ID   DNLI_METTP              Reviewed;         552 AA.
AC   A0B7F9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=DNA ligase;
DE            EC=6.5.1.1;
DE   AltName: Full=Polydeoxyribonucleotide synthase [ATP];
GN   Name=lig; OrderedLocusNames=Mthe_0844;
OS   Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix
OS   thermophila (strain DSM 6194 / PT)).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosaetaceae; Methanosaeta.
OX   NCBI_TaxID=349307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Smith K.S., Ingram-Smith C.,
RA   Richardson P.;
RT   "Complete sequence of Methanosaeta thermophila PT.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA ligase that seals nicks in double-stranded DNA
CC       during DNA replication, DNA recombination and DNA repair (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) +
CC       (deoxyribonucleotide)(m) = AMP + diphosphate +
CC       (deoxyribonucleotide)(n+m).
CC   -!- COFACTOR: Divalent metal cations (By similarity).
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
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DR   EMBL; CP000477; ABK14633.1; -; Genomic_DNA.
DR   RefSeq; YP_843273.1; -.
DR   GeneID; 4463057; -.
DR   GenomeReviews; CP000477_GR; Mthe_0844.
DR   KEGG; mtp:Mthe_0844; -.
DR   NMPDR; fig|349307.7.peg.872; -.
DR   OMA; A0B7F9; SNLHLGA.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:HAMAP.
DR   GO; GO:0006281; P:DNA repair; IEA:HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:HAMAP.
DR   HAMAP; MF_00407; -; 1.
DR   InterPro; IPR000977; DNA_ligase.
DR   InterPro; IPR012309; DNA_ligase_A_C.
DR   InterPro; IPR012310; DNA_ligase_A_M.
DR   InterPro; IPR012308; DNA_ligase_A_N.
DR   InterPro; IPR016059; DNA_ligase_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage;
KW   DNA recombination; DNA repair; DNA replication; Ligase; Metal-binding;
KW   Nucleotide-binding.
FT   CHAIN         1    552       DNA ligase.
FT                                /FTId=PRO_1000049873.
FT   ACT_SITE    246    246       N6-AMP-lysine intermediate (By
FT                                similarity).
FT   BINDING     244    244       ATP (By similarity).
FT   BINDING     251    251       ATP (By similarity).
FT   BINDING     266    266       ATP (By similarity).
FT   BINDING     296    296       ATP (By similarity).
FT   BINDING     336    336       ATP (By similarity).
FT   BINDING     408    408       ATP (By similarity).
FT   BINDING     414    414       ATP (By similarity).
SQ   SEQUENCE   552 AA;  61188 MW;  4A0865A5F8711501 CRC64;
     MTGFARFAEL CERISQTSGS LEKTDILASF LSDLESDDLR IVAGFVMGVV IPGTELGVGP
     SLLYESISRA TGLSSDAVNE LLRATGDPGL VAYRAVERRK PLTLAAFSGS EGLEVQDVYQ
     RFLSIAKASG RGSQEIRVKN LQYMFSEASP LEAKYIARLA MEDMRIGVGE GLVRDAIAKA
     FGVSKEDVER AYNLTNDLGL VAEYAKLGRL NELGISINRP IKMMLAQIGE SIEASLAEGA
     TAVEWKFDGA RVQIHKDKGN VRIFSRRLED VTSSLPEIRE IVRGHVRART AILDGEAVAT
     GEDGRPLPFQ EILRRFRRKY GVARTAKTIP LKLHLFDIIY MDGASLLDEP LEERRRVLVS
     VADPEIIAEQ VVTSDVHRVE EIYREALAAG HEGVMLKNPS STYTPGKRGK NWLKIKPLLE
     SLDLVVIGAR WGEGKRANLL GSYRLACIDT DTGELKDVGW VATGITDEML AELTELFREL
     IVKENGMEVE VHPEIVFEVG YEEIQRSPNY SSGYALRFPR LIAVRDDKSP SEADTLERIG
     EIYRLQRGRS KK
//