580 590 600
AVNQLSGLVI RARAPTRIGC RMGRPEKSDR REMRPPPHVL FPTGSEGGKS
610 620 630 640 650
RLVNEAAEHG FIEVVVERRR CPSCGKEGFA FRCECGAHTE RVRACLSCGV
660 670 680 690 700
RADDKCPRCG TETSAATRMR IDVKGTLARA LESLGERVDN IRGVMGLTSR
710 720 730 740 750
DSTPEPLEKG VLRAKHGVFI FKDGTSRYDL TDLPLTHFRP REIGTSVDAL
760 770 780 790 800
LDLGYTHDIH GKPLESDDQI LELKVQDVVL CRNAGDWLLR VSKFIDDLLV
810 820 830 840 850
KFYGLEPYYN AERPEDLIGR LMIGLAPHTS AGVLCRLIGF TRASAGYAHP
860 870 880 890 900
YFHAAKRRNC DGDEDCVMLL MDALLNFSRS YLPEKRGGKM DAPLVLTTRI
910 920 930 940 950
NPAEVDKEAH NLDLSFIYPL EFYEATLRNA NPKDVEGLID LVSKRLGSEG
960 970 980 990 1000
QYCGFGFTHD TDDIAGGPRN SSYKTLETMI DKMKSQLELA KLIRAVDATD
1010 1020 1030 1040 1050
VAERVINSHF LPDLMGNLRA FSRQSVRCVK CNAKYRRPPL SESCPKCGGR
1060 1070 1080 1090 1100
LVLTVHEGSV RKYLEVSMKV AEEYGVSSYT RQRLELIQME IESLFRSDKV

KQTGLADFV
Length:1,109
Mass (Da):122,895
Last modified:November 28, 2006 - v1
Checksum:i9CAFADACAC8D75C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA. Translation: ABK15029.1.

Genome annotation databases

EnsemblBacteriaiABK15029; ABK15029; Mthe_1250.
KEGGimtp:Mthe_1250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA. Translation: ABK15029.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349307.Mthe_1250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK15029; ABK15029; Mthe_1250.
KEGGimtp:Mthe_1250.

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Enzyme and pathway databases

BioCyciMMET349307:GHKI-1287-MONOMER.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 6194 / JCM 14653 / NBRC 101360 / PT.

Entry informationi

Entry nameiDP2L_METTP
AccessioniPrimary (citable) accession number: A0B8K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 28, 2006
Last modified: November 11, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.