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Protein

DNA ligase

Gene

lig

Organism
Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244ATPUniRule annotation1
Active sitei246N6-AMP-lysine intermediateUniRule annotation1
Binding sitei251ATPUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei296ATPUniRule annotation1
Binding sitei336ATPUniRule annotation1
Binding sitei408ATPUniRule annotation1
Binding sitei414ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mthe_0844
OrganismiMethanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanothrix
Proteomesi
  • UP000000674 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000498731 – 552DNA ligaseAdd BLAST552

Interactioni

Protein-protein interaction databases

STRINGi349307.Mthe_0844

Structurei

3D structure databases

ProteinModelPortaliA0B7F9
SMRiA0B7F9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A0B7F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGFARFAEL CERISQTSGS LEKTDILASF LSDLESDDLR IVAGFVMGVV
60 70 80 90 100
IPGTELGVGP SLLYESISRA TGLSSDAVNE LLRATGDPGL VAYRAVERRK
110 120 130 140 150
PLTLAAFSGS EGLEVQDVYQ RFLSIAKASG RGSQEIRVKN LQYMFSEASP
160 170 180 190 200
LEAKYIARLA MEDMRIGVGE GLVRDAIAKA FGVSKEDVER AYNLTNDLGL
210 220 230 240 250
VAEYAKLGRL NELGISINRP IKMMLAQIGE SIEASLAEGA TAVEWKFDGA
260 270 280 290 300
RVQIHKDKGN VRIFSRRLED VTSSLPEIRE IVRGHVRART AILDGEAVAT
310 320 330 340 350
GEDGRPLPFQ EILRRFRRKY GVARTAKTIP LKLHLFDIIY MDGASLLDEP
360 370 380 390 400
LEERRRVLVS VADPEIIAEQ VVTSDVHRVE EIYREALAAG HEGVMLKNPS
410 420 430 440 450
STYTPGKRGK NWLKIKPLLE SLDLVVIGAR WGEGKRANLL GSYRLACIDT
460 470 480 490 500
DTGELKDVGW VATGITDEML AELTELFREL IVKENGMEVE VHPEIVFEVG
510 520 530 540 550
YEEIQRSPNY SSGYALRFPR LIAVRDDKSP SEADTLERIG EIYRLQRGRS

KK
Length:552
Mass (Da):61,188
Last modified:November 28, 2006 - v1
Checksum:i4A0865A5F8711501
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA Translation: ABK14633.1

Genome annotation databases

EnsemblBacteriaiABK14633; ABK14633; Mthe_0844
KEGGimtp:Mthe_0844

Similar proteinsi

Entry informationi

Entry nameiDNLI_METTP
AccessioniPrimary (citable) accession number: A0B7F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 28, 2006
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health