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Protein

FAD synthase

Gene

ribL

Organism
Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.UniRule annotation

Catalytic activityi

ATP + FMN = diphosphate + FAD.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: FAD biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FAD from FMN.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. FAD synthase (ribL)
This subpathway is part of the pathway FAD biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FAD from FMN, the pathway FAD biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 14ATPUniRule annotation2
Nucleotide bindingi18 – 21ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00277; UER00407

Names & Taxonomyi

Protein namesi
Recommended name:
FAD synthaseUniRule annotation (EC:2.7.7.2UniRule annotation)
Alternative name(s):
FMN adenylyltransferaseUniRule annotation
Flavin adenine dinucleotide synthaseUniRule annotation
Gene namesi
Name:ribLUniRule annotation
Ordered Locus Names:Mthe_0791
OrganismiMethanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) (Methanosaeta thermophila)
Taxonomic identifieri349307 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosaetaceaeMethanothrix
Proteomesi
  • UP000000674 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004062671 – 143FAD synthaseAdd BLAST143

Proteomic databases

PRIDEiA0B7A6

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi349307.Mthe_0791

Structurei

3D structure databases

ProteinModelPortaliA0B7A6
SMRiA0B7A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal FAD synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01222 Archaea
COG0615 LUCA
HOGENOMiHOG000284153
KOiK14656
OMAiVAHDETV
OrthoDBiPOG093Z0AQ4

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_02115 FAD_synth_arch, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR024902 FAD_synth_RibL
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit

Sequencei

Sequence statusi: Complete.

A0B7A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGTMTRVMA TGTFDILHPG HLLYLERSRA LGDELVVVVA RDINVKHKPR
60 70 80 90 100
PVVPEDQRLR MVSALKMVDM AVLGSVTDIF EPVRALRPDI ITLGYDQYMD
110 120 130 140
ENWLEGELRK RGLMARVVRI SEREPCELCS SRQIVEKILK ERC
Length:143
Mass (Da):16,445
Last modified:November 28, 2006 - v1
Checksum:i44F36AC2609002D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000477 Genomic DNA Translation: ABK14580.1

Genome annotation databases

EnsemblBacteriaiABK14580; ABK14580; Mthe_0791
KEGGimtp:Mthe_0791

Similar proteinsi

Entry informationi

Entry nameiRIBL_METTP
AccessioniPrimary (citable) accession number: A0B7A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: November 28, 2006
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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