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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei632ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mthe_0802
OrganismiMethanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanothrix
Proteomesi
  • UP000000674 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003348471 – 950Leucine--tRNA ligaseAdd BLAST950

Proteomic databases

PRIDEiA0B7B7

Interactioni

Protein-protein interaction databases

STRINGi349307.Mthe_0802

Structurei

3D structure databases

ProteinModelPortaliA0B7B7
SMRiA0B7B7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi629 – 633"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0B7B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNEYSAHE IEAKWQRIWE EEGVFHAEPD SRKKFFLTIP YPYLNGNLHA
60 70 80 90 100
GHTRTFTIGD AIARYHRMLG ENVLFPMAFH ATGTPIVGLS ELIANRDPLI
110 120 130 140 150
WDVYTRLHGI PEEELEKLTT PEAIVDYFRK QAKLAMRSIG YSIDWRREFT
160 170 180 190 200
TTDPAYNRFI EWQFGILREK GYVTKGSHPV RWCPNDQNPV EDHDILRGED
210 220 230 240 250
ATILDFTLIK FRLDDKVLPC ATLRPETVFG VTNLWVNPNV VHYIARVNDE
260 270 280 290 300
VWIVSPQAYH KLTFTDRSVK KIGEIPGEEL IGKKARNPVT GDEIIILPAT
310 320 330 340 350
FVDPDSGSGI VMSVPAHAPL DYLALRDLYD ADLSKYGITE DLRKIKFISL
360 370 380 390 400
ISVPEYGEFP AVDAVNELGV KDQNDPKAEE ATKLVYRREF HNGVLKEITG
410 420 430 440 450
RYAGTPVHRI KDILLQDLIN QGVAEIFYEF SETPVICRCG ARCVVKMVRD
460 470 480 490 500
QWFLEYSDPV WKSRVLECLA GMQIIPEEMR AEFINKIDWL KDKACARRKG
510 520 530 540 550
LGTRLPWDRE WLIESLADST IYMAFYILAK YVNAGMKIDR LVPQFFDYIF
560 570 580 590 600
LGKGTPEEVS SLTGVDVDTV RRIREDFEYW YPVDLRTSGK DLVANHLLFF
610 620 630 640 650
LYHHVAIFPE SLWPRAIAVN GFVSLEGQKM SKSRGPILTL KQAVAENGAD
660 670 680 690 700
VTRLYILANA EYTQDADWRN DGAQATRGQV ERFYTLAREI IERNDIDESA
710 720 730 740 750
ELTLIDRWML SRLQRRIIET TDALNNIQTR RALQSAFYHM LNDLRWYERR
760 770 780 790 800
GGRNQLRRIL NVWVRLMAPF TPHICEEIWQ NIGEGYVSRA PWPVPDASLI
810 820 830 840 850
DEQAERAEAY LEQTQKDIEE IIRVTKTKPR RIVLYTTPVW KREMLRLALE
860 870 880 890 900
VSKGGRLDMG ALMKSAMGHP EIQSHKKDAP KYGGKLAKSV HALSGDVLAL
910 920 930 940 950
DELGILSRER EYLSQAFGCP VEVYSADNPP YDPKGRAQNA EPGRPAIYIE
Length:950
Mass (Da):109,145
Last modified:November 28, 2006 - v1
Checksum:iDFCBC447C11687B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA Translation: ABK14591.1

Genome annotation databases

EnsemblBacteriaiABK14591; ABK14591; Mthe_0802
KEGGimtp:Mthe_0802

Similar proteinsi

Entry informationi

Entry nameiSYL_METTP
AccessioniPrimary (citable) accession number: A0B7B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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