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A0B7B7

- SYL_METTP

UniProt

A0B7B7 - SYL_METTP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei632 – 6321ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMET349307:GHKI-828-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Mthe_0802
    OrganismiMethanosaeta thermophila (strain DSM 6194 / PT) (Methanothrix thermophila (strain DSM 6194 / PT))
    Taxonomic identifieri349307 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanosaeta
    ProteomesiUP000000674: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 950950Leucine--tRNA ligasePRO_0000334847Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349307.Mthe_0802.

    Structurei

    3D structure databases

    ProteinModelPortaliA0B7B7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi629 – 6335"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiHAPFDYL.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0B7B7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRNEYSAHE IEAKWQRIWE EEGVFHAEPD SRKKFFLTIP YPYLNGNLHA    50
    GHTRTFTIGD AIARYHRMLG ENVLFPMAFH ATGTPIVGLS ELIANRDPLI 100
    WDVYTRLHGI PEEELEKLTT PEAIVDYFRK QAKLAMRSIG YSIDWRREFT 150
    TTDPAYNRFI EWQFGILREK GYVTKGSHPV RWCPNDQNPV EDHDILRGED 200
    ATILDFTLIK FRLDDKVLPC ATLRPETVFG VTNLWVNPNV VHYIARVNDE 250
    VWIVSPQAYH KLTFTDRSVK KIGEIPGEEL IGKKARNPVT GDEIIILPAT 300
    FVDPDSGSGI VMSVPAHAPL DYLALRDLYD ADLSKYGITE DLRKIKFISL 350
    ISVPEYGEFP AVDAVNELGV KDQNDPKAEE ATKLVYRREF HNGVLKEITG 400
    RYAGTPVHRI KDILLQDLIN QGVAEIFYEF SETPVICRCG ARCVVKMVRD 450
    QWFLEYSDPV WKSRVLECLA GMQIIPEEMR AEFINKIDWL KDKACARRKG 500
    LGTRLPWDRE WLIESLADST IYMAFYILAK YVNAGMKIDR LVPQFFDYIF 550
    LGKGTPEEVS SLTGVDVDTV RRIREDFEYW YPVDLRTSGK DLVANHLLFF 600
    LYHHVAIFPE SLWPRAIAVN GFVSLEGQKM SKSRGPILTL KQAVAENGAD 650
    VTRLYILANA EYTQDADWRN DGAQATRGQV ERFYTLAREI IERNDIDESA 700
    ELTLIDRWML SRLQRRIIET TDALNNIQTR RALQSAFYHM LNDLRWYERR 750
    GGRNQLRRIL NVWVRLMAPF TPHICEEIWQ NIGEGYVSRA PWPVPDASLI 800
    DEQAERAEAY LEQTQKDIEE IIRVTKTKPR RIVLYTTPVW KREMLRLALE 850
    VSKGGRLDMG ALMKSAMGHP EIQSHKKDAP KYGGKLAKSV HALSGDVLAL 900
    DELGILSRER EYLSQAFGCP VEVYSADNPP YDPKGRAQNA EPGRPAIYIE 950
    Length:950
    Mass (Da):109,145
    Last modified:November 28, 2006 - v1
    Checksum:iDFCBC447C11687B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000477 Genomic DNA. Translation: ABK14591.1.
    RefSeqiWP_011695987.1. NC_008553.1.
    YP_843231.1. NC_008553.1.

    Genome annotation databases

    EnsemblBacteriaiABK14591; ABK14591; Mthe_0802.
    GeneIDi4461989.
    KEGGimtp:Mthe_0802.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000477 Genomic DNA. Translation: ABK14591.1 .
    RefSeqi WP_011695987.1. NC_008553.1.
    YP_843231.1. NC_008553.1.

    3D structure databases

    ProteinModelPortali A0B7B7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349307.Mthe_0802.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK14591 ; ABK14591 ; Mthe_0802 .
    GeneIDi 4461989.
    KEGGi mtp:Mthe_0802.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi HAPFDYL.

    Enzyme and pathway databases

    BioCyci MMET349307:GHKI-828-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 6194 / PT.

    Entry informationi

    Entry nameiSYL_METTP
    AccessioniPrimary (citable) accession number: A0B7B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3