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Protein

Digeranylgeranylglyceryl phosphate synthase

Gene

Mthe_1142

Organism
Methanosaeta thermophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanothrix thermophila)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMTHE349307:G12X8-1151-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Digeranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.42UniRule annotation)
Short name:
DGGGP synthaseUniRule annotation
Short name:
DGGGPSUniRule annotation
Alternative name(s):
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Geranylgeranylglycerol-phosphate geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Mthe_1142
OrganismiMethanosaeta thermophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanothrix thermophila)
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
Proteomesi
  • UP000000674 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalUniRule annotationAdd BLAST21
Transmembranei33 – 53HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei104 – 121HelicalUniRule annotationAdd BLAST18
Transmembranei139 – 159HelicalUniRule annotationAdd BLAST21
Transmembranei198 – 218HelicalUniRule annotationAdd BLAST21
Transmembranei247 – 267HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_50001487481 – 267Digeranylgeranylglyceryl phosphate synthaseAdd BLAST267

Interactioni

Protein-protein interaction databases

STRINGi349307.Mthe_1142.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
HOGENOMiHOG000152645.
KOiK17105.
OMAiKYGMFLA.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth. 1 hit.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0B8A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLLEIMRPA NCVMAGAASL TGMLVSGALL QSLHTPVLVF SAVLLITGGG
60 70 80 90 100
NAINDYFDRE IDAVNRPDRP IPSGRISPRA ALIWSVALFI AGCLIAGLIN
110 120 130 140 150
QSCLALALLN SFVLIIYAAR LKGLPVAGNI AISYLTGTTF LFGGLAASPS
160 170 180 190 200
SITAFLSILS ALATLSREIV KDIEDLPGDL AHGAKTLPAF IGKRKSFVLA
210 220 230 240 250
SLVLIVAMLL SYLVPLGIDY QAAVSIANLA FLLSIKRMLC GDASGSQRWI
260
KMGMGMALVA FLIGYHI
Length:267
Mass (Da):28,046
Last modified:November 28, 2006 - v1
Checksum:iC36F8B57758A8B6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA. Translation: ABK14924.1.

Genome annotation databases

EnsemblBacteriaiABK14924; ABK14924; Mthe_1142.
KEGGimtp:Mthe_1142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA. Translation: ABK14924.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349307.Mthe_1142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK14924; ABK14924; Mthe_1142.
KEGGimtp:Mthe_1142.

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
HOGENOMiHOG000152645.
KOiK17105.
OMAiKYGMFLA.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciMTHE349307:G12X8-1151-MONOMER.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth. 1 hit.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDGGGP_METTP
AccessioniPrimary (citable) accession number: A0B8A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: November 28, 2006
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.